GLORIA

GEOMAR Library Ocean Research Information Access

X

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Online Resource
    Online Resource
    0488 Trajectories of Insomnia Symptoms since Childhood Associated with Treatment of Internalizing Disorders in Adulthood
    Oxford University Press (OUP) ; 2022
    In:  Sleep Vol. 45, No. Supplement_1 ( 2022-05-25), p. A216-A216
    Details
    In: Sleep, Oxford University Press (OUP), Vol. 45, No. Supplement_1 ( 2022-05-25), p. A216-A216
    Abstract: Internalizing disorders (ID) are the most common form of psychopathology, with a large proportion of individuals seeking treatment in young adulthood. Childhood insomnia symptoms, i.e., difficulties initiating or maintaining sleep (DIMS), have been shown to be associated with ID, however, little is known about the developmental trajectories of insomnia symptoms and their associated risk of receiving pharmacotherapy for ID. The present study examined the longitudinal association between trajectories of childhood insomnia symptoms and risk of receiving treatment for ID in young adulthood. Methods We analyzed data from the Penn State Child Cohort, a population-based sample of 505 children (Mdn=9y), who were followed-up 8 years later as adolescents (Mdn=16y) and 15 years later as young adults (Mdn=24y). Insomnia symptoms were defined as parent-reported (childhood) or self-reported (adolescence and young adulthood) moderate-to-severe DIMS. The trajectories of insomnia symptoms across the three time-points were identified as never, remitted, waxing-and-waning, incident and persistent. The presence of ID was defined as a self-report of a diagnosis of mood and/or anxiety disorders, whether they had received treatment or not and whether treatment consisted of prescription psychotropic medication (i.e., antidepressants, anxiolytics). Logistic regression models were adjusted for sex, race/ethnicity, age, and any childhood or adolescent history of a psychiatric diagnosis or psychotropic medication use. Results Persistent (OR=3.0) and incident (OR=3.3) trajectories, but not waxing-and-waning (OR=1.1) or remitted (OR=0.8) trajectories, were associated with increased odds of ID that did not receive treatment in adulthood. Additionally, the odds of receiving treatment for ID with prescription psychotropic medication in adulthood were increased in those with persistent (OR=3.4), incident (OR=3.5) and waxing-and-waning (OR=2.1) trajectories, but not in those with a remitted trajectory (OR=0.7). Conclusion Childhood-onset persistent insomnia symptoms as well as adult-onset incident insomnia symptoms are strong risk factors for receiving treatment for mood/anxiety disorders in adulthood, while childhood insomnia symptoms that fully remit over time are not. Treatment of insomnia in youth should be an essential target as to decrease the risk of developing severe forms of mood/anxiety disorders requiring psychotropic treatment in adulthood. Support (If Any) National Institutes of Health (R01HL136587, R01MH118308, UL1TR000127)
    Type of Medium: Online Resource
    ISSN: 0161-8105 , 1550-9109
    URL: Article
    DOI: 10.1093/sleep/zsac079.485
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2022
    detail.hit.zdb_id: 2056761-3
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 2
    Online Resource
    Online Resource
    0006 Circadian Misalignment Increases the Impact of Visceral Adiposity on Metabolic Syndrome Burden in Adolescents
    Oxford University Press (OUP) ; 2023
    In:  SLEEP Vol. 46, No. Supplement_1 ( 2023-05-29), p. A3-A3
    Details
    In: SLEEP, Oxford University Press (OUP), Vol. 46, No. Supplement_1 ( 2023-05-29), p. A3-A3
    Abstract: Although insufficient sleep is a known risk factor for metabolic syndrome (MetS), the circadian timing of sleep is also involved in cardiac and metabolic regulation. As a result, circadian misalignment of the sleep-wake cycle, which is highly prevalent in adolescents, may independently impact the burden of MetS in youth. Methods We analyzed data from 277 population-based randomly-selected adolescents from the Penn State Child Cohort (median 16 years; 47% female; 21% racial/ethnic minority) who had at least 5 nights of at-home actigraphy (ACT), an in-lab 9-h polysomnography (PSG) and an in-lab dual-energy X-ray absorptiometry (DEXA) scan. Two ACT-measured metrics of circadian misalignment were examined as effect modifiers: