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  • Wiley  (34)
  • Liu, Jiayi  (34)
  • 1
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    Online Resource
    Age‐related rhesus macaque models of COVID‐19
    Wiley ; 2020
    In:  Animal Models and Experimental Medicine Vol. 3, No. 1 ( 2020-03), p. 93-97
    Details
    In: Animal Models and Experimental Medicine, Wiley, Vol. 3, No. 1 ( 2020-03), p. 93-97
    Abstract: Since December 2019, an outbreak of the Corona Virus disease 2019 (COVID‐19) caused by severe acute respiratory syndrome coronavirus (SARS‐CoV‐2) in Wuhan, China, has become a public health emergency of international concern. The high fatality of aged cases caused by SARS‐CoV‐2 was a need to explore the possible age‐related phenomena with non‐human primate models. Methods Three 3‐5 years old and two 15 years old rhesus macaques were intratracheally infected with SARS‐CoV‐2, and then analyzed by clinical signs, viral replication, chest X‐ray, histopathological changes and immune response. Results Viral replication of nasopharyngeal swabs, anal swabs and lung in old monkeys was more active than that in young monkeys for 14 days after SARS‐CoV‐2 challenge. Monkeys developed typical interstitial pneumonia characterized by thickened alveolar septum accompanied with inflammation and edema, notably, old monkeys exhibited diffuse severe interstitial pneumonia. Viral antigens were detected mainly in alveolar epithelial cells and macrophages. Conclusion SARS‐CoV‐2 caused more severe interstitial pneumonia in old monkeys than that in young monkeys. Rhesus macaque models infected with SARS‐CoV‐2 provided insight into the pathogenic mechanism and facilitated the development of vaccines and therapeutics against SARS‐CoV‐2 infection.
    Type of Medium: Online Resource
    ISSN: 2576-2095 , 2576-2095
    URL: Article
    DOI: 10.1002/ame2.12108
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 3009615-7
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  • 2
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    miR ‐29a‐3p promotes migration and invasion in ameloblastoma via Wnt/β‐catenin signaling by targeting catenin beta interacting protein 1
    Wiley ; 2021
    In:  Head & Neck Vol. 43, No. 12 ( 2021-12), p. 3911-3921
    Details
    In: Head & Neck, Wiley, Vol. 43, No. 12 ( 2021-12), p. 3911-3921
    Abstract: Ameloblastoma (AB) is a common epithelial odontogenic tumor. The Wnt/β‐catenin pathway has been found to be related to AB invasion. Methods The alteration expression of microRNAs (miRNAs) and messenger RNAs (mRNAs) was performed by miRNA and mRNA microarray analysis and validated by quantitative real‐time polymerase chain reaction (RT‐PCR). The effects of miR‐29a‐3p on migration and invasion in AB cells were evaluated by a transwell assay. Bioinformatic prediction was conducted using the miRSystem and validated by quantitative RT‐PCR, western blot, and a luciferase reporter assay. Results miR‐29a‐3p was overexpressed in AB tissues, which promoted the migration and invasion of AB cells in vitro. Catenin beta interacting protein 1 (CTNNBIP1), a negative regulator of the Wnt/β‐catenin pathway, was predicted to be a target of miR‐29a‐3p. miR‐29a‐3p inhibited the expression of CTNNBIP1 and promoted the expression of the downstream molecules of the Wnt/β‐catenin pathway. Conclusions miR‐29a‐3p promoted migration and invasion in AB via Wnt/β‐catenin signaling by targeting CTNNBIP1.
