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  • Wiley  (60)
  • Liu, An  (60)
  • 1
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    Scutellarin ameliorates the stress‐induced anxiety‐like behaviors in mice by regulating neurotransmitters
    Wiley ; 2021
    In:  Phytotherapy Research Vol. 35, No. 7 ( 2021-07), p. 3936-3944
    Details
    In: Phytotherapy Research, Wiley, Vol. 35, No. 7 ( 2021-07), p. 3936-3944
    Abstract: Anxiety disorders are a common frequently psychiatric symptom in patients that lead to disruption of daily life. Scutellarin (Scu) is the main component of Erigeron breviscapus , which has been used as a neuroprotective agent against glutamate‐induced excitotoxicity. However, the potential effect of Scu on the stress‐related neuropsychological disorders has not been clarified. In this study, Anxiety‐like behavior was induced by acute restraint stress in mice. Scu were injected intraperitoneally (twice daily, 3 days). Results showed that Scu exhibited good protective activity on mice by decreasing transmitter release levels. Restraint stress caused significant anxiety like behavior in mice. Treatment of Scu could significantly improve the moving time of open arms in Elevated Plus Maze and central time on open field test. Scu treatment suppressed action potential firing frequency, restored excessive presynaptic quantal release, and down‐regulated glutamatergic receptor expression levels in the prefrontal cortex (PFC) of stressed mice. GABA A Rα1 and GABA A γ 2 expression in the brain PFC tissues of mice were nearly abrogated by Scu treatment. In stress‐induced anxiety mice, stress can increase the frequency of mini excitatory postsynaptic currents (mEPSC), which can be reversed by Scu treatment. Therefore, Scu has a potent anxiolytic activity and may be valuable for the treatment of stress‐induced anxiety disorders.
    Type of Medium: Online Resource
    ISSN: 0951-418X , 1099-1573
    URL: Issue
    URL: Article
    DOI: 10.1002/ptr.v35.7
    DOI: 10.1002/ptr.7106
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 1493490-5
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  • 2
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    Compact wideband MIMO antenna with fragmented patches for 5G mobile terminals
    Wiley ; 2023
    In:  Microwave and Optical Technology Letters
    Details
    In: Microwave and Optical Technology Letters, Wiley
    Abstract: A compact wideband MIMO antenna obtained by breaking up an intact rectangular patch into a 2 × 5 small patch array with connected strips is proposed for 5G mobile terminals. The diagonal small patches are connected with the metal strips respectively, so as to constitute an interleaved double branch composed of a main branch and a parasitic branch, thus achieving compactness. The main branch fed by two ports operates at 4.5 GHz, and the parasitic branch coupled by the main branch achieves a lower resonant frequency of 3.35 GHz, thus widening the bandwidth. The small patches in the middle are connected to the ground to improve the isolation. A short length of 21.5 mm (about 0.24 wavelength of the lower‐edge frequency) of the proposed antenna pair is realized. Besides, an eight‐element MIMO antenna is designed and fabricated. Measured results show the reflection coefficients are lower than −6 dB, and the transmission coefficients between every two ports are lower than −10 dB in the 5G N77/N78/N79 bands (3.3–5.0 GHz). The average total efficiencies are 70.4% and 63.8% for antenna 1 and antenna 2, respectively. The ECCs are lower than 0.15.
