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  • Ovid Technologies (Wolters Kluwer Health)  (4)
  • Liu, Qingzhi  (4)
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  • Ovid Technologies (Wolters Kluwer Health)  (4)
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  • 1
    Online Resource
    Online Resource
    A dosimetric evaluation of flattening filter-free volumetric modulated arc therapy for postoperative treatment of cervical cancer ⁎
    Ovid Technologies (Wolters Kluwer Health) ; 2016
    In:  Oncology and Translational Medicine Vol. 2, No. 4 ( 2016-08), p. 179-184
    Details
    In: Oncology and Translational Medicine, Ovid Technologies (Wolters Kluwer Health), Vol. 2, No. 4 ( 2016-08), p. 179-184
    Abstract: The aim of the study was to compare flattening filter-free (FFF) beams and conventional flattening filter (FF) beams in volumetric modulated arc therapy (VMAT) for cervical cancer after surgery, through a retrospective planning study. Methods VMAT plans of FFF beams and normal FF beams were designed for a cohort of 15 patients. The prescribed dose was 45 Gy to 1.8 Gy per fraction, and at least 95% of the planning target volume received this dose. Doses were computed with a commercially available treatment planning system using a Monte Carlo (MC) algorithm. Plans were compared according to dose-volume histogram analysis in terms of planning target volume homogeneity and conformity indices (HI and CI), as well as organs at risk (OAR) dose and volume parameters. Results FFF-VMAT was similar to FF-VMAT in terms of CI, but inferior to FF-VMAT considering HI. No statistically differences were observed between FFF-VMAT and FF-VMAT in following organ at risks including pelvic bone marrow, small bowel, bladder, rectum, and normal tissue (NT). . Conclusion For patients with cervical cancer after hysterectomy, the FFF beam achieved target and OAR dose distribution similar to that of the FF beam. Reduction of beam-on time in cervical cancer is beneficial.
    Type of Medium: Online Resource
    ISSN: 2095-9621
    URL: Article
    DOI: 10.1007/s10330-016-0154-8
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2016
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  • 2
    Online Resource
    Online Resource
    Dosimetric comparison of different multileaf collimators in volumetric modulated arc therapy for malignant pleural mesothelioma
    Ovid Technologies (Wolters Kluwer Health) ; 2015
    In:  Oncology and Translational Medicine Vol. 1, No. 4 ( 2015-08), p. 186-189
    Details
    In: Oncology and Translational Medicine, Ovid Technologies (Wolters Kluwer Health), Vol. 1, No. 4 ( 2015-08), p. 186-189
    Abstract: The aiom of the study was to compare the impacts of two types of multileaf collimators (MLC) [standard MLC with a width of 10 mm (sMLC) and micro-MLC with a width of 5 mm (mMLC)] on volumetric modulated arc therapy (VMAT) planning for malignant pleural mesothelioma. Methods VMAT for ten patients with inoperable malignant pleural mesotheliomas was retrospectively planned with the sMLC and mMLC. Histogram-based dose-volume parameters of the planning target volume (PTV) [conformity index (CI) and homogeneous index (HI)] and organs-at-risk were compared for VMAT plans with sMLC (sMLC-VMAT) and mMLC (mMLC-VMAT). Results The mMLC-VMAT plans were more efficient (average delivery time: 2.67±1.49 min) than the sMLC-VMAT plans (average delivery time: 4.21 ± 2.03 min; P 〈 0.05). Moreover, compared to the sMLC plans, the mMLC plans demonstrated advantages in the dose coverage of the PTV (CI 0.75 ± 0.08 vs 0.73 ± 0.09; HI 1.09 ± 0.02 vs 1.10 ± 0.02), although the difference was not statistically significant ( P 〉 0.05). In addition, significant dose sparing in the fraction of the ipsilateral lung volume receiving 〉 20 Gy (V20; 54.72 ± 27.08 vs 58.52 ± 29.30) and 〉 30 Gy (V30; 42.74 ± 27.86 vs 46.86 ± 31.49) radiation, respectively, was observed for the mMLC plans ( P 〈 0.05). Conclusion Comparing sMLC-VMAT and mMLC-VMAT not only demonstrated the higher efficiency and better optimal target coverage of mMLC-VMAT, but also considerably improved the dose sparing of the ipsilateral lung in the VMAT plans for malignant pleural mesothelioma.
