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  • MDPI AG  (24)
  • Liu, Lan  (24)
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  • MDPI AG  (24)
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  • 1
    Online Resource
    Online Resource
    Soil Phosphorus Availability Controls Deterministic and Stochastic Processes of Soil Microbial Community along an Elevational Gradient in Subtropical Forests
    MDPI AG ; 2023
    In:  Forests Vol. 14, No. 7 ( 2023-07-18), p. 1475-
    Details
    In: Forests, MDPI AG, Vol. 14, No. 7 ( 2023-07-18), p. 1475-
    Abstract: Revealing the assembly mechanisms of the soil microbial community, which is crucial to comprehend microbial biodiversity, is a central focus in ecology. The distribution patterns of microbial elevational diversity have been extensively studied, but their assembly processes and drivers remain unclear. Therefore, it is essential to unravel the relationship between the deterministic and stochastic processes of the microbial community assembly and elevational gradients. Here, our study built upon previous physicochemical analyses of soil samples collected along an elevational gradient (900–1500 m) in Daiyun mountain, a subtropical forest located in southeastern China. Using the phylogenetic-bin-based null model analysis (icamp) and multiple regression on matrices approach, we explored the major drivers that influence the assembly processes of soil bacterial and fungal community across elevations. The results showed that: (1) bacterial rare taxa exhibited a broad habitat niche breadth along the elevational gradient; (2) homogeneous selection and homogenizing dispersal proved to be the most important assembly processes for the bacterial and fungal community; (3) soil phosphorus availability mediated the relative importance of deterministic and stochastic processes in the soil microbial community. Notably, the relative abundance of dominant microbial taxa controlled by homogeneous selection and homogenizing dispersal increased with increasing soil phosphorus availability. Collectively, the assembly processes of microbial elevational communities of the subtropical mountains in China can be explained to some extent by variations in the soil phosphorus availability. This conclusion provides valuable insights into the prediction of soil microbial diversity and phosphorus nutrient cycling in subtropical montane forests.
    Type of Medium: Online Resource
    ISSN: 1999-4907
    URL: Article
    DOI: 10.3390/f14071475
    Language: English
    Publisher: MDPI AG
    Publication Date: 2023
    detail.hit.zdb_id: 2527081-3
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  • 2
    Online Resource
    Online Resource
    Heterologous Expression of Ilicicolin H Biosynthetic Gene Cluster and Production of a New Potent Antifungal Reagent, Ilicicolin J
    MDPI AG ; 2019
    In:  Molecules Vol. 24, No. 12 ( 2019-06-18), p. 2267-
    Details
    In: Molecules, MDPI AG, Vol. 24, No. 12 ( 2019-06-18), p. 2267-
    Abstract: Ilicicolin H is a broad-spectrum antifungal agent targeting mitochondrial cytochrome bc1 reductase. Unfortunately, ilicicolin H shows reduced activities in vivo. Here, we report our effort on the identification of ilicicolin H biosynthetic gene cluster (BGC) by genomic sequencing a producing strain, Neonectria sp. DH2, and its heterologous production in Aspergillus nidulans. In addition, a shunt product with similar antifungal activities, ilicicolin J, was uncovered. This effort would provide a base for future combinatorial biosynthesis of ilicicolin H analogues. Bioinformatics analysis suggests that the backbone of ilicicolin H is assembled by a polyketide-nonribosomal peptide synthethase (IliA), and then offloaded with a tetramic acid moiety. Similar to tenellin biosynthesis, the tetramic acid is then converted to pyridone by a putative P450, IliC. The decalin portion is most possibly constructed by a S-adenosyl-l-methionine (SAM)-dependent Diels-Alderase (IliD).
