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  • Wiley  (11)
  • Liu, Jun  (11)
  • Medicine  (11)
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  • Wiley  (11)
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  • Medicine  (11)
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  • 1
    Online Resource
    Online Resource
    Impaired Ocular Tracking and Cortical Atrophy in Idiopathic Rapid Eye Movement Sleep Behavior Disorder
    Wiley ; 2022
    In:  Movement Disorders Vol. 37, No. 5 ( 2022-05), p. 972-982
    Details
    In: Movement Disorders, Wiley, Vol. 37, No. 5 ( 2022-05), p. 972-982
    Abstract: Idiopathic rapid eye movement sleep behavior disorder (iRBD) is a prodromal stage of synucleinopathies. Patients with synucleinopathies frequently display eye movement abnormalities. However, whether patients with iRBD have eye movement abnormalities remains unknown. Objective The aim of this study was to assess eye movement abnormalities and related gray matter alterations and explore whether such abnormalities can serve as biomarkers to indicate phenoconversion to synucleinopathies in iRBD. Methods Forty patients with iRBD with early disease progression and 35 healthy control subjects participated in a 15‐minute ocular‐tracking task that evaluated their control of eye movement abilities. They also underwent clinical assessments for olfactory function, nonmotor symptoms, and autonomic symptoms, all of which are biomarkers to predict phenoconversion to synucleinopathies in iRBD. A subgroup of the participants (20 patients with iRBD and 20 healthy control subjects) also participated in structural magnetic resonance imaging. Results The ocular‐tracking ability in patients with iRBD was inferior to that of healthy control subjects in two aspects: pursuit initiation and steady‐state tracking. Cortical thinning in the right visual area V4 in patients with iRBD is coupled with impaired pursuit initiation. Furthermore, prolonged pursuit initiation in patients with iRBD exhibits a trend of correlation with olfactory loss, the earliest biomarker that develops prior to other prodromal biomarkers. Conclusions We found ocular‐tracking abnormalities in patients with iRBD even early in their disease progression that have not been reported before. These abnormalities are coupled with atrophy of brain areas involved in the perception of object motion and might indicate phenoconversion to synucleinopathies in iRBD. © 2022 International Parkinson and Movement Disorder Society
    Type of Medium: Online Resource
    ISSN: 0885-3185 , 1531-8257
    URL: Issue
    URL: Article
    DOI: 10.1002/mds.v37.5
    DOI: 10.1002/mds.28931
    RVK:
    XA 10000
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2041249-6
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  • 2
    Online Resource
    Online Resource
    The B cell novel protein 1 (BCNP1) regulates BCR signaling and B cell apoptosis
    Wiley ; 2019
    In:  European Journal of Immunology Vol. 49, No. 6 ( 2019-06), p. 911-917
    Details
    In: European Journal of Immunology, Wiley, Vol. 49, No. 6 ( 2019-06), p. 911-917
    Abstract: The BCR plays a central role in B cell development, survival, activation, and differentiation. We have identified the B cell novel protein 1 (BCNP1) as a new regulator of BCR signaling. BCNP1 contains a pleckstrin homology domain, three proline‐rich motifs, and a potential SH2 binding site, and is predominantly expressed by B cells. We found that BCNP1 overexpression in WEHI231 immature B cells potentiated α‐IgM‐induced apoptosis. Conversely, BCNP1‐deficient WEHI231 cells, generated by CRISPR‐Cas9‐mediated genome editing, exhibited reduced apoptosis after BCR crosslinking. Biochemical analyses revealed that BCNP1 physically interacted with the B cell linker protein (BLNK), Grb2, and PLCγ2. Moreover, absence of BCNP1 resulted in accelerated dephosphorylation of BLNK, reduced phosphorylation of SYK and PLCγ2, and decreased Ca 2+ influx after BCR crosslinking. These results demonstrate that BCNP1 promotes BCR signaling by modulating the phosphorylation of BLNK, SYK, and PLCγ2.
