In:
Chemistry – A European Journal, Wiley, Vol. 21, No. 21 ( 2015-05-18), p. 7709-7712
Abstract:
The first example of a N , N ′‐dioxide–Sc III ‐catalyzed 1,6‐addition of 3‐substituted oxindoles to dienyl ketones has been developed. This procedure tolerates a relatively wide range of 3‐substituted oxindoles under mild conditions, facilitating the preparation of various chiral oxindoles with quaternary stereocenters. In addition, the reliable catalyst was found to be effective in the asymmetric 1,6‐addition of both δ‐unsubstituted and δ‐methyl‐substituted dienyl ketones, achieving excellent regioselectivities and enantioselectivities (up to 〉 99 % ee ).
Type of Medium:
Online Resource
ISSN:
0947-6539
,
1521-3765
DOI:
10.1002/chem.201500833
Language:
English
Publisher:
Wiley
Publication Date:
2015
detail.hit.zdb_id:
1478547-X
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