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  • MDPI AG  (18)
  • Liu, Yan  (18)
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  • MDPI AG  (18)
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  • 1
    Online Resource
    Online Resource
    Proteomics Research on the Protective Effect of Mangiferin on H9C2 Cell Injury Induced by H2O2
    MDPI AG ; 2019
    In:  Molecules Vol. 24, No. 10 ( 2019-05-17), p. 1911-
    Details
    In: Molecules, MDPI AG, Vol. 24, No. 10 ( 2019-05-17), p. 1911-
    Abstract: Cardiovascular disease is one of the leading causes of morbidity and mortality worldwide. Mangiferin is a natural glucosylxanthone with antioxidant and anti-inflammatory properties, which has been confirmed to protect cardiac cells from myocardial infarction and myocardial ischemia reperfusion injury (MIRI); however, the underlying mechanism is still unclear. As oxidative stress is a major pathogenesis of MIRI, an H9C2 cell injury induced by hydrogen peroxide (H2O2) was established to simulate MIRI in vitro. Herein, the protective effect of mangiferin against MIRI was evaluated and the isobaric tags for relative and absolute quantitation (iTRAQ)-based proteomics was applied to explore the underlying molecular mechanism. In this research, mangiferin markedly ameliorated the oxidative imbalance by increasing the antioxidative capacity of the H9C2 cell. Moreover, proteomics analysis revealed that mangiferin pretreatment brought twenty differently-expressed proteins back to normal, most of which were related to glucose and fatty acid metabolism. Glycolysis, citrate cycle, and fatty acid degradation pathways were highlighted by Kyoto Encyclopedia of Gene and Genomes (KEGG) analysis. Western blot validation of six cardiac metabolism-related proteins were consistent with the proteomics analysis. Taken together, mangiferin protected the cardiomyocytes from MIRI by enhancing the antioxidant capacity and increasing the activities of glycolysis, citrate cycle, and fatty acid degradation pathways.
    Type of Medium: Online Resource
    ISSN: 1420-3049
    URL: Article
    DOI: 10.3390/molecules24101911
    Language: English
    Publisher: MDPI AG
    Publication Date: 2019
    detail.hit.zdb_id: 2008644-1
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  • 2
    Online Resource
    Online Resource
    Numerical Investigation of Turbine Blades with Leading-Edge Tubercles in Uniform Current
    MDPI AG ; 2021
    In:  Water Vol. 13, No. 16 ( 2021-08-13), p. 2205-
    Details
    In: Water, MDPI AG, Vol. 13, No. 16 ( 2021-08-13), p. 2205-
    Abstract: Inspired by the tubercles on humpback whale flippers, leading-edge tubercles have been incorporated into the design of wings and turbine blades in an attempt to improve their hydrodynamic performance. Although promising improvements, especially in terms of the stall performance, have been demonstrated in the limited research that exists to date, the effectiveness of the leading-edge tubercles seems to be influenced by the base blade. This paper focuses on the introduction of sinusoidal leading-edge tubercles to a base blade developed from the classic NACA0018 airfoil, and numerically investigates the effectiveness of leading-edge tubercles on the hydrodynamics associated with the blade in uniform current with different attack angles. Both the macroscopic parameters, such as the lift and drag forces, and the micro-scale flow characteristics, including the vortex and flow separation, are analyzed. The results indicate that the leading-edge tubercles brings a significant influence on the hydrodynamic forces acting on the blade when subjected to an attack angle greater than 15°. This study also reveals the important role of the turbulence and flow separation on hydrodynamic loading on the blade and the considerable influence of the tubercles on such micro-scale flow characteristics. Although the conditions applied in this work are relatively ideal (e.g., the blade is fixed in a uniform flow and the end effect is ignored), the satisfactory agreement between the numerical and corresponding experimental data implies that the results are acceptable. This work builds a good reference for our future work on the hydrodynamic performance of tidal turbines which adopt this kind of blade for operating in both uniform and shearing currents.