    Type of Medium: Online Resource
    ISSN: 0895-2477 , 1098-2760
    URL: Article
    DOI: 10.1002/mop.33901
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2000574-X
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  • 3
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    Transcriptome Analysis of Potential miRNA Involved in Adipogenic Differentiation of C2C12 Myoblasts
    Wiley ; 2018
    In:  Lipids Vol. 53, No. 4 ( 2018-04), p. 375-386
    Details
    In: Lipids, Wiley, Vol. 53, No. 4 ( 2018-04), p. 375-386
    Abstract: 〉 Emerging evidence indicates that microRNA (miRNA) plays an important role in adipogenesis and disease pathogenesis. To investigate the miRNA involved in regulating different periods of adipogenesis, we performed a comprehensive study on microRNAome during the stimulation of adipogenesis by an adipogenic differentiation cocktail in C2C12 myoblasts at 0, 2, 4, and 7 days using the Solexa sequencing technology. In this study, we identified 52 differentially expressed (DE) miRNA. Functional annotation indicated that the target genes of DE miRNA were mostly enriched in adipogenic transdifferentiation and fat metabolism‐related pathways, including Wnt, mitogen‐activated protein kinase (MAPK), and insulin signaling. The insulin signaling pathway was further analyzed for its close connections to Wnt and MAPK signaling pathways as well as for the containing of thymoma viral proto‐oncogene‐3 ( Akt3 ) and glycogen synthase kinase‐3 beta ( Gsk3b ), which were both target genes predicted by most DE miRNA. CLIP‐seq (crosslinking‐immunprecipitation and high‐throughput sequencing) data showed that Akt3 was targeted by seven DE miRNA, including five upregulated (miR‐203‐3p, miR‐181c‐5p, miR‐322‐5p, miR‐351‐5p, and miR‐181a‐5p) and two downregulated (miR‐15b‐5p and miR‐17‐5p) ones. Likewise, Gsk3b was targeted by six DE miRNA, including four upregulated (miR‐199a‐3p, miR‐126‐5p, miR‐26a‐5p, and miR‐101a‐3p) and two downregulated (miR‐150‐5p and miR‐140‐3p) ones. Moreover, Akt3 could regulate the key transcription factor (TF) Foxo1 , targeted by two downregulated miRNA (miR‐96‐5p and miR‐183‐5p). The expression levels of Akt3 and Gsk3b were downregulated, and TF Foxo1 , which worked on the transcription axis of Pgc1a–Pparα–Rxrg–Pparγ to regulate adipogenesis, was upregulated. In conclusion, DE miRNA stimulated the adipogenesis of C2C12 myoblasts through the targeted insulin signaling pathway involving the genes Akt3 , Gsk3b , and TF Foxo1 .
    Type of Medium: Online Resource
    ISSN: 0024-4201 , 1558-9307
    URL: Issue
    URL: Article
    DOI: 10.1002/lipd.2018.53.issue-4
    DOI: 10.1002/lipd.12032
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 2030265-4
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  • 4
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    HIV RNA and proviral HIV DNA can be detected in semen after 6 months of antiretroviral therapy although HIV RNA is undetectable in blood
    Wiley ; 2016
    In:  Microbiology and Immunology Vol. 60, No. 3 ( 2016-03), p. 187-195
    Details
    In: Microbiology and Immunology, Wiley, Vol. 60, No. 3 ( 2016-03), p. 187-195
    Abstract: The risk of sexual transmission of HIV is strongly correlated with amounts of genital HIV RNA. Few studies have reported amounts of HIV RNA and HIV DNA in semen in HIV‐infected Chinese patients undergoing antiviral treatment (ART). In this observational study, the amounts of HIV RNA and HIV DNA in semen were assessed after six months of ART in HIV‐infected Chinese individuals, when HIV RNA was undetectable in blood . This study included 19 HIV‐infected Chinese men undergoing ART for six months. Amounts of HIV in paired semen and blood samples were assessed using real‐time PCR. The C2‐V5 region of the HIV envelope ( env ) genes was cloned and sequenced and genotype and co‐receptor usage predicted based on the sequence. It was found that HIV RNA was undetectable in the plasma of most patients (17/19), whereas HIV RNA could be detected in the semen of most patients (16/19). HIV DNA could be detected in both semen and blood. Genetic diversity of HIV between the seminal and blood compartments was identified. Thus, amounts of HIV RNA and HIV DNA remain high in semen of HIV‐infected Chinese patients after six months of ART treatment, even when HIV RNA was undetectable in blood.