    Type of Medium: Online Resource
    ISSN: 0014-2980 , 1521-4141
    URL: Issue
    URL: Article
    DOI: 10.1002/eji.v49.6
    DOI: 10.1002/eji.201847985
    RVK:
    XA 10000
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 1491907-2
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  • 3
    Online Resource
    Online Resource
    Increased Free Water in the Putamen in Idiopathic REM Sleep Behavior Disorder
    Wiley ; 2023
    In:  Movement Disorders Vol. 38, No. 9 ( 2023-09), p. 1645-1654
    Details
    In: Movement Disorders, Wiley, Vol. 38, No. 9 ( 2023-09), p. 1645-1654
    Abstract: It has been suggested that the loss of nigrostriatal dopaminergic axon terminals occurs before the loss of dopaminergic neurons in the substantia nigra (SN) in Parkinson's disease (PD). This study aimed to use free‐water imaging to evaluate microstructural changes in the dorsoposterior putamen (DPP) of idiopathic rapid eye movement (REM) sleep behavior disorder (iRBD) patients, which is considered a prodromal stage of synucleinopathies. Methods Free water values in the DPP, dorsoanterior putamen (DAP), and posterior SN were compared between the healthy controls (n = 48), iRBD (n = 43) and PD (n = 47) patients. In iRBD patients, the relationships between baseline and longitudinal free water values and clinical manifestations or dopamine transporter (DAT) striatal binding ratio (SBR) were analyzed. Results Free water values were significantly higher in the DPP and posterior substantia nigra (pSN), but not in the DAP, in the iRBD and PD groups than in controls. In iRBD patients, free water values in the DPP were progressively increased and correlated with the progression of clinical manifestations and the striatal DAT SBR. Baseline free water in the DPP was negatively correlated with striatal DAT SBR and hyposmia and positively correlated with motor deficits. Conclusions This study demonstrates that free water values in the DPP are increased cross‐sectionally and longitudinally and associated with clinical manifestations and the function of the dopaminergic system in the prodromal stage of synucleinopathies. Our findings indicate that free‐water imaging of the DPP has the potential to be a valid marker of early diagnosis and progression of synucleinopathies. © 2023 International Parkinson and Movement Disorder Society.
    Type of Medium: Online Resource
    ISSN: 0885-3185 , 1531-8257
    URL: Issue
    URL: Article
    DOI: 10.1002/mds.v38.9
    DOI: 10.1002/mds.29499
    RVK:
    XA 10000
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2041249-6
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  • 4
    Online Resource
    Online Resource
    LIMK2 acts as an oncogene in bladder cancer and its functional SNP in the microRNA‐135a binding site affects bladder cancer risk
    Wiley ; 2019
    In:  International Journal of Cancer Vol. 144, No. 6 ( 2019-03-15), p. 1345-1355
    Details
    In: International Journal of Cancer, Wiley, Vol. 144, No. 6 ( 2019-03-15), p. 1345-1355
    Abstract: What's new? Genetic variations in microRNA (miRNA)‐binding regions are suspected to influence tumorigenesis. In this study, in tissues from bladder cancer (BC) patients, the single nucleotide polymorphism rs2073859 (G‐to‐A allele) in the 3’‐UTR miRNA‐135a‐binding site of the oncogene LIM kinase 2 (LIMK2) was associated with gene overexpression and higher clinical grade. A high frequency of rs2073859 A genotypes was detected in BC tissues. In BC cells and mice, LIMK2 overexpression promoted cell proliferation, migration, and invasion and accelerated BC tumor growth. The findings suggest that LIMK2 normally is downregulated by miRNA‐135a and becomes tumorigenic following miRNA‐135a disruption by rs2073859 variant A.