    Type of Medium: Online Resource
    ISSN: 1043-3074 , 1097-0347
    URL: Issue
    URL: Article
    DOI: 10.1002/hed.v43.12
    DOI: 10.1002/hed.26888
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2001440-5
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  • 3
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    Effects on resting‐state EEG phase‐amplitude coupling in insomnia disorder patients following 1 Hz left dorsolateral prefrontal cortex rTMS
    Wiley ; 2023
    In:  Human Brain Mapping Vol. 44, No. 8 ( 2023-06), p. 3084-3093
    Details
    In: Human Brain Mapping, Wiley, Vol. 44, No. 8 ( 2023-06), p. 3084-3093
    Abstract: Despite burgeoning evidence for cortical hyperarousal in insomnia disorder, the existing results on electroencephalography spectral features are highly heterogeneous. Phase‐amplitude coupling, which refers to the modulation of the low‐frequency phase to a high‐frequency amplitude, is probably a more sensitive quantitative measure for characterizing abnormal neural oscillations and explaining the therapeutic effect of repetitive transcranial magnetic stimulation in the treatment of patients with insomnia disorder. Sixty insomnia disorder patients were randomly divided into the active and sham treatment groups to receive 4 weeks of repetitive transcranial magnetic stimulation treatment. Behavioral assessments, resting‐state electroencephalography recordings, and sleep polysomnography recordings were performed before and after repetitive transcranial magnetic stimulation treatment. Forty good sleeper controls underwent the same assessment. We demonstrated that phase‐amplitude coupling values in the frontal and temporal lobes were weaker in Insomnia disorder patients than in those with good sleeper controls at baseline and that phase‐amplitude coupling values near the intervention area were significantly enhanced after active repetitive transcranial magnetic stimulation treatment. Furthermore, the enhancement of phase‐amplitude coupling values was significantly correlated with the improvement of sleep quality. This study revealed the potential of phase‐amplitude coupling in assessing the severity of insomnia disorder and the efficacy of repetitive transcranial magnetic stimulation treatment, providing new insights on the abnormal physiological mechanisms and future treatments for insomnia disorder.
    Type of Medium: Online Resource
    ISSN: 1065-9471 , 1097-0193
    URL: Issue
    URL: Article
    DOI: 10.1002/hbm.v44.8
    DOI: 10.1002/hbm.26264
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 1492703-2
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  • 4
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    Handwriting Character Recognition Based on Conductor/Insulator‐Identifiable E‐Tattoo Proximity Sensors for Blinds
    Wiley ; 2024
    In:  Advanced Functional Materials Vol. 34, No. 1 ( 2024-01)
    Details
    In: Advanced Functional Materials, Wiley, Vol. 34, No. 1 ( 2024-01)
    Abstract: Easy and convenient reading for blinds is of great significance for lowering their learning, entertainment, and communication barrier, and improving their living quality. The general solution is to learn braille, far from satisfying the meet of the blinds’ daily learning and communication. Here, a new‐type conductor/insulator‐identifiable e‐tattoo proximity sensor is developed by simply depositing the circular interdigitated electrodes on organic semiconductor. The discriminable recognition toward conductors and insulators is realized only based on a single e‐tattoo device. The sensors not only enable recognition of the protruding characters like braille based on distance difference, but also enable recognition of the handwriting ink‐brush and pencil graphite characters based on the unique advantage of the sensors in distinguishing conduct and insulator. These results open a new route to realize the material category recognition, provide a user‐friendly way to help the visual impaired effectively reintegrate into society, and broaden the application field of proximity sensors.
    Type of Medium: Online Resource
    ISSN: 1616-301X , 1616-3028
    URL: Issue
    URL: Article
    DOI: 10.1002/adfm.v34.1
    DOI: 10.1002/adfm.202306704
    Language: English
    Publisher: Wiley
    Publication Date: 2024
    detail.hit.zdb_id: 2029061-5
    detail.hit.zdb_id: 2039420-2
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  • 5
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    Non‐alcoholic fatty liver disease and complications in type 1 and type 2 diabetes: A Mendelian randomization study
    Wiley ; 2023
    In:  Diabetes, Obesity and Metabolism Vol. 25, No. 2 ( 2023-02), p. 365-376
    Details
    In: Diabetes, Obesity and Metabolism, Wiley, Vol. 25, No. 2 ( 2023-02), p. 365-376
    Abstract: To investigate the potential causal relationship between non‐alcoholic fatty liver disease (NAFLD) and complications in type 1 diabetes (T1D) and type 2 diabetes (T2D). Materials and Methods Two‐sample Mendelian randomization (MR) analysis was conducted to appraise after controlling for the confounding factors. Genetic instrument variables for NAFLD surrogated by chronically elevated serum alanine transferase were derived from a recent genome‐wide association study. Diabetes‐related complications, including diabetic ketoacidosis, nephropathy and retinopathy, were included as outcomes. Four complementary MR methods were used to test reliability. Results Genetically instrumented NAFLD showed a suggestive causal association with ketoacidosis in T1D (odds ratio [OR]: 1.574; 95% confidence interval [CI] : 1.076, 2.302; P  = .019; false discovery rate [FDR] = 0.096) and a significant causal association with early‐stage kidney disease in T1D (OR: 1.249; 95% CI: 1.089, 1.432; P  = 1.457 × 10 −3 , FDR = 0.015). Sensitivity analysis indicated low heterogeneity, low pleiotropy and high reliability of the causal estimates. However, the MR analyses failed to show a causal association between NAFLD and T1D retinopathy, T2D ketoacidosis, nephropathy and retinopathy. Conclusions This study supports a causal effect of genetically driven chronic serum alanine aminotransferase‐associated NAFLD on early‐stage kidney disease in T1D and a suggestive causal effect on ketoacidosis in T1D. However, MR studies did not provide enough evidence to suggest that NAFLD independently increases the risk of retinopathy in T1D and of ketoacidosis, nephropathy and retinopathy in T2D.
