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  • 1
    Online Resource
    Online Resource
    A prospective, multi-center, single-arm study of a novel double-disc left atrial appendage closure system: The periprocedural and mid-term outcomes (english version)
    Medknow ; 2021
    In:  International Journal of Heart Rhythm Vol. 6, No. 1 ( 2021), p. 60-
    Details
    In: International Journal of Heart Rhythm, Medknow, Vol. 6, No. 1 ( 2021), p. 60-
    Type of Medium: Online Resource
    ISSN: 2352-4197
    URL: Article
    DOI: 10.4103/ijhr.ijhr_5_21
    Language: English
    Publisher: Medknow
    Publication Date: 2021
    detail.hit.zdb_id: 3012262-4
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  • 2
    Online Resource
    Online Resource
    Effectiveness of chemotherapy on prognosis of elderly breast cancer: A retrospective cohort study based on SEER database.
    American Society of Clinical Oncology (ASCO) ; 2022
    In:  Journal of Clinical Oncology Vol. 40, No. 16_suppl ( 2022-06-01), p. e12525-e12525
    Details
    In: Journal of Clinical Oncology, American Society of Clinical Oncology (ASCO), Vol. 40, No. 16_suppl ( 2022-06-01), p. e12525-e12525
    Abstract: e12525 Background: The estimated population of breast cancer older than 70 years is over 80,000 new onset cases in 2019 and keep increasing. Currently, the proportion of standard chemotherapy for elderly patients was much lower than that for young patients, due to shorter life expectancy, more comorbidities, and concerns over increased toxicities and reduced tolerance. Till now, few evidences from clinical trials could support the use of chemotherapy for elderly patients, as also indicated by current guidelines for adjuvant chemotherapy. The effectiveness of chemotherapy for elderly breast cancer remains to be further verified. Methods: We identified 75,525 female breast cancer patients aged 70 years and older in the Surveillance, Epidemiology, and End Results (SEER) database from January 1, 2010, to December 31, 2016, and excluded those patients with secondary, metastatic, or bilateral breast cancer, not confirmed by pathology, lacking of key information, dead or loss to follow-up in 6 months after diagnosis. Propensity score matching (PSM) (PSM ratio: 1:1, caliper: 0.2* standard deviation of propensity score) was applied to construct balanced cohorts with or without chemotherapy based on demographic and pathophysiological characteristics. Kaplan-Meier analysis, multivariable Cox proportional model, and subgroup analysis were performed to evaluate the effectiveness of chemotherapy on overall survival (OS) and breast cancer-specific survival (BCSS). Results: A total of 33,177 eligible patients were included, of them, 5273 (15.89%) received chemotherapy. Through PSM, 8360 patients were successfully matched and almost reached balances between groups. In matched dataset, patients receiving chemotherapy exhibited a better prognosis on OS and BCSS (the 5-year survival rate, OS: 0.80 [0.78-0.82] with chemotherapy vs. 0.71[0.69-0.73] control; BCSS: 0.88 [0.87-0.89] with chemotherapy vs. 0.85 [0.84-0.86] ; both log-rank test, P 〈 0.001); in multivariable Cox analysis, chemotherapy was associated with a 35% and 21% risk reduction on OS (HR [95%CI]: 0.65[0.59-0.72] ) and BCSS (0.79[0.69-0.91]), respectively. Furthermore, subgroups with HER-2 positive, or more lymph nodes involved, were inclined to benefit more from chemotherapy. Conclusions: Our study provided additional evidences that chemotherapy may improve the prognosis of elderly breast cancer, especially for those subpopulations benefit more from chemotherapy treatment.