sleep midpoint (SM), the intra-individual mean midpoint of the sleep period, and sleep regularity (SR), the intra-individual standard deviation of sleep midpoint. DEXA-measured visceral adipose tissue (VAT) was the primary predictor. A continuous MetS score (i.e., sum of the age and sex adjusted z-scores of waist circumference, blood pressure, HOMA-IR, triglycerides, and HDL cholesterol) was the primary outcome. Linear regression models tested SM and SR as effect modifiers of the association of VAT with MetS, while accounting for sex, race/ethnicity, age, ACT-sleep duration, ACT-sleep variability, and PSG-apnea/hypopnea index. Results A significant interaction was found between VAT and SR on MetS (p-interaction=0.05), while not between VAT and SM (p-interaction=0.15). Among adolescents with high sleep irregularity (≥ 45 minutes; n=164), each standard deviation increase in VAT was associated with 2.4 (0.2) standard deviations increase in MetS (p & lt; 0.01), while this association was weaker among adolescents with low sleep irregularity [ & lt; 45 minutes; n=113; β=1.7 (0.3), p & lt; 0.01]. Conclusion An irregular circadian timing of sleep may further increase the impact of visceral adiposity on MetS burden in adolescents. Sleep irregularity, independent of sleep apnea and insufficient sleep, may contribute to the development of cardiometabolic sequelae associated with central obesity. Support (if any) National Institutes of Health (R01HL136587, UL1TR000127) and American Heart Association (23PRE1011962)
    Type of Medium: Online Resource
    ISSN: 0161-8105 , 1550-9109
    URL: Article
    DOI: 10.1093/sleep/zsad077.0006
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2023
    detail.hit.zdb_id: 2056761-3
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 3
    Online Resource
    Online Resource
    0747 Association of a novel EEG biomarker of sleep depth with cardiac autonomic modulation in adolescents
    Oxford University Press (OUP) ; 2023
    In:  SLEEP Vol. 46, No. Supplement_1 ( 2023-05-29), p. A329-A330
    Details
    In: SLEEP, Oxford University Press (OUP), Vol. 46, No. Supplement_1 ( 2023-05-29), p. A329-A330
    Abstract: The odds ratio product (ORP), a continuous spectral EEG measure of sleep depth, increases in the transition to adolescence and with psychiatric/behavioral disorders; however, its association with cardiac physiology has been largely unexplored. Heart rate variability (HRV), a continuous spectral EKG measure of cardiac autonomic balance, includes HR oscillations at low frequencies (LF), the standard deviation between normal heart beats or R-R intervals (SDNN) and root mean square of successive differences between normal heartbeats (RMSSD), reflecting sympathetic vs. parasympathetic tone. We aimed to examine the longitudinal association of non-rapid eye movement (NREM) sleep ORP with 24-hour HRV in adolescents. Methods We studied 606 children (Md=9y), of whom 418 were followed-up as adolescents (Md=16y) from the Penn State Child Cohort. We extracted ORP in NREM sleep and in the 9s following cortical arousals (ORP-9) from 9-hour, in-lab polysomnography (PSG), and frequency and time-domain HRV indices from 24-h Holter EKG monitoring immediately following PSG. We stratified 24-h HRV data into daytime and nighttime periods. Linear regression analyses examined the associations between change in ORP and ORP-9 with adolescent 24-h HRV indices, adjusting for age, race, sex, BMI, metabolic syndrome score, AHI, insomnia symptoms, actigraphy-TST, and childhood nighttime HRV indices. Results While there were no significant associations between ORP and HRV indices in childhood, there were significant longitudinal and cross-sectional associations in adolescence. Longitudinally, a greater increase in ORP since childhood was associated with lower nighttime Log-LF and SDNN in adolescence (both P & lt; 0.05). Similar longitudinal associations were found for ORP-9, with the addition of higher daytime HR and lower daytime SDNN and RMSSD (all P & lt; 0.05). Cross-sectionally, higher ORP and ORP-9 were associated with higher 24-h HR, yet lower Log-LF, SDNN or RMSSD, for both daytime and nighttime periods in adolescence (all P & lt; 0.05). Conclusion Greater developmental declines in sleep depth and increases in arousability during NREM sleep are associated with impaired cardiac autonomic balance in adolescence, independent of sleep apnea, insomnia or insufficient sleep. These data also suggest a coupling between fine-grain spectral measures of the sleeping brain and those of sympathetic/parasympathetic cardiac modulation, which may inform cardiovascular risk early in life. Support (if any) NIH (R01HL136587, R01MH118308, UL1TR000127)
