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  • Liu, Hsiu-Chih  (4)
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  • 1
    Online Resource
    Online Resource
    Statistical Parametric Mapping of Brain SPECT Perfusion Abnormalities in Patients with Alzheimer’s Disease
    S. Karger AG ; 2003
    In:  European Neurology Vol. 49, No. 3 ( 2003), p. 142-145
    Details
    In: European Neurology, S. Karger AG, Vol. 49, No. 3 ( 2003), p. 142-145
    Abstract: Brain perfusion in 20 patients with mild Alzheimer’s disease (AD), 20 patients with moderate AD and 20 control subjects (matched for age, gender and education) were assessed by single photon emission computed tomography (SPECT) using technetium-99m hexamethylpropylene amine oxime ( 〈 sup 〉 99m 〈 /sup 〉 Tc-HMPAO). SPECT images were transformed to a standard size and shape for group comparisons by the voxel-based t test of the statistical parametric mapping techniques. Cerebral hypoperfusion in the left lower parietal area was found in mild AD patients. In moderate AD patients, significant cerebral hypoperfusion was located in bilateral posterior parietotemporal cortices, contiguous anterior occipital lobes, posterior cingulate gyri and, to a lesser extent, in frontal areas.
    Type of Medium: Online Resource
    ISSN: 0014-3022 , 1421-9913
    URL: Article
    DOI: 10.1159/000069086
    RVK:
    XA 10000
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2003
    detail.hit.zdb_id: 1482237-4
    Location Call Number Limitation Availability
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    Online Resource
  • 2
    Online Resource
    Online Resource
    Selective Hypoperfusion of Anterior Cingulate Gyrus in Depressed AD Patients: A Brain SPECT Finding by Statistical Parametric Mapping
    S. Karger AG ; 2003
    In:  Dementia and Geriatric Cognitive Disorders Vol. 16, No. 4 ( 2003), p. 238-244
    Details
    In: Dementia and Geriatric Cognitive Disorders, S. Karger AG, Vol. 16, No. 4 ( 2003), p. 238-244
    Abstract: This study tests the hypothesis that depression in patients with Alzheimer’s disease (AD) is due to a specific pathogenesis rather than a reactive phenomenon. Forty-three AD patients received a psychiatrist’s interview, neuropsychological assessments, and a 〈 sup 〉 99m 〈 /sup 〉 Tc-hexamethyl propyleneamine oxime single photon emission computed tomography (HMPAO-SPECT). Analysis by statistical parametric mapping (SPM) showed that the depressed group had selective hypoperfusion in the bilateral anterior and posterior cingulate gyri and precuneus. Using the Hamilton Depression Rating Scale as a parameter, an inverse correlation was found between cerebral perfusion and the severity of depression. The right anterior cingulate gyrus demonstrated a most significant reduction in perfusion. These locations are akin to the imaging findings in patients with primary depression, indicating a specific pathogenesis for depression in AD.
    Type of Medium: Online Resource
    ISSN: 1420-8008 , 1421-9824
    URL: Article
    DOI: 10.1159/000072808
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2003
    detail.hit.zdb_id: 1482186-2
    Location Call Number Limitation Availability
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    Online Resource
  • 3
    Online Resource
    Online Resource
    Longitudinal Cerebral Perfusion Decrease in Mild Alzheimer’s Disease Revealed by SPECT with Statistical Parametric Mapping Method
    S. Karger AG ; 2004
    In:  European Neurology Vol. 52, No. 1 ( 2004), p. 42-49
    Details
    In: European Neurology, S. Karger AG, Vol. 52, No. 1 ( 2004), p. 42-49
    Abstract: Fifteen patients with mild Alzheimer’s disease received baseline and follow-up technetium-99m hexamethylpropylene amine oxime SPECT examinations paired with neuropsychological assessments, including the Cognitive Ability Screening Instruments (CASI). The differences between baseline and follow-up SPECT images were analyzed by the voxel-based paired t test of the statistical parametric mapping technique. A simple regression analysis was also conducted to analyze the correlation between CASI sub-scores and both sets of SPECT images. In comparison with baseline images, cerebral perfusion at follow-up was significantly reduced in the left superior and middle temporal gyri, right middle and inferior temporal gyri, and right fusiform gyrus. A significant correlation was demonstrated between the list-generating fluency CASI sub-score and perfusion of the left fusiform gyrus. The visual construction sub-score was significantly correlated with perfusion of the right superior and medial frontal gyri.
    Type of Medium: Online Resource
    ISSN: 0014-3022 , 1421-9913
    URL: Article
    DOI: 10.1159/000079417
    RVK:
    XA 10000
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2004
    detail.hit.zdb_id: 1482237-4
    Location Call Number Limitation Availability
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    Online Resource
  • 4
    Online Resource
    Online Resource
    Cognitive Reserve: A SPECT Study of 132 Alzheimer’s Disease Patients with an Education Range of 0–19 Years
    S. Karger AG ; 2005
    In:  Dementia and Geriatric Cognitive Disorders Vol. 20, No. 1 ( 2005), p. 8-14
    Details
    In: Dementia and Geriatric Cognitive Disorders, S. Karger AG, Vol. 20, No. 1 ( 2005), p. 8-14
    Abstract: This study examines the associations between education, cerebral perfusion, and cognitive test performance among 132 patients with Alzheimer’s disease. The participants had had between 0 and 19 years of formal schooling, and had either mild or moderate dementia according to the Clinical Dementia Rating Scale. Cerebral perfusion was evaluated by the 〈 sup 〉 99m 〈 /sup 〉 Tc-hexamethylpropylene amine oxime single photon emission computed tomography. The Mini-Mental State Examination and the Cognitive Abilities Screening Instrument were used to assess cognitive performance. For patients at each clinical dementia severity level, statistical parametric mapping was used to examine voxel by voxel the association between education and cerebral perfusion, and Pearson’s correlation coefficients were calculated between education and cognitive test scores. Years of formal schooling had negative associations with cerebral perfusion and positive associations with cognitive test scores. The brain regions showing a significant education effect on perfusion involved bilateral posterior association areas in mild dementia, and bilateral parieto-temporo-frontal areas in moderate dementia. The present findings indicate that the cognitive reserve effect starts at the low end of the education range. They also suggest that the main effect of more education is a more facile use of alternative brain circuits instead of locally increased synaptic connections.
    Type of Medium: Online Resource
    ISSN: 1420-8008 , 1421-9824
    URL: Article
    DOI: 10.1159/000085068
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2005
    detail.hit.zdb_id: 1482186-2
    Location Call Number Limitation Availability
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    Online Resource
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