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  • 1
    Online Resource
    Online Resource
    miR-30 Family: A Promising Regulator in Development and Disease
    Hindawi Limited ; 2018
    In:  BioMed Research International Vol. 2018 ( 2018-05-29), p. 1-8
    Details
    In: BioMed Research International, Hindawi Limited, Vol. 2018 ( 2018-05-29), p. 1-8
    Abstract: MicroRNAs (miRNAs) are small noncoding RNAs that negatively regulate posttranscriptional expression of target genes. Accumulating evidences have demonstrated that the miR-30 family, as a member of microRNAs, played a crucial regulating role in the development of tissues and organs and the pathogenesis of clinical diseases, which indicated that it may be a promising regulator in development and disease. This review aims to clarify the current progress on the regulating role of miR-30 family in tissues and organs development and related disease and highlight their research prospective in the future.
    Type of Medium: Online Resource
    ISSN: 2314-6133 , 2314-6141
    URL: Article
    DOI: 10.1155/2018/9623412
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2018
    detail.hit.zdb_id: 2698540-8
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  • 2
    Online Resource
    Online Resource
    Modified Suanzaorentang Had the Treatment Effect for Generalized Anxiety Disorder for the First 4 Weeks of Paroxetine Medication: A Pragmatic Randomized Controlled Study
    Hindawi Limited ; 2017
    In:  Evidence-Based Complementary and Alternative Medicine Vol. 2017 ( 2017), p. 1-8
    Details
    In: Evidence-Based Complementary and Alternative Medicine, Hindawi Limited, Vol. 2017 ( 2017), p. 1-8
    Abstract: Background . Paroxetine does not show satisfactory therapeutic effect for generalized anxiety disorder (GAD) patients for the first 2–4 weeks of medication. Diazepam is always concurrently used although it has some shortcomings such as physical dependence and withdrawal reactions. In this study, we aimed to identify whether modified Suanzaorentang (MSZRT), a combined Chinese formula including Suanzaorentang (SZRT) and Zhizichitang (ZZCT), could control the anxiety of GAD for the first 4 weeks of paroxetine medication. Methods . 156 GAD patients were randomized to the treatment of paroxetine, paroxetine-diazepam, or paroxetine-MSZRT for 4 weeks. Hamilton Anxiety Scale (HAMA) Test and Self-Rating Anxiety Scale (SAS) Test were determined each week as the evaluation of clinical efficacy. Adverse events (AEs) were also closely observed by performing the Treatment Emergent Symptom Scale (TESS) Test. Results . Both paroxetine-MSZRT and paroxetine-diazepam decreased more HAMA and SAS total scores than paroxetine from weeks 1 to 3. Paroxetine-MSZRT as well as paroxetine-diazepam had an obviously higher onset rate than paroxetine in each week. After 4 weeks’ treatment, the overall effectiveness rate in the paroxetine-MSZRT group (90.00%) was obviously higher than those of the paroxetine group (74.42%) but did not significantly differ from the paroxetine-diazepam group (93.88%). Conclusion . MSZRT had the treatment effect for GAD when paroxetine was used for the first 4 weeks.
    Type of Medium: Online Resource
    ISSN: 1741-427X , 1741-4288
    URL: Article
    DOI: 10.1155/2017/8391637
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2017
    detail.hit.zdb_id: 2148302-4
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  • 3
    Online Resource
    Online Resource
    Suan Zao Ren Tang in Combination with Zhi Zi Chi Tang as a Treatment Protocol for Insomniacs with Anxiety: A Randomized Parallel-Controlled Trial
    Hindawi Limited ; 2015
    In:  Evidence-Based Complementary and Alternative Medicine Vol. 2015 ( 2015), p. 1-7
    Details
    In: Evidence-Based Complementary and Alternative Medicine, Hindawi Limited, Vol. 2015 ( 2015), p. 1-7
    Abstract: Insomnia is a serious worldwide health problem that is often comorbid with anxiety. The purpose of the present study was to evaluate the efficacy of a Chinese formula containing Suan Zao Ren Tang (SZRT) and Zhi Zi Chi Tang (ZZCT; SZR-ZZC) for improving sleep quality and anxiety states with four indices of Polysomnography (PSG), the Insomnia Severity Index (ISI), the Pittsburgh Sleep Quality Index (PSQI), and the Self Rating Anxiety Scale (SAS). Methods. A randomized, parallel-controlled trial compared SZR-ZZC to lorazepam tablet in insomniacs with anxiety. Patients were randomized to the SZR-ZZC treatment group ( n = 60 ) and the lorazepam tablet treatment group ( n = 59 ). Results . SZR-ZZC significantly improved scores on all four treatment indices. Compared with lorazepam, treatment with SZR-ZZC resulted in a significant reduction in the ISI ( P = 0.029 ), the PSQI ( P = 0.017 ), and wake after sleep onset (WASO; P = 0.008 ) scores and improved sleep architecture ( P = 0.000 –0.003) after a 4-week treatment period. Only one subject in the SZR-ZZC group experienced adverse side effects. Conclusion . Treatment with SZR-ZZC for 4 weeks appears to be a relatively safe and effective complementary therapeutic option when aiming to improve sleep quality and anxiety in insomniacs with anxiety.