    Type of Medium: Online Resource
    ISSN: 0161-8105 , 1550-9109
    URL: Article
    DOI: 10.1093/sleep/zsad077.0747
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2023
    detail.hit.zdb_id: 2056761-3
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 4
    Online Resource
    Online Resource
    0758 Natural History of Insomnia Symptoms from Childhood through Adolescence into Young Adulthood: The Penn State Child Cohort
    Oxford University Press (OUP) ; 2019
    In:  Sleep Vol. 42, No. Supplement_1 ( 2019-04-13), p. A304-A305
    Details
    In: Sleep, Oxford University Press (OUP), Vol. 42, No. Supplement_1 ( 2019-04-13), p. A304-A305
    Type of Medium: Online Resource
    ISSN: 0161-8105 , 1550-9109
    URL: Article
    DOI: 10.1093/sleep/zsz067.756
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2019
    detail.hit.zdb_id: 2056761-3
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 5
    Online Resource
    Online Resource
    Abstract MP26: Visceral Obesity and Systemic Inflammation Predict Sleep Disordered Breathing in Normal Weight, Never Obese Adolescents: A Longitudinal, Population-Based Study
    Ovid Technologies (Wolters Kluwer Health) ; 2019
    In:  Circulation Vol. 139, No. Suppl_1 ( 2019-03-05)
    Details
    In: Circulation, Ovid Technologies (Wolters Kluwer Health), Vol. 139, No. Suppl_1 ( 2019-03-05)
    Abstract: Introduction: Although obesity is a known risk factor for sleep disordered breathing (SDB), a significant proportion of children with SDB are not obese or overweight as per body mass index percentile (BMI%) for age-and-sex. It is unknown whether premorbid or concurrent adiposity phenotypes are associated with SDB in normal weight youth. Hypothesis: We hypothesize that central obesity is a predictor of apnea/hypopnea index (AHI) in adolescents who have been otherwise normal weight since childhood. Methods: We analyzed data from the Penn State Child Cohort (N=421), a random population-based sample of 8.7 (1.7) year old children followed-up as 17.0 (2.3) year old adolescents. Of these, 242 subjects (49.2% female, 18.2% minority) were classified as persistently normal weight based on BMI% 〈 85 at both baseline and follow-up. Neck, hip and waist circumference (WC) were measured and “central obesity” was defined as a WC%≥85 for age-and-sex at baseline. During the follow-up exam, android and gynoid distribution and subcutaneous (SAT) and visceral (VAT) adipose tissue composition were assessed via DEXA scan, while inflammatory biomarkers were assayed from a fasting blood sample. The AHI was obtained from 9-hour, in-lab polysomnography at baseline and follow-up. Multivariable linear regression models examined the association between adiposity and inflammation with AHI at follow-up while adjusting for sex, race, adenotonsillectomy, age and AHI at baseline. Results: The average AHI at baseline was 0.7 (0.9) events/hour and 2.3 (6.3) events/hour at follow-up. Unadjusted analyses showed that WC (β=0.159) and central obesity (β=0.227) at baseline, but not BMI%, neck or hip circumference, and VAT (β=0.307), IL-6 (β=0.245), SAT (β=0.235), CRP (β=0.222), and android distribution (β=0.195) at follow-up were significantly (P 〈 0.05) associated with a higher follow-up AHI. Multivariable-adjusted analyses showed that VAT (β=0.299), IL-6 (β=0.191), central obesity (β=0.185) and CRP (β=0.163) were independently associated with a higher follow-up AHI. Conclusions: This is the first study to demonstrate that central obesity in childhood is a strong predictor of SDB in adolescence, even in individuals who have been persistently normal weight since childhood as per BMI% standards. These data support the clinical utility of simple measures of central obesity in childhood (i.e., WC) as early surrogate markers of increased risk of future development of SDB in the transition to adolescence. Furthermore, our study demonstrates that increased visceral adiposity and systemic inflammation are strong correlates of adolescent SDB, which supports the clinical utility of these biomarkers in predicting the cardiometabolic risk associated with adolescent SDB.