    Type of Medium: Online Resource
    ISSN: 0732-183X , 1527-7755
    URL: Article
    DOI: 10.1200/JCO.2022.40.16_suppl.e12525
    RVK:
    XA 52760
    RVK:
    XA 10000
    Language: English
    Publisher: American Society of Clinical Oncology (ASCO)
    Publication Date: 2022
    detail.hit.zdb_id: 2005181-5
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  • 3
    Online Resource
    Online Resource
    COVID-19 Vaccination Status and Hesitancy among Breast Cancer Patients after Two Years of Pandemic: A Cross-Sectional Survey
    MDPI AG ; 2022
    In:  Vaccines Vol. 10, No. 9 ( 2022-09-15), p. 1530-
    Details
    In: Vaccines, MDPI AG, Vol. 10, No. 9 ( 2022-09-15), p. 1530-
    Abstract: Background: Patients with cancer show greater susceptibility and vulnerability to severe acute respiratory syndrome coronavirus 2 infection. However, data on the vaccination status among patients with breast cancer and any structured analysis of the factors influencing patients’ decisions regarding vaccines are lacking. Methods: This cross-sectional study on patients with breast cancer in China was conducted from 1 June 2022, to 17 June 2022. Every participant completed an online questionnaire about their vaccination status and any adverse reactions, and a scale based on the Health Belief Model (HBM) to assess the vaccination status of respondents and their willingness to receive following doses or boosters. Results: Among the 1132 participants, 55.2% had received a COVID-19 vaccine. The incidence of adverse events per dose was around 40%. Vaccine hesitancy of 61.9% was observed among patients who had not fully received three doses of vaccine or boosters. The only variable found to be associated with vaccine hesitancy was time since diagnosis (p 〈 0.05). In the HBM scale, vaccine hesitancy was closely related to a low level of perceived susceptibility, a low level of perceived benefit, a high level of perceived barriers and a low level of agreement with doctors’ advice. Conclusions: For patients with breast cancer, perceived susceptibility, benefits and barriers should be prioritized, and the advice from authoritative doctors is a vital cue to action.
    Type of Medium: Online Resource
    ISSN: 2076-393X
    URL: Article
    DOI: 10.3390/vaccines10091530
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2703319-3
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  • 4
    Online Resource
    Online Resource
    A nomogram for predicting breast cancer specific survival in elderly patients with breast cancer: a SEER population-based analysis
    Springer Science and Business Media LLC ; 2023
    In:  BMC Geriatrics Vol. 23, No. 1 ( 2023-09-25)
    Details
    In: BMC Geriatrics, Springer Science and Business Media LLC, Vol. 23, No. 1 ( 2023-09-25)
    Abstract: The number of elderly patients diagnosed with breast cancer is increasing worldwide. However, treatment decisions for these patients are highly variable. Although researchers have identified the effects of surgery, radiotherapy, endocrine therapy, and chemotherapy in elderly patients with breast cancer, clinicians still struggle to make appropriate decisions for these patients. Methods We identified 75,525 female breast cancer patients aged ≥ 70 years in the Surveillance, Epidemiology, and End Results (SEER) database treated between January 1, 2010, and December 31, 2016. The patients were further divided into training and testing cohorts. The cumulative occurrence of breast cancer-specific deaths (BCSDs) and other cause-specific deaths (OCSD) was calculated using the cumulative incidence function. In the univariate analysis, risk factors were screened using the Fine-Gray model. In the multivariate analysis for competing risks, the sub-distribution hazard ratio with a 95% confidence interval for each independent predictor associated with BCSD was calculated for the construction of nomograms. Based on the above analyses, a competing risk nomogram was constructed to predict the probability of BCSD in the 1st, 3rd, and 5th years after treatment. During validation, the concordance index (C-index) was selected to quantify the predictive ability of the competing risk model. Results A total of 33,118 patients were included in this study, with 24,838 in the training group and 8,280 in the testing group. Age, race, marital status, cancer grade, tumor stage, node stage, estrogen receptor status, progesterone receptor status, human epidermal growth factor receptor--2 status, and treatment including surgery, radiation, and chemotherapy were used to establish a nomogram. The C-index of 0.852 (0.842-0.862) in the training cohort and 0.876 (0.868-0.892) in the testing cohort indicated satisfactory discriminative ability of the nomogram. Calibration plots showed favorable consistency between the nomogram predictions and actual observations in both the training and validation cohorts. Conclusions Our study identified independent predictors of BCSD in elderly patients with breast cancer. A prognostic nomogram was developed and validated to aid clinical decision-making.
