In:
Journal of Digestive Diseases, Wiley
Abstract:
We aimed to evaluate the association between LGI and the severity of patients with HTG‐AP. Methods We retrospectively reviewed 311 patients with HTG‐AP who were admitted to the Department of Fujian Provincial Hospital between April 2012 and March 2021. Inpatient medical and radiologic records were reviewed to determine clinical features, severity, and complications. C‐reactive protein (CRP) level, white blood cell (WBC) count, platelet (PLT) count, and neutrophil‐to‐lymphocyte ratio (NLR) were considered low‐grade inflammation biomarkers and were combined into a standardized LGI score. The association between the LGI score and the risk of severity of HTG‐AP was analyzed using univariate and multivariate logistic regression. Results Of the 311 patients with HTG‐AP studied, 47 (15.1%) patients met mild acute pancreatitis (MAP), 184 (59.2%) patients met moderately severe acute pancreatitis (MSAP), and 80 (25.7%) patients met severe acute pancreatitis (SAP). Patients with MSAP and SAP had a higher LGI score (median, 1.50 vs. ‐6.00; P 〈 0.001) than those with MAP. Univariate logistic regression analysis indicated that patients with LGI scores in the fourth quartile were more likely to have MSAP and SAP (odds ratio [OR], 21.925; 95% confidence interval [CI] , 5.014‐95.867; P 〈 0.001). The multivariate logistic regression analysis confirmed that low calcium (OR, 0.105; 95% CI, 0.011‐0.969; P=0.047) and high LGI score (OR, 1.253; 95% CI, 1.066‐1.473; P=0.006) were risk factors for MSAP and SAP. When predicting the severity of acute pancreatitis, the LGI score had the highest area under the ROC curve (AUC 0.7737) compared to individual biomarkers. Conclusions This study found that an elevated LGI score was associated with a higher risk of SAP in patients with HTG‐AP.
Type of Medium:
Online Resource
ISSN:
1751-2972
,
1751-2980
DOI:
10.1111/1751-2980.13231
Language:
English
Publisher:
Wiley
Publication Date:
2023
detail.hit.zdb_id:
2317117-0
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