In:
European Journal of Organic Chemistry, Wiley, Vol. 2009, No. 30 ( 2009-10), p. 5192-5197
Abstract:
A type of C 2 ‐symmetric secondary amine amide catalysts were developed for the asymmetric Michael addition of 4‐hydroxycoumarin to α,β‐unsaturated ketones. A series of important biologically and pharmaceutically active compounds were obtained in excellent yields (up to 99 %) with high enantioselectivities (up to 89 % ee ) under mild conditions. In addition, enantiopure product could be obtained by a single recrystallization. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)
Type of Medium:
Online Resource
ISSN:
1434-193X
,
1099-0690
DOI:
10.1002/ejoc.v2009:30
DOI:
10.1002/ejoc.200900831
Language:
English
Publisher:
Wiley
Publication Date:
2009
detail.hit.zdb_id:
1475010-7
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