    Type of Medium: Online Resource
    ISSN: 0020-7136 , 1097-0215
    URL: Issue
    URL: Article
    DOI: 10.1002/ijc.v144.6
    DOI: 10.1002/ijc.31757
    RVK:
    XA 10000
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 218257-9
    detail.hit.zdb_id: 1474822-8
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  • 5
    Online Resource
    Online Resource
    Preconception thyroid‐stimulating hormone levels and adverse pregnancy outcomes
    Wiley ; 2022
    In:  Clinical Endocrinology Vol. 97, No. 3 ( 2022-09), p. 339-346
    Details
    In: Clinical Endocrinology, Wiley, Vol. 97, No. 3 ( 2022-09), p. 339-346
    Abstract: Evidence for the association between subclinical thyroid dysfunction before conception and its pregnancy outcomes is inconsistent. Thus, we evaluated the relationship between preconception thyroid‐stimulating hormone (TSH) levels and adverse pregnancy outcomes. Design Retrospective cohort study. Methods A total of 50,217 women without prior thyroid disease who became pregnant within 1 year after undertaking a routine TSH test in the Chongqing Municipality of China (2010–2016) were studied. Restricted cubic spline regression and logistic regression were used to estimate the association between preconception TSH levels and pregnancy outcomes. The main outcomes were individual and composite adverse pregnancy outcomes (CAPOs) comprising pregnancy loss, small for gestational age, large for gestational age, and preterm birth. Results Incidence of CAPO was 24.19%. Increased preconception TSH level was positively associated with CAPO (odds ratio [OR]/SD: 1.04, 95% confidence interval [CI] : 1.01–1.07) when TSH was ≥2.1 mIU/L, positively associated with pregnancy loss (OR/SD: 1.06, 95% CI: 1.01–1.12) when TSH was 〈 2.1 mIU/L, negatively and positively associated with preterm delivery when TSH levels were 〈 1.3 mIU/L (OR/SD: 0.90, 95% CI: 0.83–0.97) and 〉 3.0 mIU/L (OR/SD: 1.08, 95% CI: 1.00–1.17), respectively. Women with subclinical hypothyroidism before conception were at a higher risk for CAPO (adjusted odds ratio [aOR]: 1.12, 95% CI: 1.04–1.22), while those with subclinical hyperthyroidism had a higher risk of preterm delivery (aOR: 1.31, 95% CI: 1.01–1.70). Conclusions Nonlinear associations were indicated between preconception TSH levels and pregnancy outcomes. Subclinical thyroid dysfunction before conception was associated with an increased risk of adverse pregnancy outcomes.
    Type of Medium: Online Resource
    ISSN: 0300-0664 , 1365-2265
    URL: Issue
    URL: Article
    DOI: 10.1111/cen.v97.3
    DOI: 10.1111/cen.14668
    RVK:
    XA 10000
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2004597-9
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  • 6
    Online Resource
    Online Resource
    Increased Free Water in the Substantia Nigra in Asymptomatic LRRK2 G2019S Mutation Carriers
    Wiley ; 2023
    In:  Movement Disorders Vol. 38, No. 1 ( 2023-01), p. 138-142
    Details
    In: Movement Disorders, Wiley, Vol. 38, No. 1 ( 2023-01), p. 138-142
    Abstract: The alteration of substantia nigra (SN) degeneration in populations at risk of Parkinson's disease (PD) is unclear. Objective We investigated free water (FW) values in the posterior SN (pSN) in asymptomatic LRRK2 G2019S mutation carriers. Methods We analyzed diffusion imaging data from 28 asymptomatic LRRK2 G2019S mutation carriers and 30 healthy controls (HCs), whereas 11 asymptomatic LRRK2 G2019S carriers and 11 HCs were followed up. FW values in the pSN were measured and compared between the groups. The relationship between longitudinal changes in FW in the pSN and dopamine transporter striatal binding ratio (SBR) was analyzed. Results FW values in the pSN were significantly elevated and kept increasing during follow‐up in asymptomatic LRRK2 G2019S carriers. There was a negative correlation between FW changes in the left pSN and SBR changes in the left putamen. Conclusion FW in the pSN has the potential to be a progression imaging marker of early dopaminergic degeneration in the population at risk of PD. © 2022 International Parkinson and Movement Disorder Society.