    Type of Medium: Online Resource
    ISSN: 0009-7322 , 1524-4539
    URL: Article
    DOI: 10.1161/circ.139.suppl_1.MP26
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2019
    detail.hit.zdb_id: 1466401-X
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 6
    Online Resource
    Online Resource
    0106 Cognitive-Emotional Features of Insomnia Phenotypes Based on Objective Sleep Duration in Young Adults
    Oxford University Press (OUP) ; 2024
    In:  SLEEP Vol. 47, No. Supplement_1 ( 2024-04-20), p. A47-A47
    Details
    In: SLEEP, Oxford University Press (OUP), Vol. 47, No. Supplement_1 ( 2024-04-20), p. A47-A47
    Abstract: The association of insomnia with adverse mental health outcomes is well-established. Prior research has suggested that cognitive-emotional predisposition to mental health disorders is shared across insomnia phenotypes. However, no study to date has examined this association in insomnia phenotypes based on objective sleep duration in young adults. Methods We studied 270 young adults (median 25 years, 53% female, 24% racial/ethnic minority) from the Penn State Child Cohort who underwent a 9-hour polysomnography (PSG) recording, clinical history, and self-report surveys. Insomnia symptoms were defined as difficulties initiating or maintaining sleep, an insomnia diagnosis or complaint, and/or sleep medication use. PSG-measured short sleep duration was defined by the median of the sample (i.e., & lt; 7-h), identifying normal sleep duration (NSD), short sleep duration (SSD), insomnia with normal sleep duration (INSD) and insomnia with short sleep duration (ISSD). Participants completed the Ford Insomnia Response to Stress Test (FIRST), Arousal Predisposition Scale (APS), Personality Inventory for DSM-5 (PID-5-BF), Pre-Sleep Arousal Scale (PSAS), and Depression, Anxiety, and Stress Scale (DASS). A multivariate general linear model tested mean differences in cognitive-emotional outcomes across the four groups, while adjusting for sex, race/ethnicity, age, waist circumference, sleep apnea, cardiometabolic disorders, medication and substance use. Results Compared to NSD or SSD, both INSD and ISSD showed significantly higher FIRST (Ps & lt; 0.001), APS (Ps & lt; 0.05), PID-5-BF (Ps & lt; 0.01), PSAS (Ps & lt; 0.001), and DASS (Ps & lt; 0.05) scores, except in the PID-5-BF antagonism and disinhibition trait domains. SSD showed significantly higher FIRST scores compared to NSD (P & lt; 0.05), but no other significant differences were observed on any other scale between SSD and NSD. Conclusion Sleep reactivity, cognitive-emotional arousability, internalization, and negative affectivity are trait features of insomnia, which help perpetuate its chronicity and put all phenotypes at risk of adverse mental health outcomes. These data also suggest that sleep reactivity may be a trait present in a subset of short sleepers at risk of developing insomnia. Support (if any) NIH (R01 HL136587, R01 MH118308, UL1 TR00127)
    Type of Medium: Online Resource
    ISSN: 0161-8105 , 1550-9109
    URL: Article
    DOI: 10.1093/sleep/zsae067.0106
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2024
    detail.hit.zdb_id: 2056761-3
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 7
    Online Resource
    Online Resource
    0393 Insomnia with Short Sleep Duration Is Associated with Hypertension and Endothelial Dysfunction in Young Adults
    Oxford University Press (OUP) ; 2024
    In:  SLEEP Vol. 47, No. Supplement_1 ( 2024-04-20), p. A169-A169
    Details
    In: SLEEP, Oxford University Press (OUP), Vol. 47, No. Supplement_1 ( 2024-04-20), p. A169-A169
    Abstract: Prior studies have examined the association between insomnia with short sleep duration (ISSD) with hypertension in middle-aged adults. However, no study to date has examined its association with elevated blood pressure (eBP) and flow-mediated dilation (FMD) in young adults. Methods We studied 270 young adults (median 25y, 53% female, 24% racial/ethnic minority) from the Penn State Child Cohort who underwent a 9-hour polysomnography (PSG) recording and Doppler ultrasound to asses FMD. The average of three consecutive BP readings was used to calculate resting mean arterial pressure (MAP) in the evening and morning. eBP was defined as systolic BP ≥120 mmHg, diastolic BP ≥80 mmHg, hypertension diagnosis, and/or antihypertensive medication use. Insomnia symptoms were defined as difficulties initiating or maintaining sleep, insomnia diagnosis or complaint, and/or sleep medication use. PSG-measured short sleep duration was defined by the median of the sample (i.e., & lt; 7-h), identifying normal sleep duration (NSD), short sleep duration (SSD), insomnia with normal sleep duration (INSD) and ISSD. Multivariate general linear models tested mean differences in MAP and FMD across the four groups adjusting for sex, race/ethnicity, age, waist circumference, sleep apnea, cardiometabolic disorders, substance and medication use. A logistic regression model examined the association of the four groups with the presence of eBP, while accounting for the same covariables. Results Compared to NSD (84.6±1.2) or INSD (85.7±0.8), ISSD showed significantly higher evening MAP levels (88.0±0.8; p=0.022 and p=0.044, respectively), a finding replicated by morning MAP levels. Neither INSD (p=0.466) nor SSD (86.9±1.3; p=0.190) showed significantly elevated MAP levels compared to NSD. Similarly, ISSD (9.4±0.5; p=0.012), but not INSD (10.3±0.5; p=0.170) or SSD (10.3±0.7; p=0.257), showed significantly lower FMD levels compared to NSD (11.4±0.6). The odds of eBP were significantly increased in ISSD (OR=2.5, 95%CI=1.0-6.2; p=0.044), but not in INSD (OR=1.7, 95%CI=0.7-4.3; p=0.244) or SSD (OR=1.4, 95%CI=0.5-4.1; p=0.580), compared to NSD. Conclusion ISSD, but not INSD, is associated with hypertension and endothelial dysfunction in young adults. Clinical trials should examine whether improving insomnia symptoms and lengthening objective sleep duration in this phenotype may lead to favorable cardiovascular outcomes. Support (if any) NIH (R01HL136587, R01MH118308, UL1TR00127)
    Type of Medium: Online Resource
    ISSN: 0161-8105 , 1550-9109
    URL: Article
    DOI: 10.1093/sleep/zsae067.0393
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2024
    detail.hit.zdb_id: 2056761-3
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 8
    Online Resource
    Online Resource
    0810 Impact of Schooling on the Measurement of Multidimensional Sleep Health in Adolescence
    Oxford University Press (OUP) ; 2024
    In:  SLEEP Vol. 47, No. Supplement_1 ( 2024-04-20), p. A347-A347
    Details
    In: SLEEP, Oxford University Press (OUP), Vol. 47, No. Supplement_1 ( 2024-04-20), p. A347-A347
    Abstract: Multidimensional Sleep Health (MSH) is an emerging concept in sleep and circadian science that aims to capture the 24-hour experience of sleep and identify individuals in the population with good sleep health. While schooling is one of the most important contextual variables impacting adolescent sleep, little is known about how it impacts the measurement of MSH. In the present study, we examined differences in adolescent MSH while they were either in-school or on-break. Methods We studied 377 adolescents (16.4±2.3 yr; 46.4% female; 21.5% racial/ethnic minority) from the Penn State Child Cohort, a randomly-selected population-based sample, with 63% of the sample (n=236) in-school when sleep data were collected. We used the MSH RU-SATED framework – regularity, satisfaction, alertness, timing, efficiency, and duration – to derive a composite score of sleep health using actigraphy and self-reports. Results Adolescents in-school had a marginally (p=0.07) higher MSH score (3.12±1.2) than those on-break (2.87±1.4). Adolescents on-break were more likely to have optimal alertness (37.8% vs 31.8%, p & lt; 0.05) and duration (37.2% vs 61.5%, p & lt; 0.05), but less likely to have optimal timing (30.8% vs 61.8%, p & lt; 0.001) and efficiency (34.6% vs 50.9%, p & lt; 0.001) compared to those assessed while in-school. The differences observed in the timing and duration domains were driven by on-break adolescents mean sleep midpoint being more than an hour later than those in-school (4:42 am vs 3:36 am, p & lt; 0.001) and having a mean sleep efficiency slightly below the cut-off of 85% (84.3% vs 85.9%, p & lt; 0.05). Conclusion Accounting for contextual factors in adolescents, specifically whether they are attending school or not, is important for the measurement of MSH. Future work should derive cut-offs for optimal sleep health specific to adolescents as well as potentially include other timing dimensions beyond average sleep midpoint, such as social jetlag. Support (if any) NIH Awards Number R01HL136587, UL1TR000127
    Type of Medium: Online Resource
    ISSN: 0161-8105 , 1550-9109
    URL: Article
    DOI: 10.1093/sleep/zsae067.0810
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2024
    detail.hit.zdb_id: 2056761-3
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 9
    Online Resource
    Online Resource
    Circadian Misalignment Impacts the Association of Visceral Adiposity With Elevated Blood Pressure in Adolescents
    Ovid Technologies (Wolters Kluwer Health) ; 2023
    In:  Hypertension Vol. 80, No. 4 ( 2023-04), p. 861-871
    Details
    In: Hypertension, Ovid Technologies (Wolters Kluwer Health), Vol. 80, No. 4 ( 2023-04), p. 861-871