    Type of Medium: Online Resource
    ISSN: 1741-427X , 1741-4288
    URL: Article
    DOI: 10.1155/2015/913252
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2015
    detail.hit.zdb_id: 2148302-4
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  • 4
    Online Resource
    Online Resource
    Efficacy and Safety of Jiawei Suanzaoren Decoction Combined with Lorazepam for Chronic Insomnia: A Parallel-Group Randomized Controlled Trial
    Hindawi Limited ; 2020
    In:  Evidence-Based Complementary and Alternative Medicine Vol. 2020 ( 2020-02-08), p. 1-8
    Details
    In: Evidence-Based Complementary and Alternative Medicine, Hindawi Limited, Vol. 2020 ( 2020-02-08), p. 1-8
    Abstract: Background . Chronic insomnia is a major public health problem, but there are limited effective therapies. Jiawei Suanzaoren Decoction (JW-SZRD) has been used as an alternative option for treating insomnia. This study aimed to investigate the long-term efficacy and safety of JW-SZRD in combination with lorazepam for chronic insomnia. Methods . A total of 207 participants were analyzed in this study. The treatment group (TG) received JW-SZRD and lorazepam orally, and the control group (CG) received lorazepam alone. The Insomnia Severity Index (ISI), the Self-Rating Depression Scale (SDS), the Self-Rating Anxiety Scale (SAS), and the Somatic Self-rating Scale (SSS) were evaluated at baseline, weeks 4, 8, and 12. The MOS 36-item Short Form Health Survey (SF-36) was assessed at baseline and week 12. Adverse effects (AEs) were evaluated by the Treatment Emergent Symptom Scale (TESS). Results . Both TG and CG showed obvious improvements in the sleep onset latency (SOL) ( P = 0.001 and 0.005) and total sleep time (TST) ( P = 0.0001 and 0.001). However, TG was more effective than CG at weeks 8 ( P = 0.02 for SOL, P = 0.008 for TST) and 12 ( P = 0.03 for SOL, P = 0.04 for TST), especially in shortening SOL (Cohen’s d  = 1.28). The ISI reduction rate in TG was higher than that in CG at weeks 4, 8, and 12 ( P = 0.008 , 0.001 and 0.001). After treatment, TG had lower SAS scores ( P = 0.0001 , 0.007), less somatic symptoms ( P 〈 0.05 or 0.01), higher SF-36 scores ( P 〈 0.05 or 0.01), better compliance ( P = 0.0001 ), and less adverse effects ( P 〈 0.05 or 0.01) than those in CG. Conclusion . The combination of JW-SZRD with lorazepam can significantly improve sleep quality with fewer AEs. It is an effective treatment and superior to lorazepam alone for chronic insomnia.