    Type of Medium: Online Resource
    ISSN: 0885-3185 , 1531-8257
    URL: Issue
    URL: Article
    DOI: 10.1002/mds.v38.1
    DOI: 10.1002/mds.29253
    RVK:
    XA 10000
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2041249-6
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  • 7
    Online Resource
    Online Resource
    Cross‐talk Between Histone and DNA Methylation Mediates Bone Loss in Hind Limb Unloading
    Wiley ; 2021
    In:  Journal of Bone and Mineral Research Vol. 36, No. 5 ( 2021-05), p. 956-967
    Details
    In: Journal of Bone and Mineral Research, Wiley, Vol. 36, No. 5 ( 2021-05), p. 956-967
    Abstract: Bone loss induced by mechanical unloading is a common skeletal disease, but the precise mechanism remains unclear. The current study investigated the role of histone methylation, a key epigenetic marker, and its cross‐talk with DNA methylation in bone loss induced by mechanical unloading. The expression of G9a, ubiquitin‐like with PHD and ring finger domains 1 (UHRF1), and DNA methylation transferase 1 (DNMT1) were increased in hind limb unloading (HLU) rats. This was accompanied by an increased level of histone H3 lysine 9 (H3K9) di‐/tri‐methylation at lncH19 promoter. Then, alteration of G9a, DNMT1, or UHRF1 expression significantly affected lncH19 level and osteogenic activity in UMR106 cells. Osteogenic gene expression and matrix mineralization were robustly promoted after simultaneous knockdown of G9a, DNMT1, and UHRF1. Furthermore, physical interactions of lncH19 promoter with G9a and DNMT1, as well as direct interactions among DNMT1, G9a, and UHRF1 were detected. Importantly, overexpression of DNMT1, G9a, or UHRF1, respectively, resulted in enrichment of H3K9me2/me3 and 5‐methylcytosine at lncH19 promoter. Finally, in vivo rescue experiments indicated that knockdown of DNMT1, G9a, or UHRF1 significantly relieved bone loss in HLU rats. In conclusion, our research demonstrated the critical role of H3K9 methylation and its cross‐talk with DNA methylation in regulating lncH19 expression and bone loss in HLU rats. Combined targeting of DNMT1, G9a, and UHRF1 could be a promising strategy for the treatment of bone loss induced by mechanical unloading. © 2021 American Society for Bone and Mineral Research (ASBMR).
    Type of Medium: Online Resource
    ISSN: 0884-0431 , 1523-4681
    URL: Issue
    URL: Article
    DOI: 10.1002/jbmr.v36.5
    DOI: 10.1002/jbmr.4253
    RVK:
    XA 52230
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2008867-X
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  • 8
    Online Resource
    Online Resource
    Arid1a promotes thymocyte development through β‐selection‐dependent and β‐selection‐independent mechanisms
    Wiley ; 2022
    In:  Immunology Vol. 165, No. 4 ( 2022-04), p. 402-413
    Details
    In: Immunology, Wiley, Vol. 165, No. 4 ( 2022-04), p. 402-413
    Abstract: Early T‐cell development from CD4 −  CD8 − double‐negative (DN) stage to CD4 +  CD8 + double‐positive (DP) stage in the thymus is regulated through multiple steps involving a batch of sequentially expressed factors. Our preliminary data and a recent report showed that AT‐rich interaction domain 1A (Arid1a) is required for the transition from DN to DP stages, but the mechanism is not fully understood. In this study, we consolidated that conditional deletion of Arid1a in T‐cell lineage intrinsically caused developmental blocks from DN3 to DN4 stages, as well as from DN4 to DP stages using both in vivo adoptive T‐cell transfer model and in vitro culture system. The expression of intracellular TCRβ is significantly decreased in Arid1a‐deficient DN4 cells compared with WT cells. OT1 transgenic TCR can rescue the defect in the transition from DN3 to DN4 stages, but not from DN to DP stages. Furthermore, we observed a comparable or stronger proliferation capacity accompanied by a significant increase in cell death in Arid1a −/− DP cells compared with that in WT controls. RNA‐Seq analysis shows a significant enrichment of apoptotic pathway within differentially expressed genes between Arid1a −/− and WT DP cells, including the upregulation of Bim , Casp3 and Trp53 and the downregulation of Rorc , Bcl ‐ XL and Mcl1 . Therefore, our study reveals a novel mechanism that Arid1a controls early T‐cell development by maintaining intracellular TCRβ expression‐mediated β‐selection and activating parallel cell survival pathways.
