In:
Cancer Science, Wiley, Vol. 109, No. 12 ( 2018-12), p. 4033-4044
Abstract:
Long noncoding RNAs (lnc RNA ) are reported to be potential cancer biomarkers. This study aims to find new lnc RNA biomarker relevant to lung adenocarcinoma. Gene expression profile and clinical data of lung adenocarcinoma and lung squamous cell carcinoma patients were downloaded from the UCSC Xena database. These data were analyzed to identify potential lnc RNA prognostic biomarkers, and the candidate lnc RNA s were analyzed and verified with association analysis, meta‐analysis, survival analysis, gene ontology analysis, gene set enrichment analysis, and other statistical methods. A group of 5 lnc RNA s was identified from the 1965 differentially expressed (fold‐change 〉 2) genes. Four of these 5 lnc RNA s were expressed at a lower level in lung adenocarcinoma tissues and the other one at a higher level ( P 〈 .0001). A risk score model was constructed using a linear combination of the expression levels of these lnc RNA s. High‐risk patients showed poorer overall survival (hazard ratio [ HR ] = 2.14; 95% confidence interval [ CI ], 1.67‐3.06, P 〈 .0001), disease‐free survival ( HR = 1.84; 95% CI , 1.26‐2.35, P = .0007), and recurrence‐free survival ( HR = 1.51; 95% CI , 1.02‐2.40, P = .04). The 5‐fold cross‐validation and subsequent meta‐analysis further verified that patients in the low‐risk group had better survival (95% CI , 0.74‐1.79, Z = 4.72, P 〈 .00001). Furthermore, both univariate and multivariate Cox regression analyses revealed that the prognostic value of these 5 lnc RNA s was independent of other clinical prognostic factors. Further analysis indicated that these 5 lnc RNA s might be associated with tumor metastasis. Taken together, our study suggests new prognostic lnc RNA biomarkers for lung adenocarcinoma.
Type of Medium:
Online Resource
ISSN:
1347-9032
,
1349-7006
DOI:
10.1111/cas.2018.109.issue-12
Language:
English
Publisher:
Wiley
Publication Date:
2018
detail.hit.zdb_id:
2115647-5
detail.hit.zdb_id:
2111204-6
Permalink