In:
Environmental Toxicology, Wiley, Vol. 37, No. 7 ( 2022-07), p. 1642-1652
Abstract:
Exposure to air pollution has been closely associated with some cardiovascular disease. One of the mechanisms of PM 2.5 ‐mediated heart injury may be to promote inflammation. We aim to investigate whether the main extract of Houttuynia cordata , 2‐undecanone, can prevent the inflammation caused by PM 2.5 , and to reveal the underlying mechanisms. The results showed that PM 2.5 increased the expression of certain inflammatory cytokines, and caused oxidative damage in BALB/c mice and H9C2 cells. Supplementation with 2‐undecanone attenuated this PM 2.5 ‐induced inflammatory injury and oxidative damage. Further, we elucidated that the protective effect of 2‐undecanone may be associated with NF‐κB and Nrf2/HO‐1 pathways. The NF‐κB pathway was distinctly activated after treated by PM 2.5 , which can be blocked by 2‐undecanone, accompanied by increasing Nrf2 and HO‐1 levels. To figure out the relationship between NF‐κB and Nrf2/HO‐1 pathways, we knocked down Nrf2 gene. NF‐κB pathway proteins and downstream inflammatory cytokines were significantly increased after treatment with PM 2.5 , while 2‐undecanone could decrease expression of these proteins. In conclusion, it is possible that 2‐undecanone can induce the expression of the antioxidant enzyme HO‐1 by activating Nrf2, thereby reducing NF‐κB pathway and inflammatory damage of mouse myocardium caused by PM 2.5 exposure.
Type of Medium:
Online Resource
ISSN:
1520-4081
,
1522-7278
Language:
English
Publisher:
Wiley
Publication Date:
2022
detail.hit.zdb_id:
2027534-1
detail.hit.zdb_id:
1463449-1
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