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  • Wiley  (59)
  • Liu, Xing  (59)
  • 1
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    Curcumin Suppresses Malignant Glioma Cells Growth and Induces Apoptosis by Inhibition of SHH / GLI 1 Signaling Pathway in Vitro and Vivo
    Wiley ; 2013
    In:  CNS Neuroscience & Therapeutics Vol. 19, No. 12 ( 2013-12), p. 926-936
    Details
    In: CNS Neuroscience & Therapeutics, Wiley, Vol. 19, No. 12 ( 2013-12), p. 926-936
    Abstract: To study the role of curcumin on glioma cells via the SHH / GLI 1 pathway in vitro and vivo . Methods The effects of curcumin on proliferation, migration, apoptosis, SHH / GLI 1 signaling, and GLI 1 target genes expression were evaluated in multiple glioma cell lines in vitro . A U87‐implanted nude mice model was used to study the role of curcumin on tumor volume and the suppression efficacy of GLI 1. Results Curcumin showed cytotoxic effects on glioma cell lines in vitro . Both mRNA and protein levels of SHH / GLI 1 signaling ( S hh, S mo, GLI 1) were downregulated in a dose‐ and time‐dependent manner. Several GLI 1‐dependent target genes ( C yclin D 1, B cl‐2, F oxm1) were also downregulated. Curcumin treatment prevented GLI 1 translocating into the cell nucleus and reduced the concentration of its reporter. Curcumin suppressed cell proliferation, colony formation, migration, and induced apoptosis which was mediated partly through the mitochondrial pathway after an increase in the ratio of B ax to B cl2. Intraperitoneal injection of curcumin in vivo reduced tumor volume, GLI 1 expression, the number of positively stained cells, and prolonged the survival period compared with the control group. Conclusion This study shows that curcumin holds a great promise for SHH / GLI 1 targeted therapy against gliomas.
    Type of Medium: Online Resource
    ISSN: 1755-5930 , 1755-5949
    URL: Issue
    URL: Article
    DOI: 10.1111/cns.2013.19.issue-12
    DOI: 10.1111/cns.12163
    Language: English
    Publisher: Wiley
    Publication Date: 2013
    detail.hit.zdb_id: 2423467-9
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  • 2
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    Dual pore‐size sieving in a novel oxygenate‐pillared microporous adsorbent for C6 alkane isomers separation
    Wiley ; 2023
    In:  AIChE Journal Vol. 69, No. 3 ( 2023-03)
    Details
    In: AIChE Journal, Wiley, Vol. 69, No. 3 ( 2023-03)
    Abstract: Adsorbents executing molecular sieving mechanisms for the efficient separation of n ‐hexane (C6) alkane isomers require delicate pore size control, but afford unsatisfactory single‐component separations according to their branch degrees. Herein, we report a novel oxygenate‐pillared microporous adsorbent, MoOFOUR‐Co‐tpb, ([Co(tpb) 2 MoO 4 ], tpb = 1,2,4,5‐tetra(pyridin‐4‐yl) benzene), with three gourd‐shaped channels for dual pore‐size sieving of C6 isomers. In particular, MoOFOUR‐Co‐tpb excludes 2,2‐dimethylbutane, while 3‐methylpentane (3MP) can enter one channel showing a high uptake of 82.6 mg g −1 , contrasting to the n ‐hexane ( n HEX) adsorption by two channels (136 mg g −1 ). This dual pore‐size control strategy renders a record high equilibrium–kinetic combined selectivity for n HEX/3MP (30.2). Moreover, three‐ and five‐component breakthrough experiments confirm the practical separation performances and cycling stability. Multiple theoretical simulations reveal the separation mechanism and adsorption sites.