    Type of Medium: Online Resource
    ISSN: 1741-427X , 1741-4288
    URL: Article
    DOI: 10.1155/2020/3450989
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2020
    detail.hit.zdb_id: 2148302-4
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  • 5
    Online Resource
    Online Resource
    Research on Neck Response of Elderly Drivers in Rear Collision
    Hindawi Limited ; 2022
    In:  BioMed Research International Vol. 2022 ( 2022-6-7), p. 1-13
    Details
    In: BioMed Research International, Hindawi Limited, Vol. 2022 ( 2022-6-7), p. 1-13
    Abstract: In order to study the neck response of elderly drivers in rear collision, a finite element model for elderly neck was built. By comparing the cadaver experiment data in the literature, the simulation reliability of the head and neck model of the elderly under dynamic load was verified. Through the C-NCAP rear-end collision test on the elderly model, the study showed that the neck of the elderly driver had good dynamic response characteristics. The verified finite element model was used to analyze the head and neck collision response and injury risk of the elderly under different distances between the head and the headrest (vertical distance and horizontal distance). By analyzing the head and neck injuries of occupants at different distances, it was found that when the horizontal distance was 50 mm, and the vertical distance was between +10 and ~+20 mm, the headrest could play the best role in protecting the neck of the elderly driver and could reduce the degree of injury of the elderly driver in the process of rear collision.
    Type of Medium: Online Resource
    ISSN: 2314-6141 , 2314-6133
    URL: Article
    DOI: 10.1155/2022/5239515
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2698540-8
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  • 6
    Online Resource
    Online Resource
    An Osgood Type Regularity Criterion for the 3D Boussinesq Equations
    Hindawi Limited ; 2014
    In:  The Scientific World Journal Vol. 2014 ( 2014), p. 1-4
    Details
    In: The Scientific World Journal, Hindawi Limited, Vol. 2014 ( 2014), p. 1-4
    Abstract: We consider the three-dimensional Boussinesq equations, and obtain an Osgood type regularity criterion in terms of the velocity gradient.
    Type of Medium: Online Resource
    ISSN: 2356-6140 , 1537-744X
    URL: Article
    DOI: 10.1155/2014/563084
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2014
    detail.hit.zdb_id: 2075968-X
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  • 7
    Online Resource
    Online Resource
    Physical-Layer Channel Authentication for 5G via Machine Learning Algorithm
    Hindawi Limited ; 2018
    In:  Wireless Communications and Mobile Computing Vol. 2018 ( 2018-10-02), p. 1-10
    Details
    In: Wireless Communications and Mobile Computing, Hindawi Limited, Vol. 2018 ( 2018-10-02), p. 1-10
    Abstract: By utilizing the radio channel information to detect spoofing attacks, channel based physical layer (PHY-layer) enhanced authentication can be exploited in light-weight securing 5G wireless communications. One major obstacle in the application of the PHY-layer authentication is its detection rate. In this paper, a novel authentication method is developed to detect spoofing attacks without a special test threshold while a trained model is used to determine whether the user is legal or illegal. Unlike the threshold test PHY-layer authentication method, the proposed AdaBoost based PHY-layer authentication algorithm increases the authentication rate with one-dimensional test statistic feature. In addition, a two-dimensional test statistic features authentication model is presented for further improvement of detection rate. To evaluate the feasibility of our algorithm, we implement the PHY-layer spoofing detectors in multiple-input multiple-output (MIMO) system over universal software radio peripherals (USRP). Extensive experiences show that the proposed methods yield the high performance without compromising the computing complexity.
    Type of Medium: Online Resource
    ISSN: 1530-8669 , 1530-8677
    URL: Article
    DOI: 10.1155/2018/6039878
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2018
    detail.hit.zdb_id: 2045240-8
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  • 8
    Online Resource
    Online Resource
    A Semi-Markov Process Model for Performance Evaluation of DSRC Vehicular Safety Communication
    Hindawi Limited ; 2022
    In:  Mathematical Problems in Engineering Vol. 2022 ( 2022-10-22), p. 1-11
    Details
    In: Mathematical Problems in Engineering, Hindawi Limited, Vol. 2022 ( 2022-10-22), p. 1-11
    Abstract: In this study, a new semi-Markov process (SMP)-based model is devised to evaluate the IEEE 802.11p enhanced distributed channel access (EDCA) broadcast performance for vehicular safety communication. Differing from the existing SMP analytical models, the proposed model takes the virtual collision among various prioritized access categories (ACs) inside each vehicle into consideration. Moreover, in contrast to the Markov chain-based models, our model is simpler but with approximate accuracy. Concretely, we first capture the behavior of each AC’s backoff entity using SMP. Then, the parameters of interest in the vehicular ad hoc network (VANET) such as packet transmission probability, conditional collision probability, and saturation throughput are derived. Finally, via MATLAB simulations, we demonstrate that the newly developed model achieves comparable accuracy in calculating these output parameters while its complexity and computation time is around one-tenth of that of the Markov chain-based models. Therefore, the proposed model is more suitable for real-time performance analysis of IEEE 802.11p EDCA safety communication in a freeway scenario.