    Type of Medium: Online Resource
    ISSN: 2095-9621
    URL: Article
    DOI: 10.1007/s10330-014-0042-z
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2015
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  • 3
    Online Resource
    Online Resource
    Dosimetric analysis of tomotherapy-based intensity-modulated radiotherapy with and without bone marrow sparing for the treatment of cervical cancer ⁎
    Ovid Technologies (Wolters Kluwer Health) ; 2015
    In:  Oncology and Translational Medicine Vol. 1, No. 3 ( 2015-06), p. 135-139
    Details
    In: Oncology and Translational Medicine, Ovid Technologies (Wolters Kluwer Health), Vol. 1, No. 3 ( 2015-06), p. 135-139
    Abstract: The aim of the study was to compare tomotherapy-based bone marrow-sparing intensity-modulated radiotherapy (BMS-IMRT) with intensity-modulated radiotherapy (IMRT) without entering the pelvic bone marrow as a planning constraint in the treatment of cervical cancer after hysterectomy. Methods BMS-IMRT and IMRT plans were designed for a cohort of nine patients. The prescribed dose was 45 Gy in 1.8 Gy daily fractions, and 95% of the planned target volume received this dose. The doses were computed using a commercially available treatment planning system with the convolution/superposition algorithm. Plans were compared according to dose-volume histogram analysis in terms of planning target volume homogeneity and conformity indices (HI and CI) as well as organ at risk dose and volume parameters. Results BMS-IMRT had advantages over IMRT in terms of CI, but was equivalent to the latter in HI. V5, V10, V20, V30, and V40 of pelvic bone marrow in BMS-IMRT decreased by 0.06%, 17.33%, 22.19%, 13.85%, and 16.46%, respectively, compared with IMRT. Except for V30 of the small bowel and V30 and V40 of the bladder, no statistically significant differences were found between BMS-IMRT and IMRT in the small bowel, bladder, and rectum. Conclusion For cervical cancer patients receiving tomotherapy-based radiotherapy after hysterectomy, BMS-IMRT reduced pelvic bone marrow volume receiving low-dose radiation, and it may be conducive to preventing acute hematologic toxicity.
    Type of Medium: Online Resource
    ISSN: 2095-9621
    URL: Article
    DOI: 10.1007/s10330-014-1434-9
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2015
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  • 4
    Online Resource
    Online Resource
    Comparison of the effects of two types of multileaf collimators on tumor control probability in radiotherapy for breast cancer after conservative surgery based on the EUD model ⁎
    Ovid Technologies (Wolters Kluwer Health) ; 2017
    In:  Oncology and Translational Medicine Vol. 3, No. 2 ( 2017-04), p. 77-81
    Details
    In: Oncology and Translational Medicine, Ovid Technologies (Wolters Kluwer Health), Vol. 3, No. 2 ( 2017-04), p. 77-81
    Abstract: To compute and compare the tumor control probability (TCP) of volumetric modulated arc therapy (VMAT) for breast cancer after conservative surgery based on two types of multileaf collimator (MLC) through a retrospective planning study. Methods For a group of 9 patients diagnosed with left breast cancer, VMAT plan based on Agility MLC and beam modulator (BM) MLC were designed. The prescription dose was 50 Gy covering at least 95% of the planning target volume, 2 Gy per fraction. TCPs were calculated according to dose-volume histogram (DVH) analysis. Results The TCP of the BM VMAT plan was slightly higher than that of the Agility VMAT plan (94.61% vs 94.23%) but was inferior with respect to delivery efficiency; the delivery time was reduced for Agility VMAT plan by 35% compared to BM VMAT plan. Conclusion For breast cancer radiation therapy after conservative surgery, BM VMAT plans provide slightly higher TCP while the delivery of Agility VMAT plans is significantly faster than the BM VMAT plans.
    Type of Medium: Online Resource
    ISSN: 2095-9621
    URL: Article
    DOI: 10.1007/s10330-017-0218-8
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2017
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