    Type of Medium: Online Resource
    ISSN: 1420-3049
    URL: Article
    DOI: 10.3390/molecules24122267
    Language: English
    Publisher: MDPI AG
    Publication Date: 2019
    detail.hit.zdb_id: 2008644-1
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  • 3
    Online Resource
    Online Resource
    Penicamide A, A Unique N,N′-Ketal Quinazolinone Alkaloid from Ascidian-Derived Fungus Penicillium sp. 4829
    MDPI AG ; 2019
    In:  Marine Drugs Vol. 17, No. 9 ( 2019-09-05), p. 522-
    Details
    In: Marine Drugs, MDPI AG, Vol. 17, No. 9 ( 2019-09-05), p. 522-
    Abstract: Previously unreported N,N′-ketal quinazolinone enantiomers [(−)-1 and (+)-1] and a new biogenetically related compound (2), along with six known compounds, 2-pyrovoylaminobenzamide (3), N-(2-hydroxypropanoyl)-2 amino benzoic acid amide (4), pseurotin A (5), niacinamide (6), citreohybridonol (7), citreohybridone C (8) were isolated from the ascidian-derived fungus Penicillium sp. 4829 in wheat solid-substrate medium culture. Their structures were elucidated by a combination of spectroscopic analyses (1D and 2D NMR and Electron Circular Dichroism data) and X-ray crystallography. The enantiomeric pair of 1 is the first example of naturally occurring N,N′-ketal quinazolinone possessing a unique tetracyclic system having 4-quinazolinone fused with tetrahydroisoquinoline moiety. The enantiomeric mixtures of 1 displayed an inhibitory effect on NO production in lipopolysaccharide-activated RAW264.7 cells, while the optically pure (–)-1 showed better inhibitory effect than (+)-1.
    Type of Medium: Online Resource
    ISSN: 1660-3397
    URL: Article
    DOI: 10.3390/md17090522
    Language: English
    Publisher: MDPI AG
    Publication Date: 2019
    detail.hit.zdb_id: 2175190-0
    SSG: 15,3
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  • 4
    Online Resource
    Online Resource
    Genome Mining of α-Pyrone Natural Products from Ascidian-Derived Fungus Amphichordafelina SYSU-MS7908
    MDPI AG ; 2022
    In:  Marine Drugs Vol. 20, No. 5 ( 2022-04-27), p. 294-
    Details
    In: Marine Drugs, MDPI AG, Vol. 20, No. 5 ( 2022-04-27), p. 294-
    Abstract: Culturing ascidian-derived fungus Amphichorda felina SYSU-MS7908 under standard laboratory conditions mainly yielded meroterpenoid, and nonribosomal peptide-type natural products. We sequenced the genome of Amphichorda felina SYSU-MS7908 and found 56 biosynthetic gene clusters (BGCs) after bioinformatics analysis, suggesting that the majority of those BGCSs are silent. Here we report our genome mining effort on one cryptic BGC by heterologous expression in Aspergillus oryzae NSAR1, and the identification of two new α-pyrone derivatives, amphichopyrone A (1) and B (2), along with a known compound, udagawanone A (3). Anti-inflammatory activities were performed, and amphichopyrone A (1) and B (2) displayed potent anti-inflammatory activity by inhibiting nitric oxide (NO) production in RAW264.7 cells with IC50 values 18.09 ± 4.83 and 7.18 ± 0.93 μM, respectively.
    Type of Medium: Online Resource
    ISSN: 1660-3397
    URL: Article
    DOI: 10.3390/md20050294
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2175190-0
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  • 5
    Online Resource
    Online Resource
    Studies on the Synthesis of Derivatives of Marine-Derived Bostrycin and Their Structure-Activity Relationship against Tumor Cells
    MDPI AG ; 2012
    In:  Marine Drugs Vol. 10, No. 12 ( 2012-04-24), p. 932-952
    Details
    In: Marine Drugs, MDPI AG, Vol. 10, No. 12 ( 2012-04-24), p. 932-952
    Type of Medium: Online Resource
    ISSN: 1660-3397
    URL: Article
    DOI: 10.3390/md10040932
    Language: English
    Publisher: MDPI AG
    Publication Date: 2012
    detail.hit.zdb_id: 2175190-0
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  • 6
    Online Resource
    Online Resource
    Anti-Inflammatory Cembrane-Type Diterpenoids and Prostaglandins from Soft Coral Lobophytum sarcophytoides
    MDPI AG ; 2019
    In:  Marine Drugs Vol. 17, No. 8 ( 2019-08-19), p. 481-
    Details
    In: Marine Drugs, MDPI AG, Vol. 17, No. 8 ( 2019-08-19), p. 481-
    Abstract: Two new cembrane-type diterpenoids, lobophytins A (1) and B (3), and four new prostaglandins, (5E)-PGB2 (10), (5E)-13,14-dihydro-PGB2 (11), 13,14-dihydro-PGB2 (12) and 13,14-dihydro-PGB2-Me (13), together with ten known compounds were isolated from the soft coral Lobophytum sarcophytoides. The structures of these new secondary metabolites were identified by high resolution mass spectrometry (HR-ESIMS), nuclear magnetic resonance (NMR) and electron circular dichroism (ECD) analyses, as well as the modified Mosher’s method. Compounds 6, 7, 9, 10, 12, 13, 15 and 16 showed potential anti-inflammatory activity by inhibiting the production of nitric oxide (NO) in RAW264.7 cells that were activated by lipopolysaccharide, with IC50 values ranging from 7.1 to 32.1 μM and were better than the positive control indomethacin, IC50 = 39.8 μM.