    Type of Medium: Online Resource
    ISSN: 1563-5147 , 1024-123X
    URL: Article
    DOI: 10.1155/2022/7548608
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2014442-8
    SSG: 11
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  • 9
    Online Resource
    Online Resource
    Sesamin: A Naturally Occurring Lignan Inhibits CYP3A4 by Antagonizing the Pregnane X Receptor Activation
    Hindawi Limited ; 2012
    In:  Evidence-Based Complementary and Alternative Medicine Vol. 2012 ( 2012), p. 1-15
    Details
    In: Evidence-Based Complementary and Alternative Medicine, Hindawi Limited, Vol. 2012 ( 2012), p. 1-15
    Abstract: Inconsistent expression and regulation of drug-metabolizing enzymes (DMEs) are common causes of adverse drug effects in some drugs with a narrow therapeutic index (TI). An important cytochrome, cytochrome P450 3A4 (CYP3A4), is predominantly regulated by a nuclear receptor, pregnane X receptor (PXR). Sesamin, a major lignan constituent in sesame seeds and oil, exhibits a variety of biological functions; however, the effect of sesamin on the modulation of CYP3A4 is not well understood. In this study, the effects of sesamin on the PXR-CYP3A4 pathway were characterized, as well as the underlying mechanisms of those effects. Sesamin potently attenuated CYP3A4 induction in a dose-dependent manner by blocking the activation of PXR. The PXR inducer-mediated inhibition of CYP3A4 was further evidenced by the ability of sesamin to attenuate the effects of several PXR ligands in the CYP3A4 reporter assay. Further mechanistic studies showed that sesamin inhibited PXR by interrupting the interacting with coregulators. These results may lead to the development of new therapeutic and dietary approaches to reduce the frequency of inducer-drug interaction. Sesamin was established as a novel inhibitor of PXR and may be useful for modulating DMEs expression and drug efficacies. Modification of CYP3A4 expression and activity by consumption of sesamin may have important implications for drug safety.
    Type of Medium: Online Resource
    ISSN: 1741-427X , 1741-4288
    URL: Article
    DOI: 10.1155/2012/242810
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2012
    detail.hit.zdb_id: 2148302-4
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  • 10
    Online Resource
    Online Resource
    Nomogram for Predicting Deep Venous Thrombosis in Lower Extremity Fractures
    Hindawi Limited ; 2021
    In:  BioMed Research International Vol. 2021 ( 2021-6-22), p. 1-8
    Details
    In: BioMed Research International, Hindawi Limited, Vol. 2021 ( 2021-6-22), p. 1-8
    Abstract: Deep venous thrombosis (DVT) is a common complication in patients with lower extremity fractures, causing delays in recovery short-term and possible impacts on quality of life long-term. Early prediction and prevention of thrombosis can effectively reduce patient pain while improving outcomes. Although research on the risk factors for thrombosis is prevalent, there is a stark lack of clinical predictive models for DVT occurrence specifically in patients with lower limb fractures. In this study, we aim to propose a new thrombus prediction model for lower extremity fracture patients. Data from 3300 patients with lower limb fractures were collected from Wuhan Union Hospital and Hebei Third Hospital, China. Patients who met our inclusion criteria were divided into a thrombosis and a nonthrombosis group. A multivariate logistic regression analysis was carried out to identify predictors with obvious effects, and the corresponding formulas were used to establish the model. Model performance was evaluated using a discrimination and correction curve. 2662 patients were included in the regression analysis, with 1666 in the thrombosis group and 996 in the nonthrombosis group. Predictive factors included age, Body Mass Index (BMI), fracture-fixation types, energy of impact at the time of injury, blood transfusion during hospitalization, and use of anticoagulant drugs. The discriminative ability of the model was verified using the C-statistic (0.676). For the convenience of clinical use, a score table and nomogram were compiled. Data from two centers were used to establish a novel thrombus prediction model specific for patients with lower limb fractures, with verified predictive ability.
    Type of Medium: Online Resource
    ISSN: 2314-6141 , 2314-6133
    URL: Article
    DOI: 10.1155/2021/9930524
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2698540-8
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