    Type of Medium: Online Resource
    ISSN: 1471-2318
    URL: Article
    DOI: 10.1186/s12877-023-04280-8
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2023
    detail.hit.zdb_id: 2059865-8
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  • 5
    Online Resource
    Online Resource
    Pattern of Time-to-Surgery in Patients With Breast Cancer at Different Stages of the COVID-19 Pandemic
    Frontiers Media SA ; 2022
    In:  Frontiers in Oncology Vol. 11 ( 2022-1-12)
    Details
    In: Frontiers in Oncology, Frontiers Media SA, Vol. 11 ( 2022-1-12)
    Abstract: The management of cancer surgeries is under unprecedented challenges during the COVID-19 pandemic, and the breast cancer patients may face a time-delay in the treatment. This retrospective study aimed to present the pattern of time-to-surgery (TTS) and analyze the features of breast cancer patients under the different stages of the COVID-19 pandemic. Methods Patients who received surgeries for breast cancers at West China Hospital between February 15, 2020 and April 30, 2020 (the outbreak and post-peak stages), and between March 10, 2021 and May 25, 2021 (the normalization stage) were included. TTS was calculated as the time interval between the pathological diagnosis and surgical treatment of breast cancer patients. And the pandemic was divided into three stages based on the time when the patients were pathologically diagnosed and the severity of pandemic at that time point. TTS, demographic and clinicopathological features were collected from medical records. Results A total of 367 patients were included. As for demographic features, it demonstrated statistically significant differences in insurance type ( p & lt;0.001) and regular screening ( p & lt;0.001), as well as age ( p =0.013) and menstrual status ( p =0.004). As for clinicopathological features, axillary involvement ( p =0.019) was a factor that differed among three stages. The overall TTS was 23.56 ± 21.39 days. TTS for patients who were diagnosed during the outbreak of COVID-19 were longer than those diagnosed during pandemic post-peak and normalization stage ( p & lt;0.001). Pandemic stage ( p & lt;0.001) and excision biopsy before surgery (OR, 6.459; 95% CI, 2.225-18.755; p =0.001) were markedly correlated with the TTS of patients. Conclusions TTS of breast cancer patients significantly varied in different stages of the COVID-19 pandemic. And breast cancer patients’ daily lives and disease treatments were affected by the pandemic in many aspects, such as health insurance access, physical screening and change of therapeutic schedules. As the time-delay may cause negative influences on patients’ disease, we should minimize the occurrence of such time-delay. It is vital to come up with comprehensive measures to deal with unexpected situations in case the pandemic occurs.
    Type of Medium: Online Resource
    ISSN: 2234-943X
    URL: Article
    DOI: 10.3389/fonc.2021.820638
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2649216-7
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  • 6
    Online Resource
    Online Resource
    Diagnostic value of core needle biopsy for determining HER2 status in breast cancer, especially in the HER2-low population
    Springer Science and Business Media LLC ; 2023
    In:  Breast Cancer Research and Treatment Vol. 197, No. 1 ( 2023-01), p. 189-200
    Details
    In: Breast Cancer Research and Treatment, Springer Science and Business Media LLC, Vol. 197, No. 1 ( 2023-01), p. 189-200
    Abstract: The status of human epidermal growth factor receptor 2 (HER2) is important for treatment decision-making of breast cancer and was commonly determined by core needle biopsy (CNB). The concordance of CNB with surgical excision biopsy (SEB) has been verified, but remain unclear according to the newly developed classification of HER2 status. Our study aimed to re-evaluate the diagnostic value of CNB for determining HER2 status in breast cancer, especially in the HER2-low population. Methods Eligible breast cancer patients in West China Hospital between January 1, 2007 and December 31, 2021 were enrolled consecutively and data were extracted from the Hospital Information System. The agreement of HER2 status between CNB and SEB was calculated by concordance rate and κ statistics, as well as the sensitivity, specificity, positive, and negative predictive values (PPV & NPV). Logistic models were used to explore potential factors associated with the discordance between both tests. Results Of 1829 eligible patients, 1097 (60.0%) and 1358 (74.2%) were consistent between CNB and SEB by pathological and clinical classifications, respectively, with κ value being 0.46 (0.43–0.49) and 0.57 (0.53–0.60). The sensitivity (50.9%–52.7%) and PPV (50.5%-55.2%) of CNB were especially low among IHC 1+ and 2+/ISH - subgroups by pathological classifications; however, it showed the highest sensitivity (77.5%) and the lowest specificity (73.9%) in HER2-low population by clinical classifications. Advanced N stages might be a stable indicator for the discordance between both tests. Conclusion The diagnostic value of CNB was limited for determining HER2 status in breast cancer, especially in HER2-low population.