    Type of Medium: Online Resource
    ISSN: 0385-5600 , 1348-0421
    URL: Issue
    URL: Article
    DOI: 10.1111/mim.v60.3
    DOI: 10.1111/1348-0421.12361
    Language: English
    Publisher: Wiley
    Publication Date: 2016
    detail.hit.zdb_id: 2102145-4
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  • 5
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    Down-regulation of ING4 is associated with initiation and progression of lung cancer : Down-regulation of ING4 in lung cancer
    Wiley ; 2010
    In:  Histopathology Vol. 57, No. 2 ( 2010-08), p. 271-281
    Details
    In: Histopathology, Wiley, Vol. 57, No. 2 ( 2010-08), p. 271-281
    Type of Medium: Online Resource
    ISSN: 0309-0167
    URL: Article
    DOI: 10.1111/j.1365-2559.2010.03623.x
    RVK:
    XA 10000
    Language: English
    Publisher: Wiley
    Publication Date: 2010
    detail.hit.zdb_id: 2006447-0
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  • 6
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    UV-B-induced Oxidative Damage and Protective Role of Exopolysaccharides in Desert Cyanobacterium Microcoleus vaginatus
    Wiley ; 2009
    In:  Journal of Integrative Plant Biology Vol. 51, No. 2 ( 2009-02), p. 194-200
    Details
    In: Journal of Integrative Plant Biology, Wiley, Vol. 51, No. 2 ( 2009-02), p. 194-200
    Type of Medium: Online Resource
    ISSN: 1672-9072 , 1744-7909
    URL: Issue
    URL: Article
    DOI: 10.1111/jipb.2009.51.issue-2
    DOI: 10.1111/j.1744-7909.2008.00784.x
    Language: English
    Publisher: Wiley
    Publication Date: 2009
    detail.hit.zdb_id: 2130095-1
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  • 7
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    Morphology and Molecular Phylogeny of a New Marine Hypotrichous Ciliate, Hypotrichidium paraconicum n. sp. (Ciliophora, Hypotrichia)
    Wiley ; 2013
    In:  Journal of Eukaryotic Microbiology Vol. 60, No. 6 ( 2013-11), p. 588-600
    Details
    In: Journal of Eukaryotic Microbiology, Wiley, Vol. 60, No. 6 ( 2013-11), p. 588-600
    Abstract: A new saline hypotrich, Hypotrichidium paraconicum n. sp., found in coastal waters near Hong Kong, China, was investigated with emphasis on its living morphology, infraciliature, ontogenesis, and phylogenetic position. A body that is pyriform, with a posterior end that is twisted helically toward the left, a distinct tail and a dark colour, characterizes H. paraconicum n. sp. The buccal cavity is prominent and the cortical granules, which are scattered or sparsely distributed, are colourless, round, and about 1 μm in diam. The contractile vacuole is near the left middle of the cell and there are one or two frontal cirri, four meridional rows and five or six cirral rows which exhibit a left‐handed spiral and which are distributed in the posterior portion on both sides. Three dorsal kineties are distributed in the anterior portion of the dorsal side. In our molecular phylogenies, based on SSU rRNA gene sequences, the position of H. paraconicum n. sp. is rather poorly resolved, providing some indication of a relationship with Neokeronopsis aurea and Rubrioxytricha ferruginea , which fall into the assemblage of oxytrichids ( s.l .).