    Type of Medium: Online Resource
    ISSN: 2073-4441
    URL: Article
    DOI: 10.3390/w13162205
    Language: English
    Publisher: MDPI AG
    Publication Date: 2021
    detail.hit.zdb_id: 2521238-2
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  • 3
    Online Resource
    Online Resource
    New Glycosides from the Fruits of Nicandra physaloides
    MDPI AG ; 2017
    In:  Molecules Vol. 22, No. 5 ( 2017-05-17), p. 828-
    Details
    In: Molecules, MDPI AG, Vol. 22, No. 5 ( 2017-05-17), p. 828-
    Abstract: Three new glycosides (1–3) and 15 known ones (4–18) were isolated and identified from the fruits of Nicandra physaloides. The structures of these compounds were established by 1D and 2D NMR spectra and HR-ESI-MS. The compounds (4–18) were the first time isolated from the Nicandra genus and they (except 8, 10, 14) exhibited inhibitions on the NO release of LPS-induced RAW 264.7 cells with IC50 values from 26.9 to 47.5 μM.
    Type of Medium: Online Resource
    ISSN: 1420-3049
    URL: Article
    DOI: 10.3390/molecules22050828
    Language: English
    Publisher: MDPI AG
    Publication Date: 2017
    detail.hit.zdb_id: 2008644-1
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  • 4
    Online Resource
    Online Resource
    Assessing and Prioritising Delay Factors of Prefabricated Concrete Building Projects in China
    MDPI AG ; 2018
    In:  Applied Sciences Vol. 8, No. 11 ( 2018-11-21), p. 2324-
    Details
    In: Applied Sciences, MDPI AG, Vol. 8, No. 11 ( 2018-11-21), p. 2324-
    Abstract: Prefabricated construction has been widely accepted as an alternative to conventional cast-in-situ construction, given its improved performance. However, prefabricated concrete building projects frequently encounter significant delays. It is, therefore, crucial to identify key factors affecting schedule and explore strategies to minimise the schedule delays for prefabricated concrete building projects. This paper adopts the decision-making trial and evaluation laboratory (DEMATEL) model and analytic network process (ANP) method to quantify the cause-and-effect relationships and prioritise the key delay factors in terms of their importance in the Chinese construction industry. The DEMATEL model evaluates the extent to which each factor impacts other factors. The quantified extents are then converted into a prioritisation matrix through ANP. The delay factors of prefabricated construction projects are selected and categorised based on a literature review and an expert interview. Questionnaires are then implemented to collect the data. The results reveal that the issue of inefficient structural connections for prefabricated components is found to be the most significant factor and most easily affected by other delay factors. This research also suggests prioritising major delay factors, such as ‘lack of communication among participants’ and ‘low productivity’, in the Chinese construction industry during scheduling control. Overall, this research contributes an assessment framework for decision making in the scheduling management of prefabricated construction.
    Type of Medium: Online Resource
    ISSN: 2076-3417
    URL: Article
    DOI: 10.3390/app8112324
    Language: English
    Publisher: MDPI AG
    Publication Date: 2018
    detail.hit.zdb_id: 2704225-X
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  • 5
    Online Resource
    Online Resource
    Job Burnout and Occupational Stressors among Chinese Healthcare Professionals at County-Level Health Alliances
    MDPI AG ; 2020
    In:  International Journal of Environmental Research and Public Health Vol. 17, No. 6 ( 2020-03-12), p. 1848-
    Details
    In: International Journal of Environmental Research and Public Health, MDPI AG, Vol. 17, No. 6 ( 2020-03-12), p. 1848-
    Abstract: Background: This study aimed to examine the degrees of job burnout and occupational stressors and their associations among healthcare professionals from county-level health alliances in Qinghai–Tibet Plateau, China. Methods: A cross-sectional study was conducted in county-level health alliances in Qinghai Province, China, in November 2018. The Maslach Burnout Inventory—General Survey and the 38-item Chinese version of the “Scale for occupational stressors on clinicians” were used. Medical staff in four health alliances from two counties were invited to complete the questionnaire. Results: A total of 1052 (age: 34.06 ± 9.22 years, 79.1% females) healthcare professionals were included, 68.2% (95% CI: 65.2–71.0%) of the participants had job burnout symptoms. Occupational stressors had positive associations with moderate (OR = 1.06, 95% CI: 1.05–1.07) and serious (OR = 1.15, 95% CI: 1.13–1.19) level of job burnout. Stressors from vocational interest produced the greatest magnitude of odds ratio (OR = 1.76, 95% CI: 1.62–1.92) for serious degree of burnout, followed by doctor–patient relationship, interpersonal relationship as well as other domains of occupational stressors. Conclusions: Job burnout was very common among healthcare professionals working in Chinese county-level health alliances, different occupational stressors had associations with job burnout. Appropriate and effective policies and measures should be developed and implemented.
