In:
Journal of Chemical Research, SAGE Publications, Vol. 35, No. 5 ( 2011-05), p. 291-293
Abstract:
An efficient preparation of hydroxysteroids by a one-pot, simultaneously rapid deprotection of 3-acyloxy groups and reduction of D-ring ketones (nitrile) of steroids using DIBAL-H in the presence of NiCl 2 (10 mol %) is described. The attractive features of this procedure for the preparation of the hydroxysteroid derivatives are the mild reaction conditions, short reaction time, excellent yields, clean reaction profiles, and an inexpensive catalyst system.
Type of Medium:
Online Resource
ISSN:
1747-5198
,
2047-6507
DOI:
10.3184/174751911X13050949941793
Language:
English
Publisher:
SAGE Publications
Publication Date:
2011
detail.hit.zdb_id:
3010810-X
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