    Type of Medium: Online Resource
    ISSN: 1066-5234 , 1550-7408
    URL: Issue
    URL: Article
    DOI: 10.1111/jeu.2013.60.issue-6
    DOI: 10.1111/jeu.12064
    RVK:
    WA 15000
    Language: English
    Publisher: Wiley
    Publication Date: 2013
    detail.hit.zdb_id: 2126326-7
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  • 8
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    Matrine attenuates high‐fat diet‐induced in vivo and ox‐LDL‐induced in vitro vascular injury by regulating the PKCα/eNOS and PI3K/Akt/eNOS pathways
    Wiley ; 2019
    In:  Journal of Cellular and Molecular Medicine Vol. 23, No. 4 ( 2019-04), p. 2731-2743
    Details
    In: Journal of Cellular and Molecular Medicine, Wiley, Vol. 23, No. 4 ( 2019-04), p. 2731-2743
    Abstract: Lipid metabolism disorders lead to vascular endothelial injury. Matrine is an alkaloid that has been used to improve obesity and diabetes and for the treatment of hepatitis B. However, its effect on lipid metabolism disorders and vascular injury is unclear. Here, we investigated the effect of matrine on high‐fat diet fed mice and oxidized low‐density lipoprotein (ox‐LDL)‐induced human umbilical vein endothelial cells (HUVECs). Computational virtual docking analyses, phosphoinositide 3‐kinase (PI3K) and protein kinase C‐α (PKCα) inhibitors were used to localize matrine in vascular injuries. The results showed that matrine‐treated mice were more resistant to abnormal lipid metabolism and inflammation than vehicle‐treated mice and exhibited significantly alleviated ox‐LDL‐stimulated dysfunction of HUVECs, restored diminished nitric oxide release, decreased reactive oxygen species generation and increased expression phosphorylation of AKT‐Ser473 and endothelial nitric oxide synthase (eNOS)‐Ser1177. Matrine not only up‐regulates eNOS‐Ser1177 but also down‐regulates eNOS‐Thr495, a PKCα‐controlled negative regulator of eNOS. Using computational virtual docking analyses and biochemical assays, matrine was also shown to influence eNOS/NO via PKCα inhibition. Moreover, the protective effects of matrine were significantly abolished by the simultaneous application of PKCα and the PI3K inhibitor. Matrine may thus be potentially employed as a novel therapeutic strategy against high‐fat diet‐induced vascular injury.
    Type of Medium: Online Resource
    ISSN: 1582-1838 , 1582-4934
    URL: Issue
    URL: Article
    DOI: 10.1111/jcmm.2019.23.issue-4
    DOI: 10.1111/jcmm.14180
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 2076114-4
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  • 9
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    Residual setup errors in cranial stereotactic radiosurgery without six degree of freedom robotic couch: Frameless versus rigid immobilization systems
    Wiley ; 2020
    In:  Journal of Applied Clinical Medical Physics Vol. 21, No. 3 ( 2020-03), p. 87-93
    Details
    In: Journal of Applied Clinical Medical Physics, Wiley, Vol. 21, No. 3 ( 2020-03), p. 87-93
    Abstract: This IRB‐approved study was to compare the residual inter‐fractional setup errors and intra‐fractional motion of patients treated with cranial stereotactic radiosurgery without a 6 degree of freedom (DoF) couch. We evaluated both frameless non‐invasive vacuum‐suction immobilization (Aktina PinPoint) and TALON rigid screw immobilization. Materials and Methods Twenty consecutive patients treated by Varian TrueBeam STX or Tomotherapy were selected for data collection. The dose and number of fractions received by each patient ranged from 18 Gy in 1 fraction (SRS) to 25 Gy in 5 fractions (SRT). Twelve patients were immobilized using PinPoint, a frameless suction system (Aktina Medical, New York) and eight patients were immobilized using the TALON rigid screw system. Customized head cushions were used for all patients. Six Atkina patients received pre‐ and post‐treatment cone‐beam CT (CBCT) to evaluate the intra‐fractional motion of the Aktina system. The intra‐fractional motion with the TALON rigid screw system has been reported to be negligible and was not repeated in this study. All patients received pre‐treatment CBCT or megavoltage CT (MVCT) to assess inter‐fractional setup accuracy. Shifts