    Type of Medium: Online Resource
    ISSN: 1660-3397
    URL: Article
    DOI: 10.3390/md17080481
    Language: English
    Publisher: MDPI AG
    Publication Date: 2019
    detail.hit.zdb_id: 2175190-0
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  • 7
    Online Resource
    Online Resource
    Antimicrobial Activities of Sponge-Derived Microorganisms from Coastal Waters of Central Vietnam
    MDPI AG ; 2020
    In:  Journal of Marine Science and Engineering Vol. 8, No. 8 ( 2020-08-08), p. 594-
    Details
    In: Journal of Marine Science and Engineering, MDPI AG, Vol. 8, No. 8 ( 2020-08-08), p. 594-
    Abstract: Bacteria associated with invertebrates are considered as good sources for biologically active compounds. Sponge-derived bacteria were screened for antimicrobial activities, the presence of the cluster genes of polyketide synthases (PKSs) and non-ribosomal peptide synthetases (NRPSs), and through a colony picking method. Crude extracts of broth cultures were tested for microbial inhibition. Eleven out of 25 isolated strains showed inhibition of at least one of eight tested indicator microorganisms. Antimicrobial activities were observed in the strains coded HM5, HM6, and HM9 with the presence of NRPS and PKSII genes, whereas the isolate HM21 held both NRPS and PKSII and inhibited only the growth of Bacillus subtilis by the well diffusion method and only inhibited Serratia marcescens by the colony picking method. Two isolates, HM5 and HM6, belonged to the species of Bacillus. Interestingly, the isolate HM9 was nearest to Streptomyces mexicanusT NBRC100915 (GenBank accession number AB249966) with 94% sequence similarity. This potent strain HM9 could possibly be considered as a new species and a good source for bioactive compound discovery. Some isolates showed NRPS/PKS genes but did not exhibit antimicrobial activity. Thus, we suggested that both molecular and traditional methods should be conducted for the screening of antimicrobial producers.
    Type of Medium: Online Resource
    ISSN: 2077-1312
    URL: Article
    DOI: 10.3390/jmse8080594
    Language: English
    Publisher: MDPI AG
    Publication Date: 2020
    detail.hit.zdb_id: 2738390-8
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  • 8
    Online Resource
    Online Resource
    Antiplatelet and Antithrombotic Effects of Isaridin E Isolated from the Marine-Derived Fungus via Downregulating the PI3K/Akt Signaling Pathway
    MDPI AG ; 2021
    In:  Marine Drugs Vol. 20, No. 1 ( 2021-12-24), p. 23-
    Details
    In: Marine Drugs, MDPI AG, Vol. 20, No. 1 ( 2021-12-24), p. 23-
    Abstract: Isaridin E, a cyclodepsipeptide isolated from the marine-derived fungus Amphichorda felina (syn. Beauveria felina) SYSU-MS7908, has been demonstrated to possess anti-inflammatory and insecticidal activities. Here, we first found that isaridin E concentration-dependently inhibited ADP-induced platelet aggregation, activation, and secretion in vitro, but did not affect collagen- or thrombin-induced platelet aggregation. Furthermore, isaridin E dose-dependently reduced thrombosis formation in an FeCl3-induced mouse carotid model without increasing the bleeding time. Mechanistically, isaridin E significantly decreased the ADP-mediated phosphorylation of PI3K and Akt. In conclusion, these results suggest that isaridin E exerts potent antithrombotic effects in vivo without increasing the risk of bleeding, which may be due to its important role in inhibiting ADP-induced platelet activation, secretion and aggregation via the PI3K/Akt pathways.