    Type of Medium: Online Resource
    ISSN: 0019-2805 , 1365-2567
    URL: Issue
    URL: Article
    DOI: 10.1111/imm.v165.4
    DOI: 10.1111/imm.13440
    RVK:
    XA 10000
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2006481-0
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  • 9
    Online Resource
    Online Resource
    Clinical efficacy of methylprednisolone and the combined use of lopinavir/ritonavir with arbidol in treatment of coronavirus disease 2019
    Wiley ; 2021
    In:  Journal of Medical Virology Vol. 93, No. 7 ( 2021-07), p. 4446-4453
    Details
    In: Journal of Medical Virology, Wiley, Vol. 93, No. 7 ( 2021-07), p. 4446-4453
    Abstract: This study aims to comparatively analyze the therapeutic efficacy upon multiple medication plans over lopinavir/ritonavir (LPV/r), arbidol (ARB), and methylprednisolone on patients with coronavirus disease 2019 (COVID‐19). Totally, 75 COVID‐19 patients admitted to The First Affiliated Hospital, Zhejiang University School of Medicine from January 22, 2020 to February 29, 2020 were recruited and grouped based on whether or not LPV/r and ARB were jointly used and whether or not methylprednisolone was used. Indexes including body temperature, time for nucleic acid negative conversion, hospital stays, and laboratory indexes were examined and compared. For all patients, there were no significant differences in the change of body temperature, the time for negative conversion, and hospital stays whether LPV/r and ARB were jointly used or not. While for severe and critically severe patients, methylprednisolone noticeably reduced the time for negative conversion. Meanwhile, the clinical efficacy was superior on patients receiving methylprednisolone within 3 days upon admission, and the duration of hospital stays was much shorter when methylprednisolone was given at a total dose of 0–400 mg than a higher dose of 〉 400 mg if all patients received a similar dose per day. Nonetheless, no significant changes across hepatic, renal, and myocardial function indexes were observed. LPV/r combined with ARB produced no noticeably better effect on COVID‐19 patients relative to the single‐agent treatment. Additionally, methylprednisolone was efficient in severe and critically severe cases, and superior efficacy could be realized upon its early, appropriate, and short‐term application.
    Type of Medium: Online Resource
    ISSN: 0146-6615 , 1096-9071
    URL: Issue
    URL: Article
    DOI: 10.1002/jmv.v93.7
    DOI: 10.1002/jmv.26798
    RVK:
    XA 10000
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 752392-0
    detail.hit.zdb_id: 1475090-9
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  • 10
    Online Resource
    Online Resource
    Gene silencing of MIR22 in acute lymphoblastic leukaemia involves histone modifications independent of promoter DNA methylation : Histone Modifications Silence MIR22 in ALL
    Wiley ; 2010
    In:  British Journal of Haematology Vol. 148, No. 1 ( 2010-01), p. 69-79
    Details
    In: British Journal of Haematology, Wiley, Vol. 148, No. 1 ( 2010-01), p. 69-79
    Type of Medium: Online Resource
    ISSN: 0007-1048 , 1365-2141
    URL: Issue
    URL: Journal
    URL: Article
    DOI: 10.1111/bjh.2009.148.issue-1
    DOI: 10.1111/(ISSN)1365-2141
    DOI: 10.1111/j.1365-2141.2009.07920.x
    RVK:
    XA 34100
    Language: English
    Publisher: Wiley
    Publication Date: 2010
    detail.hit.zdb_id: 1475751-5
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