    Type of Medium: Online Resource
    ISSN: 0167-6806 , 1573-7217
    URL: Article
    DOI: 10.1007/s10549-022-06781-3
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2023
    detail.hit.zdb_id: 2004077-5
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  • 7
    Online Resource
    Online Resource
    The Effect of Antioxidant Vitamins on Patients With Diabetes and Albuminuria: A Meta-Analysis of Randomized Controlled Trials
    Elsevier BV ; 2020
    In:  Journal of Renal Nutrition Vol. 30, No. 2 ( 2020-03), p. 101-110
    Details
    In: Journal of Renal Nutrition, Elsevier BV, Vol. 30, No. 2 ( 2020-03), p. 101-110
    Type of Medium: Online Resource
    ISSN: 1051-2276
    URL: Article
    DOI: 10.1053/j.jrn.2019.06.011
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2020
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  • 8
    Online Resource
    Online Resource
    Percutaneous Left Atrial Appendage Closure With a Novel LAA Occluder for Stroke Prevention in Atrial Fibrillation
    Elsevier BV ; 2022
    In:  JACC: Asia Vol. 2, No. 5 ( 2022-10), p. 547-556
    Details
    In: JACC: Asia, Elsevier BV, Vol. 2, No. 5 ( 2022-10), p. 547-556
    Type of Medium: Online Resource
    ISSN: 2772-3747
    URL: Article
    DOI: 10.1016/j.jacasi.2022.04.009
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2022
    detail.hit.zdb_id: 3096596-2
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  • 9
    Online Resource
    Online Resource
    Behavior and fate of microcystin-LR in soils amended with biochar and peat
    Elsevier BV ; 2022
    In:  Environmental Pollution Vol. 310 ( 2022-10), p. 119913-
    Details
    In: Environmental Pollution, Elsevier BV, Vol. 310 ( 2022-10), p. 119913-
    Type of Medium: Online Resource
    ISSN: 0269-7491
    URL: Article
    DOI: 10.1016/j.envpol.2022.119913
    RVK:
    AR 10100
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2022
    detail.hit.zdb_id: 280652-6
    detail.hit.zdb_id: 2013037-5
    SSG: 12
    SSG: 14
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  • 10
    Online Resource
    Online Resource
    Enhanced secondary pollution offset reduction of primary emissions during COVID-19 lockdown in China
    Oxford University Press (OUP) ; 2021
    In:  National Science Review Vol. 8, No. 2 ( 2021-02-10)
    Details
    In: National Science Review, Oxford University Press (OUP), Vol. 8, No. 2 ( 2021-02-10)
    Abstract: To control the spread of the 2019 novel coronavirus (COVID-19), China imposed nationwide restrictions on the movement of its population (lockdown) after the Chinese New Year of 2020, leading to large reductions in economic activities and associated emissions. Despite such large decreases in primary pollution, there were nonetheless several periods of heavy haze pollution in eastern China, raising questions about the well-established relationship between human activities and air quality. Here, using comprehensive measurements and modeling, we show that the haze during the COVID lockdown was driven by enhancements of secondary pollution. In particular, large decreases in NOx emissions from transportation increased ozone and nighttime NO3 radical formation, and these increases in atmospheric oxidizing capacity in turn facilitated the formation of secondary particulate matter. Our results, afforded by the tragic natural experiment of the COVID-19 pandemic, indicate that haze mitigation depends upon a coordinated and balanced strategy for controlling multiple pollutants.
    Type of Medium: Online Resource
    ISSN: 2095-5138 , 2053-714X
    URL: Article
    DOI: 10.1093/nsr/nwaa137
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2021
    detail.hit.zdb_id: 2745465-4
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