    Type of Medium: Online Resource
    ISSN: 1462-8902 , 1463-1326
    URL: Issue
    URL: Article
    DOI: 10.1111/dom.v25.2
    DOI: 10.1111/dom.14877
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2004918-3
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  • 6
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    Study of three‐point bending behaviors of composite sandwich structure with re‐entrant honeycomb cores
    Wiley ; 2023
    In:  Polymer Composites Vol. 44, No. 1 ( 2023-01), p. 673-684
    Details
    In: Polymer Composites, Wiley, Vol. 44, No. 1 ( 2023-01), p. 673-684
    Abstract: The composite re‐entrant honeycomb structures were fabricated by hot pressing and bonding processes in this article. The bending responses of composite re‐entrant honeycomb structure under three‐point bending load were studied experimentally. The bending deformation, failure process and failure load were analyzed and discussed. The influence of wall thickness gradient form which were less reported on the bending behaviors of composite re‐entrant honeycomb structures was investigated. The gradient distributions included positive gradient, negative gradient and homogeneous structures. The experimental results indicated that the wall thickness gradient design influenced the bending failure modes of composite re‐entrant honeycomb structures, and the negative gradient honeycomb structure mainly exhibited the whole bending deformation under three‐point bending loading. The influence of the relative densities on the bending behaviors of composite re‐entrant honeycomb structures was also studied. The results of three‐point bending experiment showed that the bending failure load increased significantly with the increase of relative density.
    Type of Medium: Online Resource
    ISSN: 0272-8397 , 1548-0569
    URL: Issue
    URL: Article
    DOI: 10.1002/pc.v44.1
    DOI: 10.1002/pc.27128
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 1475935-4
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  • 7
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    The indentation responses of composite Y‐type cores sandwich structure under various temperatures
    Wiley ; 2022
    In:  Polymer Composites Vol. 43, No. 1 ( 2022-01), p. 533-542
    Details
    In: Polymer Composites, Wiley, Vol. 43, No. 1 ( 2022-01), p. 533-542
    Abstract: The influences of elevated and cryogenic temperature on the quasi‐static indentation responses and damage mechanism for composite Y‐type cores sandwich structure were studied by experiments in present paper. The quasi‐static indentation experiments were performed to explore the indentation performances for composite Y‐type cores sandwich structures under eight different temperature conditions. The influences of the testing environment temperature on the typical indentation force‐deformation curves, damage patterns and indentation failure load were investigated and analyzed. The experimental results demonstrated that the testing environment temperature made an important influence on the deformation mechanism, typical force‐deformation curves and failure load. Fiber fracture of the front panel was found when the testing environment temperature was below the glass transition temperature, while the fiber microbuckling of the front panel was also revealed when the testing environment temperature was above the glass transition temperature. The failure load increased with the decreasing of the testing environment temperature at cryogenic temperature. Nevertheless, at elevated temperature, the failure load decreased with the increasing of the testing environment temperature attributing to the weakening of the fiber‐matrix interface performances.
