In:
Journal of Physics: Conference Series, IOP Publishing, Vol. 2323, No. 1 ( 2022-08-01), p. 012030-
Abstract:
Nuclear magnetic resonance spectroscopy (NMR) probes using thin-film high temperature superconducting (HTS) resonators provide exceptional mass sensitivity in small-sample NMR experiments for natural products chemistry and metabolomics. We report improvements in sensitivity to our 1.5 mm 13 C-optimized NMR probe based on HTS resonators. The probe has a sample volume of 35 microliters and operates in a 14.1 T magnet. The probe also features HTS resonators for 1 H transmission and detection and the 2 H lock. The probe utilizes a 13 C resonator design that provides greater efficiency than our previous design. The quality factor of the new resonator in the 14.1 T background field was measured to be 4,300, which is over 3x the value of the previous design. To effectively implement the improved quality factor, we demonstrate the effect of adding a shorted transmission line stub to increase the bandwidth and reduce the rise/fall time of 13 C irradiation pulses. Initial NMR measurements verify 13 C NMR sensitivity is significantly improved while preserving detection bandwidth. The probe will be used for applications in metabolomics.
Type of Medium:
Online Resource
ISSN:
1742-6588
,
1742-6596
DOI:
10.1088/1742-6596/2323/1/012030
Language:
Unknown
Publisher:
IOP Publishing
Publication Date:
2022
detail.hit.zdb_id:
2166409-2
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