    Type of Medium: Online Resource
    ISSN: 0001-1541 , 1547-5905
    URL: Issue
    URL: Article
    DOI: 10.1002/aic.v69.3
    DOI: 10.1002/aic.17937
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2020333-0
    detail.hit.zdb_id: 240008-X
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  • 3
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    Dense open metal sites in a microporous metal–organic framework for deep desulfurization with record‐high sulfur dioxide storage density
    Wiley ; 2022
    In:  AIChE Journal Vol. 68, No. 9 ( 2022-09)
    Details
    In: AIChE Journal, Wiley, Vol. 68, No. 9 ( 2022-09)
    Abstract: Dry desulfurization employing porous adsorbents is industrially preferred but efficient capture of sulfur dioxide (SO 2 ) at the ultralow concentration (i.e., 2000 ppm) is exceptionally challenging. Metal–organic frameworks with open metal sites (OMSs) can provide sufficient interactions with SO 2 , which, in turn, will degrade or compromise the structural robustness. Herein, we reported Cu‐ATC that contains dense oppositely positioned Cu OMSs for efficient trace SO 2 removal. Explicitly, Cu‐ATC adsorbs a benchmark amount of SO 2 (5.3 mmol g −1 ) at 0.01 bar with a record‐high SO 2 storage density of 2.23 g cm −3 at ambient conditions. The critical role of OMSs has been confirmed by the partially desolvated sample with declined uptakes and adsorption enthalpy. The desulfurization performances have been validated by multicycle breakthrough experiments even with mimic flue‐gas and water vapor. Computational simulations identify the adsorption sites at the molecular level. Combined with the high stability under various conditions, Cu‐ATC is a potent candidate for industrial implementation.
    Type of Medium: Online Resource
    ISSN: 0001-1541 , 1547-5905
    URL: Issue
    URL: Article
    DOI: 10.1002/aic.v68.9
    DOI: 10.1002/aic.17811
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2020333-0
    detail.hit.zdb_id: 240008-X
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  • 4
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    Single‐Atom Catalyst Aggregates: Size‐Matching is Critical to Electrocatalytic Performance in Sulfur Cathodes
    Wiley ; 2022
    In:  Advanced Science Vol. 9, No. 3 ( 2022-01)
    Details
    In: Advanced Science, Wiley, Vol. 9, No. 3 ( 2022-01)
    Abstract: Electrocatalysis is critical to the performance displayed by sulfur cathodes. However, the constituent electrocatalysts and the sulfur reactants have vastly different molecular sizes, which ultimately restrict electrocatalysis efficiency and hamper device performance. Herein, the authors report that aggregates of cobalt single‐atom catalysts (SACs) attached to graphene via porphyrins can overcome the challenges associated with the catalyst/reactant size mismatch. Atomic‐resolution transmission electron microscopy and X‐ray absorption spectroscopy measurements show that the Co atoms present in the SAC aggregates exist as single atoms with spatially resolved dimensions that are commensurate the sulfur species found in sulfur cathodes and thus fully accessible to enable 100% atomic utilization efficiency in electrocatalysis. Density functional theory calculations demonstrate that the Co SAC aggregates can interact with the sulfur species in a synergistic manner that enhances the electrocatalytic effect and promote the performance of sulfur cathodes. For example, Li–S cells prepared from the Co SAC aggregates exhibit outstanding capacity retention (i.e., 505 mA h g –1 at 0.5 C after 600 cycles) and excellent rate capability (i.e., 648 mA h g −1 at 6 C). An ultrahigh area specific capacity of 12.52 mA h cm −2 is achieved at a high sulfur loading of 11.8 mg cm –2 .