    Type of Medium: Online Resource
    ISSN: 1660-4601
    URL: Article
    DOI: 10.3390/ijerph17061848
    Language: English
    Publisher: MDPI AG
    Publication Date: 2020
    detail.hit.zdb_id: 2175195-X
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  • 6
    Online Resource
    Online Resource
    Prenatal Cases Reflect the Complexity of the COL1A1/2 Associated Osteogenesis Imperfecta
    MDPI AG ; 2022
    In:  Genes Vol. 13, No. 9 ( 2022-09-02), p. 1578-
    Details
    In: Genes, MDPI AG, Vol. 13, No. 9 ( 2022-09-02), p. 1578-
    Abstract: Introduction: Osteogenesis imperfecta (OI) is a rare mendelian skeletal dysplasia with autosomal dominant or recessive inheritance pattern, and almost the most common primary osteoporosis in prenatal settings. The diversity of clinical presentation and genetic etiology in prenatal OI cases presents a challenge to counseling yet has seldom been discussed in previous studies. Methods: Ten cases with suspected fetal OI were enrolled and submitted to a genetic detection using conventional karyotyping, chromosomal microarray analysis (CMA), and whole-exome sequencing (WES). Sanger sequencing was used as the validation method for potential diagnostic variants. In silico analysis of specific missense variants was also performed. Results: The karyotyping and CMA results of these cases were normal, while WES identified OI-associated variants in the COL1A1/2 genes in all ten cases. Six of these variants were novel. Additionally, four cases here exhibited distinctive clinical and/or genetic characteristics, including the situations of intrafamilial phenotypic variability, parental mosaicism, and “dual nosogenesis” (mutations in collagen I and another gene). Conclusion: Our study not only expands the spectrum of COL1A1/2-related OI, but also highlights the complexity that occurs in prenatal OI and the importance of clarifying its pathogenic mechanisms.
    Type of Medium: Online Resource
    ISSN: 2073-4425
    URL: Article
    DOI: 10.3390/genes13091578
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2527218-4
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  • 7
    Online Resource
    Online Resource
    Integrated Omic Analysis of Human Plasma Metabolites and Microbiota in a Hypertension Cohort
    MDPI AG ; 2023
    In:  Nutrients Vol. 15, No. 9 ( 2023-04-25), p. 2074-
    Details
    In: Nutrients, MDPI AG, Vol. 15, No. 9 ( 2023-04-25), p. 2074-
    Abstract: Hypertension is closely related to metabolic dysregulation, which is associated with microbial dysbiosis and altered host–microbiota interactions. However, plasma metabolite profiles and their relationships to oral/gut microbiota in hypertension have not been evaluated in depth. Plasma, saliva, subgingival plaques, and feces were collected from 52 hypertensive participants and 24 healthy controls in a cross-sectional cohort. Untargeted metabolomic profiling of plasma was performed using high-performance liquid chromatography–mass spectrometry. Microbial profiling of oral and gut samples was determined via 16S rRNA and metagenomic sequencing. Correlations between metabolites and clinic parameters/microbiota were identified using Spearman’s correlation analysis. Metabolomic evaluation showed distinct clusters of metabolites in plasma between hypertensive participants and control participants. Hypertensive participants had six significantly increased and thirty-seven significantly decreased plasma metabolites compared to controls. The plasma metabolic similarity significantly correlated with the community similarity of microbiota. Both oral and gut microbial community composition had significant correlations with metabolites such as Sphingosine 1-phosphate, a molecule involved in the regulation of blood pressure. Plasma metabolites had a larger number of significant correlations with bacterial genera than fungal genera. The shared oral/gut bacterial genera had more correlations with metabolites than unique genera but shared fungal genera and metabolites did not show clear clusters. The hypertension group had fewer correlations between plasma metabolites and bacteria/fungi than controls at species level. The integrative analysis of plasma metabolome and oral/gut microbiome identified unreported alterations of plasma metabolites in hypertension and revealed correlations between altered metabolites and oral/gut microbiota. These observations suggested metabolites and microbiota may become valuable targets for therapeutic and preventive interventions of hypertension.