to the final treatment position were determined based on matching bony anatomy in the pre‐treatment setup CT and the planning CT. Setup CT and planning CT were registered retrospectively based on bony anatomy using image registration software to quantify rotational and translational errors. Results For the frameless Aktina system, mean and standard deviation of the intra‐fractional motion were −0.5 ± 0.7 mm (lateral), 0.1 ± 0.9 mm (vertical), −0.5 ± 0.6 mm (longitudinal), −0.04 ± 0.18°(pitch), −0.1 ± 0.23°(yaw), and −0.03 ± 0.17°(roll) indicating negligible intra‐fractional motion. Inter‐fractional rotation errors were −0.10 ± 0.25° (pitch), −0.08 ± 0.16° (yaw), and −0.20 ± 0.41° (roll) for TALON rigid screw immobilization versus 0.20 ± 0.69° (pitch), 0.34 ± 0.56° (yaw), 0.35 ± 0.82° (roll) for frameless vacuum‐suction immobilization showing that the rigid immobilization setup is more reproducible than the frameless immobilization. Without rotational correction by a 6 DoF couch, residual registration error exists and increases with distance from the image fusion center. In a 3D vector space, a tumor located 5 cm from the center of image fusion would require a 0.9 mm margin with the TALON system and a 2.1 mm margin with Aktina. Conclusions With image‐guided radiotherapy, translational setup errors can be corrected by image registration between pre‐treatment setup CT and planning CT. However, rotational errors cannot be accounted for without a 6 DoF couch. Our study showed that the frameless Aktina immobilization system provided negligible intra‐fractional motion. The inter‐fractional rotation setup error using Aktina was larger than rigid immobilization with the TALON system. To treat a single lesion far from the center of image registration or for multiple lesions in a single plan, additional margin may be needed to account for the uncorrectable rotational setup errors.
    Type of Medium: Online Resource
    ISSN: 1526-9914 , 1526-9914
    URL: Issue
    URL: Article
    DOI: 10.1002/acm2.v21.3
    DOI: 10.1002/acm2.12828
    Language: English
    Publisher: Wiley
    Publication Date: 2020
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  • 10
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    Tanshinone IIA improves contextual fear‐ and anxiety‐like behaviors in mice via the CREB / BDNF / TrkB signaling pathway
    Wiley ; 2022
    In:  Phytotherapy Research Vol. 36, No. 10 ( 2022-10), p. 3932-3948
    Details
    In: Phytotherapy Research, Wiley, Vol. 36, No. 10 ( 2022-10), p. 3932-3948
    Abstract: Posttraumatic stress disorder (PTSD) is one of the most common psychiatric diseases, which is characterized by the typical symptoms such as re‐experience, avoidance, and hyperarousal. However, there are few drugs for PTSD treatment. In this study, conditioned fear and single‐prolonged stress were employed to establish PTSD mouse model, and we investigated the effects of Tanshinone IIA (TanIIA), a natural product isolated from traditional Chinese herbal Salvia miltiorrhiza , as well as the underlying mechanisms in mice. The results showed that the double stress exposure induced obvious PTSD‐like symptoms, and TanIIA administration significantly decreased freezing time in contextual fear test and relieved anxiety‐like behavior in open field and elevated plus maze tests. Moreover, TanIIA increased the spine density and upregulated synaptic plasticity‐related proteins as well as activated CREB/BDNF/TrkB signaling pathway in the hippocampus. Blockage of CREB remarkably abolished the effects of TanIIA in PTSD model mice and reversed the upregulations of p‐CREB, BDNF, TrkB, and synaptic plasticity‐related protein induced by TanIIA. The molecular docking simulation indicated that TanIIA could interact with the CREB‐binding protein. These findings indicate that TanIIA ameliorates PTSD‐like behaviors in mice by activating the CREB/BDNF/TrkB pathway, which provides a basis for PTSD treatment.
    Type of Medium: Online Resource
    ISSN: 0951-418X , 1099-1573
    URL: Issue
    URL: Article
    DOI: 10.1002/ptr.v36.10
    DOI: 10.1002/ptr.7540
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 1493490-5
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