    Type of Medium: Online Resource
    ISSN: 2198-3844 , 2198-3844
    URL: Issue
    URL: Article
    DOI: 10.1002/advs.v9.3
    DOI: 10.1002/advs.202103773
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2808093-2
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  • 5
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    Integrated single‐cell and spatial transcriptomic profiling reveals higher intratumour heterogeneity and epithelial–fibroblast interactions in recurrent bladder cancer
    Wiley ; 2023
    In:  Clinical and Translational Medicine Vol. 13, No. 7 ( 2023-07)
    Details
    In: Clinical and Translational Medicine, Wiley, Vol. 13, No. 7 ( 2023-07)
    Abstract: Recurrent bladder cancer is the most common type of urinary tract malignancy; nevertheless, the mechanistic basis for its recurrence is uncertain. Innovative technologies such as single‐cell transcriptomics and spatial transcriptomics (ST) offer new avenues for studying recurrent tumour progression at the single‐cell level while preserving spatial data. Method This study integrated single‐cell RNA (scRNA) sequencing and ST profiling to examine the tumour microenvironment (TME) of six bladder cancer tissues (three from primary tumours and three from recurrent tumours). Findings scRNA data‐based ST deconvolution analysis revealed a much higher tumour heterogeneity along with TME in recurrent tumours than in primary tumours. High‐resolution ST analysis further identified that while the overall natural killer/T cell and malignant cell count or the ratio of total cells was similar or even lower in the recurrent tumours, a higher interaction between epithelial and immune cells was detected. Moreover, the analysis of spatial communication reveals a marked increase in activity between cancer‐associated fibroblasts (CAFs) and malignant cells, as well as other immune cells in recurrent tumours. Interpretation We observed an enhanced interplay between CAFs and malignant cells in bladder recurrent tumours. These findings were first observed at the spatial level.
    Type of Medium: Online Resource
    ISSN: 2001-1326 , 2001-1326
    URL: Issue
    URL: Article
    DOI: 10.1002/ctm2.v13.7
    DOI: 10.1002/ctm2.1338
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2697013-2
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  • 6
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    Cross‐talk between EGF and BMP 9 signalling pathways regulates the osteogenic differentiation of mesenchymal stem cells
    Wiley ; 2013
    In:  Journal of Cellular and Molecular Medicine Vol. 17, No. 9 ( 2013-09), p. 1160-1172
    Details
    In: Journal of Cellular and Molecular Medicine, Wiley, Vol. 17, No. 9 ( 2013-09), p. 1160-1172
    Abstract: Mesenchymal stem cells ( MSC s) are multipotent progenitors, which give rise to several lineages, including bone, cartilage and fat. Epidermal growth factor ( EGF ) stimulates cell growth, proliferation and differentiation. EGF acts by binding with high affinity to epidermal growth factor receptor ( EGFR ) on the cell surface and stimulating the intrinsic protein tyrosine kinase activity of its receptor, which initiates a signal transduction cascade causing a variety of biochemical changes within the cell and regulating cell proliferation and differentiation. We have identified BMP 9 as one of the most osteogenic BMP s in MSC s. In this study, we investigate if EGF signalling cross‐talks with BMP 9 and regulates BMP 9‐induced osteogenic differentiation. We find that EGF potentiates BMP 9‐induced early and late osteogenic markers of MSC s in vitro , which can be effectively blunted by EGFR inhibitors Gefitinib and Erlotinib or receptor tyrosine kinase inhibitors AG ‐1478 and AG ‐494 in a dose‐ and time‐dependent manner. Furthermore, EGF significantly augments BMP 9‐induced bone formation in the cultured mouse foetal limb explants. In vivo stem cell implantation experiment reveals that exogenous expression of EGF in MSC s can effectively potentiate BMP 9‐induced ectopic bone formation, yielding larger and more mature bone masses. Interestingly, we find that, while EGF can induce BMP 9 expression in MSC s, EGFR expression is directly up‐regulated by BMP 9 through Smad1/5/8 signalling pathway. Thus, the cross‐talk between EGF and BMP 9 signalling pathways in MSC s may underline their important roles in regulating osteogenic differentiation. Harnessing the synergy between BMP 9 and EGF should be beneficial for enhancing osteogenesis in regenerative medicine.