    Type of Medium: Online Resource
    ISSN: 2072-6643
    URL: Article
    DOI: 10.3390/nu15092074
    Language: English
    Publisher: MDPI AG
    Publication Date: 2023
    detail.hit.zdb_id: 2518386-2
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  • 8
    Online Resource
    Online Resource
    Isolation and Characterization of Sixteen Polymorphic Microsatellite Loci in the Golden Apple Snail Pomacea canaliculata
    MDPI AG ; 2011
    In:  International Journal of Molecular Sciences Vol. 12, No. 9 ( 2011-09-16), p. 5993-5998
    Details
    In: International Journal of Molecular Sciences, MDPI AG, Vol. 12, No. 9 ( 2011-09-16), p. 5993-5998
    Type of Medium: Online Resource
    ISSN: 1422-0067
    URL: Article
    DOI: 10.3390/ijms12095993
    Language: English
    Publisher: MDPI AG
    Publication Date: 2011
    detail.hit.zdb_id: 2019364-6
    SSG: 12
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  • 9
    Online Resource
    Online Resource
    Multi-Branch Deep Residual Network for Single Image Super-Resolution
    MDPI AG ; 2018
    In:  Algorithms Vol. 11, No. 10 ( 2018-09-27), p. 144-
    Details
    In: Algorithms, MDPI AG, Vol. 11, No. 10 ( 2018-09-27), p. 144-
    Abstract: Recently, algorithms based on the deep neural networks and residual networks have been applied for super-resolution and exhibited excellent performance. In this paper, a multi-branch deep residual network for single image super-resolution (MRSR) is proposed. In the network, we adopt a multi-branch network framework and further optimize the structure of residual network. By using residual blocks and filters reasonably, the model size is greatly expanded while the stable training is also guaranteed. Besides, a perceptual evaluation function, which contains three parts of loss, is proposed. The experiment results show that the evaluation function provides great support for the quality of reconstruction and the competitive performance. The proposed method mainly uses three steps of feature extraction, mapping, and reconstruction to complete the super-resolution reconstruction and shows superior performance than other state-of-the-art super-resolution methods on benchmark datasets.
    Type of Medium: Online Resource
    ISSN: 1999-4893
    URL: Article
    DOI: 10.3390/a11100144
    Language: English
    Publisher: MDPI AG
    Publication Date: 2018
    detail.hit.zdb_id: 2455149-1
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  • 10
    Online Resource
    Online Resource
    Retrospective Data Insight into the Global Distribution of Carbapenemase-Producing Pseudomonas aeruginosa
    MDPI AG ; 2021
    In:  Antibiotics Vol. 10, No. 5 ( 2021-05-09), p. 548-
    Details
    In: Antibiotics, MDPI AG, Vol. 10, No. 5 ( 2021-05-09), p. 548-
    Abstract: This study aimed to determine the global distribution and molecular characteristics of carbapenemase-producing Pseudomonas aeruginosa isolates. A total of 328 (11.1%, 328/2953) carbapenemase-producing P. aeruginosa isolates from humans were obtained from public databases as of October 2019. Of which, the blaVIM and blaIMP genes were the most prevalent carbapenemases in the P. aeruginosa isolates. These carbapenemase-producing P. aeruginosa isolates possessed 34 distinct sequence types (STs) and six predominated: ST357, ST823, ST308, ST233, ST175 and ST111. The ST357 and ST823 isolates were primarily found detected in Asia and all ST175 isolates were found in Europe. The ST308, ST233 and ST111 isolates were spread worldwide. Further, all ST823 isolates and the majority of ST111, ST233 and ST175 isolates carried blaVIM but ST357 isolates primarily carried blaIMP. ST308 isolates provide a key reservoir for the spread of blaVIM, blaIMP and blaNDM. WGS analysis revealed that ST111 carried a great diversity of ARG types (n = 23), followed by ST357 (n = 21), ST308 (n = 19), ST233 (n = 18), ST175 (n = 14) and ST823 (n = 10). The ST175 isolates carried a more diversity and frequent of aminoglycoside ARGs, and ST233 isolates harbored more tetracycline ARGs. Our findings revealed that different carbapenem resistance genes were distributed primarily in variant STs of P. aeruginosa isolates, these isolates also possessed an extensive geographical distribution that highlights the need for surveillance studies that detect carbapenemase-producing P. aeruginosa isolates in humans.
    Type of Medium: Online Resource
    ISSN: 2079-6382
    URL: Article
    DOI: 10.3390/antibiotics10050548
    Language: English
    Publisher: MDPI AG
    Publication Date: 2021
    detail.hit.zdb_id: 2681345-2
    SSG: 15,3
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