    Type of Medium: Online Resource
    ISSN: 1660-3397
    URL: Article
    DOI: 10.3390/md20010023
    Language: English
    Publisher: MDPI AG
    Publication Date: 2021
    detail.hit.zdb_id: 2175190-0
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  • 9
    Online Resource
    Online Resource
    Russian Doll-like 3d–4f Cluster Wheels with Slow Relaxation of Magnetization
    MDPI AG ; 2023
    In:  Molecules Vol. 28, No. 15 ( 2023-08-06), p. 5906-
    Details
    In: Molecules, MDPI AG, Vol. 28, No. 15 ( 2023-08-06), p. 5906-
    Abstract: The solvothermal reactions of LnCl3·6H2O and MCl2·6H2O (M = Co, Ni) with 2,2′-diphenol (H2L1) and 5,7-dichloro-8-hydroxyquinoline (HL2) gave three 3d–4f heterometallic wheel-like nano-clusters [Ln7M6(L1)6(L2)6(µ3-OH)6(OCH3)6Cl(CH3CN)6]Cl2·xH2O (Ln = Dy, M = Co, x = 3 for 1; Ln = Dy, M = Ni, x = 0 for 2; Ln = Tb, M = Ni, x = 0 for 3) with similar cluster structure. The innermost Ln(III) ion is encapsulated in a planar Ln6 ring which is further embedded in a chair-conformation M6 ring, constructing a Russian doll-like 3d–4f cluster wheel Ln(III)⸦Ln6⸦M6. 2 and 3 show obvious slow magnetic relaxation behavior with negligible opening of the magnetic hysteresis loop. Such a Russian doll-like 3d–4f cluster wheel with the lanthanide disc isolated by transition metallo-ring is rarely reported.
    Type of Medium: Online Resource
    ISSN: 1420-3049
    URL: Article
    DOI: 10.3390/molecules28155906
    Language: English
    Publisher: MDPI AG
    Publication Date: 2023
    detail.hit.zdb_id: 2008644-1
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  • 10
    Online Resource
    Online Resource
    Immobilized and Free Cells of Geotrichum candidum for Asymmetric Reduction of Ketones: Stability and Recyclability
    MDPI AG ; 2018
    In:  Molecules Vol. 23, No. 9 ( 2018-08-27), p. 2144-
    Details
    In: Molecules, MDPI AG, Vol. 23, No. 9 ( 2018-08-27), p. 2144-
    Abstract: Marine-derived fungus Geotrichum candidum AS 2.361 was previously reported by our group as an active strain for the enantioselective reduction of ketones. Although some other Geotrichum strains were also found from the terrestrial sources, information on their stability and reusability is scarce. Herein, the stabilities—in terms of pH tolerance, thermostability, and storage stability, and reusability—of G. candidum AS 2.361 were described for the asymmetric reduction of a series of aromatic ketones. Two differently immobilized cells (agar immobilization and calcium alginate immobilization) as well as free cells were prepared. For three substrates (1-(3-bromophenyl) ethan-1-one (1b), 1-(2-chlorophenyl) ethan-1-one (1d), and acetophenone (1g)) immobilized cells on agar showed a great improvement in the bioreduction activities compared to the free cells, increasing yields up to 97% with ee values of 99%. Cells immobilized on agar/calcium alginate could maintain more than 90% of the original activities within the assayed pH ranges of 3.5–11, while free cells were highly sensitive to alkaline and acidic conditions. Concerning thermostability, immobilized cells on agar kept 99% of their original activities after incubation at 60 °C for 1 h, while almost no activity was detected for the free cells under the same condition. Immobilized cells were stable at 4 °C for 80 days without any activity loss, while free cells started to decrease the activity after storage at 4 °C for six days. The immobilized cells retained almost 99% activity after four reuse cycles, while free cells lost almost all the activities at on the third cycle.
    Type of Medium: Online Resource
    ISSN: 1420-3049
    URL: Article
    DOI: 10.3390/molecules23092144
    Language: English
    Publisher: MDPI AG
    Publication Date: 2018
    detail.hit.zdb_id: 2008644-1
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