    Type of Medium: Online Resource
    ISSN: 1582-1838 , 1582-4934
    URL: Issue
    URL: Article
    DOI: 10.1111/jcmm.2013.17.issue-9
    DOI: 10.1111/jcmm.12097
    Language: English
    Publisher: Wiley
    Publication Date: 2013
    detail.hit.zdb_id: 2076114-4
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  • 7
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    Nitrogen‐Doped Accordion‐Like Soft Carbon Anodes with Exposed Hierarchical Pores for Advanced Potassium‐Ion Hybrid Capacitors
    Wiley ; 2021
    In:  Advanced Functional Materials Vol. 31, No. 23 ( 2021-06)
    Details
    In: Advanced Functional Materials, Wiley, Vol. 31, No. 23 ( 2021-06)
    Abstract: Soft carbon (SC) is a promising anode material for potassium‐ion hybrid capacitors (PIHCs), but there are limited K + storage sites in common SC due to a skin‐like carbon film covering on the surface. To address this issue, a simple oxidization method to completely remove the skin‐like carbon film is reported and a novel accordion‐like architecture of SC (ASC) is constructed with a hierarchical porous framework composed of micropores, mesopores, and macropores, all of which can be exposed to K + electrolytes for enhanced energy storage. Importantly, this exposed structure facilitates pseudocapacitance modification by electro‐deposition of highly electrochemically active nitrogen‐doped graphene quantum dots (N‐GQDs) to enhance kinetic performance and additional K + storage. After annealing treatment to regulate N‐doping type, the accordion‐like N‐GQD@ASC‐500 exhibits excellent reversible capacity of 360 mAh g −1 as well as superior rate capability and cycle stability. Kinetic, in situ Raman/electrochemical impedance spectroscopy analysis, and density functional theory calculation elucidate the K + storage mechanism. As expected, the PIHC assembled with N‐GQD@ASC‐500 anode and porous carbon cathode delivers an ultrahigh energy/power density (171 Wh kg −1 and 20 000 W kg −1 ) with long cycle life. This work suggests that ASC is a promising anode material for designing of high‐performance PIHCs.
    Type of Medium: Online Resource
    ISSN: 1616-301X , 1616-3028
    URL: Issue
    URL: Article
    DOI: 10.1002/adfm.v31.23
    DOI: 10.1002/adfm.202101470
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2029061-5
    detail.hit.zdb_id: 2039420-2
    SSG: 11
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  • 8
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    One‐step purification of ethylene from acetylene and carbon dioxide by ultramicroporous carbons
    Wiley ; 2023
    In:  AIChE Journal Vol. 69, No. 6 ( 2023-06)
    Details
    In: AIChE Journal, Wiley, Vol. 69, No. 6 ( 2023-06)
    Abstract: The one‐step adsorptive separation of high‐purity ethylene (C 2 H 4 ) from a ternary gas mixture (C 2 H 2 /C 2 H 4 /CO 2 ) is challenging and has not been reported on porous carbons. Herein, we report camphor seeds husk‐derived ultramicroporous carbons (CSHs) show high affinities toward acetylene (C 2 H 2 ) and carbon dioxide (CO 2 ) over C 2 H 4 . The optimized CSH‐2‐700 with high heteroatom contents and centered pore size distributions shows high C 2 H 2 adsorption capacity (2.24 mmol g −1 ) and record ideal adsorbed solution theory (IAST) C 2 H 2 /C 2 H 4 selectivity (10.2) among one‐step C 2 H 4 purification adsorbents. Meanwhile, CSH carbons are the only carbon adsorbents that preferentially adsorb CO 2 over C 2 H 4 , with a CO 2 /C 2 H 4 selectivity of 1.9 under ambient conditions. Furthermore, dynamic breakthrough experiments verified its feasibility for one‐step C 2 H 4 purification from a three‐component C 2 H 2 /C 2 H 4 /CO 2 gas‐mixture.
