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  • Trans Tech Publications, Ltd.  (3)
  • Liu, Rui  (3)
  • Wang, Chen  (3)
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  • Trans Tech Publications, Ltd.  (3)
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  • 1
    Online Resource
    Online Resource
    Preparation and Characterization of Biodegradable β-TCP-Based Composite Microspheres as Bone Tissue Engineering Scaffolds
    Trans Tech Publications, Ltd. ; 2007
    In:  Key Engineering Materials Vol. 336-338 ( 2007-4), p. 1646-1649
    Details
    In: Key Engineering Materials, Trans Tech Publications, Ltd., Vol. 336-338 ( 2007-4), p. 1646-1649
    Abstract: Since a small globular particle was first used as support for three-dimensional (3D) growth of anchorage-dependent cells in suspended cultures, a variety of microspheres as tissue engineering scaffolds have been developed. In this paper, β-TCP and chitosan were selected as the components of microspheres due to their biodegradability and osteogenic properties. The biodegradable β-TCP/chitosan composite microspheres were prepared by a solid-in-water-in-oil (s/w/o) emulsion cross-linking method in this paper. The size distribution, surface morphology, and microstructure of the microspheres were evaluated. Scanning electron microscopy revealed that the size of the microspheres with good spherical morphology was distributed in the range of 50~200μm. In vitro immersion experiments were carried out to evaluate the degradability of the microspheres, and the results demonstrated that the chitosan/β-TCP composite microspheres were potential materials as tissue engineering scaffolds for bone repair.
    Type of Medium: Online Resource
    ISSN: 1662-9795
    URL: Issue
    URL: Article
    DOI: 10.4028/www.scientific.net/KEM.336-338
    DOI: 10.4028/www.scientific.net/KEM.336-338.1646
    Language: Unknown
    Publisher: Trans Tech Publications, Ltd.
    Publication Date: 2007
    detail.hit.zdb_id: 2073306-9
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    Online Resource
  • 2
    Online Resource
    Online Resource
    Physicochemical and Mechanical Properties of Composite of Chitosan Microspheres/Calcium Phosphate Cement
    Trans Tech Publications, Ltd. ; 2007
    In:  Key Engineering Materials Vol. 336-338 ( 2007-4), p. 1654-1657
    Details
    In: Key Engineering Materials, Trans Tech Publications, Ltd., Vol. 336-338 ( 2007-4), p. 1654-1657
    Abstract: The aim of this work is to improve the mechanical properties of calcium phosphate bone cement (CPC) by appending chitosan microspheres to CPC base. That chitosan degrades rapidly than bone cement has been proved by previous investigations. Porous CPC has low compressive strength because of the pores in it weakening the structure. Additive chitosan microspheres can improve the mechanical properties by bearing the compress with the CPC base and produce pores after degradation. This study investigates the effect of chitosan microspheres on the setting time, mechanical properties, phase evolution and morphology of CPC. The additive proportion of chitosan microspheres ranges from 0 wt% to 30 wt%. Compared with original CPC, the modified CPC has higher compressive strength, without significantly affecting the chemical properties. The phase composition of the CPC is tested by XRD. The microstructures of CPC are observed using SEM. The final setting times range from 5~15 minutes and can be modulated by using different liquid and powder (L/P) ratio.
    Type of Medium: Online Resource
    ISSN: 1662-9795
    URL: Issue
    URL: Article
    DOI: 10.4028/www.scientific.net/KEM.336-338
    DOI: 10.4028/www.scientific.net/KEM.336-338.1654
    Language: Unknown
    Publisher: Trans Tech Publications, Ltd.
    Publication Date: 2007
    detail.hit.zdb_id: 2073306-9
    Location Call Number Limitation Availability
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    Online Resource
  • 3
    Online Resource
    Online Resource
    In Vivo Behavior of Injectable Fast-Setting Calcium Phosphate Cement
    Trans Tech Publications, Ltd. ; 2007
    In:  Key Engineering Materials Vol. 336-338 ( 2007-4), p. 1625-1627
    Details
    In: Key Engineering Materials, Trans Tech Publications, Ltd., Vol. 336-338 ( 2007-4), p. 1625-1627
    Abstract: The in vivo study was performed to evaluate the biocompatibility and osteogenous ability of injectable fast-setting calcium phosphate cement (CPC). Eighteen four-week-old New Zealand white rabbits were divided into six groups randomly, three in each group. According to the principle of selfcontrast at the same time, cavities of 5mm in diameter and 6mm in depth were drilled in femoral condyle of rabbits. The materials were implanted into cavities of the left leg, the right leg as the blank control group. Rabbits were sacrificed at 2, 4, 8, 12, 16 and 24 weeks after surgery. The microstructure of specimens was observed using ESEM. The results showed that injectable fast-setting CPC had good fluidity and plasticity; it could be injected into bone defects and fast-set in situ. The start setting time was 5-8 min and the compressive strength was 25-30 MPa. The CPC had good biocompatibility and osteoconductivity, and benefited to the repair of bone defects.
    Type of Medium: Online Resource
    ISSN: 1662-9795
    URL: Issue
    URL: Article
    DOI: 10.4028/www.scientific.net/KEM.336-338
    DOI: 10.4028/www.scientific.net/KEM.336-338.1625
    Language: Unknown
    Publisher: Trans Tech Publications, Ltd.
    Publication Date: 2007
    detail.hit.zdb_id: 2073306-9
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
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