    Type of Medium: Online Resource
    ISSN: 0272-8397 , 1548-0569
    URL: Issue
    URL: Article
    DOI: 10.1002/pc.v43.1
    DOI: 10.1002/pc.26396
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 1475935-4
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  • 8
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    Boosting Activity and Stability of Electrodeposited Amorphous Ce‐Doped NiFe‐Based Catalyst for Electrochemical Water Oxidation
    Wiley ; 2022
    In:  Advanced Functional Materials Vol. 32, No. 35 ( 2022-08)
    Details
    In: Advanced Functional Materials, Wiley, Vol. 32, No. 35 ( 2022-08)
    Abstract: NiFe‐based hydroxides are considered as promising nonprecious catalysts for water oxidation due to their low cost and easy preparation. However, the rational design of NiFe‐based electrocatalysts remains a great challenge to address the sluggish reaction kinetics and severe deactivation problems for oxygen evolution reaction (OER). Here, the authors report a facile approach to fabricate an amorphous Ce‐doped NiFe hydroxide catalyst, which enables high activity and outstanding stability toward OER in alkaline media. The overpotential of electrodeposited amorphous Ce‐doped NiFe is only 195 mV at 10 mA cm −2 . Meanwhile, the durability of the amorphous Ce‐doped NiFe is maintained for 300 h at 100 mA cm −2 . The comprehensive characterization results reveal that the improved electrochemical performance of the amorphous Ce‐doped NiFe catalyst is originated from the favorable oxidation transition of active sites enabled by Ce‐doping. It is a very good strategy to introduce highly oxidized state ions to regulate the NiFe‐based catalyst to improve the catalytic activity and stability.
    Type of Medium: Online Resource
    ISSN: 1616-301X , 1616-3028
    URL: Issue
    URL: Article
    DOI: 10.1002/adfm.v32.35
    DOI: 10.1002/adfm.202204086
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2029061-5
    detail.hit.zdb_id: 2039420-2
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  • 9
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    Investigation on the dynamic behavior of composite gradient double‐arrow auxetic structure under local impact load
    Wiley ; 2022
    In:  Polymer Composites Vol. 43, No. 5 ( 2022-05), p. 3068-3084
    Details
    In: Polymer Composites, Wiley, Vol. 43, No. 5 ( 2022-05), p. 3068-3084
    Abstract: Based on the design concept of functionally graded materials, the composite gradient double‐arrow auxetic structures were designed and fabricated. The thickness of core layers demonstrates an increasing trend for positive gradient structure, while a decreasing trend for negative gradient structure. The thickness of core layers keeps constant for homogeneous structure. The dynamic response and failure modes of the double‐arrow auxetic structure with different gradient distributions of wall thickness were obtained by foam projectile impact experiments. The influence of the gradient distribution of core wall thickness on the impact resistance of composite double‐arrow auxetic structures under local impact load was investigated. The results demonstrated that the gradient distribution of core wall thickness has an important influence on the dynamic response and failure modes of the structure. The negative gradient auxetic structure revealed more excellent impact resistance compared with the positive gradient auxetic structure. In addition, the response of the gradient double‐arrow auxetic structure under local impact load was simulated by ABAQUS/Explicit, and the simulation results were in good agreement with the experimental results. Combined with the experimental and numerical simulation results, it was found that the negative gradient distribution of core wall thickness had an obvious improvement on the impact resistance of composite double‐arrow auxetic structure under local impact load.
    Type of Medium: Online Resource
    ISSN: 0272-8397 , 1548-0569
    URL: Issue
    URL: Article
    DOI: 10.1002/pc.v43.5
    DOI: 10.1002/pc.26600
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 1475935-4
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  • 10
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    A ratiometric fluorescent sensor for the detection of phosphate
    Wiley ; 2023
    In:  Luminescence Vol. 38, No. 2 ( 2023-02), p. 152-158
    Details
    In: Luminescence, Wiley, Vol. 38, No. 2 ( 2023-02), p. 152-158
    Abstract: Over the past few years, ratiometric fluorescent nanoprobes have garnered substantial interest because of their self‐calibration characteristics. This research developed a ratiometric fluorescent sensor to detect phosphate. Through encapsulating luminescent materials, gold nanoclusters (AuNCs) and carbon dots (CDs) into a zeolitic imidazolate framework‐8 (ZIF‐8), the fluorescence signal of AuNCs was enhanced, while that of CDs was suppressed. After phosphate was added, it could decompose ZIF‐8, and AuNCs and CDs were released, which weakened the fluorescence signal of the AuNCs while restoring that of the CDs. Thereby, this makes CDs/AuNCs@ZIF‐8 a potential fluorescent sensor for phosphate determination. The ratiometric sensor had facile synthesis, good selectivity, and a low detection limit. Therefore, this sensor was an effective tool for the detection of phosphate.
    Type of Medium: Online Resource
    ISSN: 1522-7235 , 1522-7243
    URL: Issue
    URL: Article
    DOI: 10.1002/bio.v38.2
    DOI: 10.1002/bio.4434
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2001819-8
    SSG: 12
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