    Type of Medium: Online Resource
    ISSN: 0001-1541 , 1547-5905
    URL: Issue
    URL: Article
    DOI: 10.1002/aic.v69.6
    DOI: 10.1002/aic.18046
    Language: English
    Publisher: Wiley
    Publication Date: 2023
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  • 9
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    Dissociative role for dorsal hippocampus in mediating heroin self‐administration and relapse through CDK5 and RhoB signaling revealed by proteomic analysis
    Wiley ; 2017
    In:  Addiction Biology Vol. 22, No. 6 ( 2017-11), p. 1731-1742
    Details
    In: Addiction Biology, Wiley, Vol. 22, No. 6 ( 2017-11), p. 1731-1742
    Abstract: Addiction is characterized by drug craving, compulsive drug taking and relapse, which is attributed to aberrant neuroadaptation in brain regions implicated in drug addiction, induced by changes in gene and protein expression in these regions after chronic drug exposure. Accumulating evidence suggests that the dorsal hippocampus (DH) plays an important role in mediating drug‐seeking and drug‐taking behavior and relapse. However, the molecular mechanisms underlying these effects of the DH are unclear. In the present study, we employed a label‐free quantitative proteomic approach to analyze the proteins altered in the DH of heroin self‐administering rats. A total of 4015 proteins were quantified with high confidence, and 361 proteins showed significant differences compared with the saline control group. Among them, cyclin‐dependent kinase 5 (CDK5) and ras homolog family member B (RhoB) were up‐regulated in rats with a history of extended access to heroin. Functionally, inhibition of CDK5 in the DH enhanced heroin self‐administration, indicating that CDK5 signaling in the DH acts as a homeostatic compensatory mechanism to limit heroin‐taking behavior, whereas blockade of the Rho‐Rho kinase (ROCK) pathway attenuated context‐induced heroin relapse, indicating that RhoB signaling in the DH is required for the retrieval (recall) of addiction memory. Our findings suggest that manipulation of CDK5 signaling in the DH may be essential in determining vulnerability to opiate taking, whereas manipulation of RhoB signaling in the DH may be essential in determining vulnerability to relapse. Overall, the present study suggests that the DH can exert dissociative effects on heroin addiction through CDK5 and RhoB signaling.
    Type of Medium: Online Resource
    ISSN: 1355-6215 , 1369-1600
    URL: Issue
    URL: Article
    DOI: 10.1111/adb.2017.22.issue-6
    DOI: 10.1111/adb.12435
    Language: English
    Publisher: Wiley
    Publication Date: 2017
    detail.hit.zdb_id: 1495537-4
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  • 10
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    Biased gene expression reveals the contribution of subgenome to altitude adaptation in allopolyploid Isoetes sinensis
    Wiley ; 2022
    In:  Ecology and Evolution Vol. 12, No. 12 ( 2022-12)
    Details
    In: Ecology and Evolution, Wiley, Vol. 12, No. 12 ( 2022-12)
    Abstract: Allopolyploids are believed to inherit the genetic characteristics of its progenitors and exhibit stronger adaptability and vigor. The allotetraploid Isoetes sinensis was formed by the natural hybridization and polyploidization of two diploid progenitors, Isoetes taiwanensis and Isoetes yunguiensis , and was believed to have the potential to adapt to plateau environments. To explore the expression pattern of homoeologous genes and their contributions to altitude adaptation, we transplanted natural allotetraploid I. sinensis (TnTnYnYn) along the altitude gradient for a long‐term, and harvested them in summer and winter, respectively. One year after transplanting, it still lived well, even in the extreme environment of the Qinghai‐Tibet Plateau. Then, we performed high‐throughput RNA sequencing to measure their gene expression level. A total of 7801 homoeologous genes were expressed, among which 5786 were identified as shared expression in different altitudes and seasons. We further found that altitude variations could change the subgenome bias trend of I. sinensis , but season could not. Moreover, the functions of uniquely expressed genes indicated that temperature might be an important restrictive factor during the adaptation process. Through the analysis of DEGs and uniquely expressed genes, we found that Y subgenome provided more contributions to high altitude adaptation than T subgenome. These adaptive traits to high altitude may be inherited from its plateau progenitor I. yunguiensis . Through weighted gene co‐expression network analysis, pentatricopeptide repeats gene family and glycerophospholipid metabolism pathway were considered to play important roles in high‐altitude adaptation. Totally, this study will enrich our understanding of allopolyploid in environmental adaptation.
    Type of Medium: Online Resource
    ISSN: 2045-7758 , 2045-7758
    URL: Issue
    URL: Article
    DOI: 10.1002/ece3.v12.12
    DOI: 10.1002/ece3.9677
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2635675-2
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