    Abstract: Although insufficient sleep has been shown to contribute to obesity-related elevated blood pressure, the circadian timing of sleep has emerged as a novel risk factor. We hypothesized that deviations in sleep midpoint, a measure of circadian timing of sleep, modify the association between visceral adiposity and elevated blood pressure in adolescents. Methods: We studied 303 subjects from the Penn State Child Cohort (16.2±2.2 years; 47.5% female; 21.5% racial/ethnic minority). Actigraphy-measured sleep duration, midpoint, variability, and regularity were calculated across a 7-night period. Visceral adipose tissue (VAT) was measured with dual-energy X-ray absorptiometry. Systolic blood pressure (SBP) and diastolic blood pressure levels were measured in the seated position. Multivariable linear regression models tested sleep midpoint and its regularity as effect modifiers of VAT on SBP/diastolic blood pressure levels, while adjusting for demographic and sleep covariables. These associations were also examined as a function of being in-school or on-break. Results: Significant interactions were found between VAT and sleep irregularity, but not sleep midpoint, on SBP ( P interaction=0.007) and diastolic blood pressure ( P interaction=0.022). Additionally, significant interactions were found between VAT and schooldays sleep midpoint on SBP ( P interaction=0.026) and diastolic blood pressure ( P interaction=0.043), whereas significant interactions were found between VAT and on-break weekdays sleep irregularity on SBP ( P interaction=0.034). Conclusions: A delayed and an irregular sleep midpoint during school and during free-days, respectively, increase the impact of VAT on elevated blood pressure in adolescents. These data suggest that deviations in the circadian timing of sleep contribute to the increased cardiovascular sequelae associated with obesity and that its distinct metrics require measurement under different entrainment conditions in adolescents.
    Type of Medium: Online Resource
    ISSN: 0194-911X , 1524-4563
    URL: Article
    DOI: 10.1161/HYPERTENSIONAHA.122.20398
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2023
    detail.hit.zdb_id: 2094210-2
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 10
    Online Resource
    Online Resource
    Abstract MP47: Sleep Disordered Breathing is Adversely Associated With Cardiac Autonomic Modulation in Adolescents
    Ovid Technologies (Wolters Kluwer Health) ; 2023
    In:  Circulation Vol. 147, No. Suppl_1 ( 2023-02-28)
    Details
    In: Circulation, Ovid Technologies (Wolters Kluwer Health), Vol. 147, No. Suppl_1 ( 2023-02-28)
    Abstract: Introduction: Sleep disordered breathing (SDB), as measured by the apnea/hypopnea index (AHI), is a known risk factor for cardiovascular disease (CVD) in adults. Although SDB is prevalent in pediatric populations, there has been less focus on SDB as a primary risk factor for CVD in youth. The recent AHA scientific statement on SDB and CVD in children and adolescents suggests that, in order to better understand the long-term CVD-related risk associated with SDB in youth, additional longitudinal studies incorporating noninvasive markers of CVD are needed. The current study aimed to fill this important gap. Hypothesis: We hypothesized that SDB is associated with decreased HRV in adolescents. Methods: We studied 421 subjects from the Penn State Child Cohort who were 8.7 (1.7) years old at baseline and were followed-up as adolescents 16.5 (2.3) years old. We estimated the AHI from 9-hour, in-lab polysomnography (PSG), and frequency and time-domain heart rate variability (HRV) indices from 24-h Holter EKG monitoring immediately following PSG. We stratified 24-h HRV data into daytime and nighttime periods. Linear regression analyses examined the association between AHI with 24-h HRV indices, while adjusting for age, sex, race/ethnicity, BMI percentile, and metabolic syndrome (MetS) score in adolescence as well as AHI and nighttime HRV indices in childhood. Results: While there were no significant associations between AHI and daytime (p=0.233) or nighttime (p=0.147) HR, there were significant associations with frequency and time-domain HRV indices. A higher AHI was associated with lower Log-HF, Log-LF, SDNN and RMSSD, yet higher LF/HF, for both daytime and nighttime periods (all p 〈 0.05). For example, for each additional apnea or hypopnea per hour of sleep there was a decrease of -1.74ms (0.73) and -1.65ms (0.77) in SDNN during the daytime (p=0.018) and nighttime (p=0.033), respectively, even after adjusting for all covariates including MetS, childhood AHI and SDNN. More specifically, the 24-h SDNN of adolescents with an AHI≥5, indicative of moderate-to-severe SDB, was 10.9ms (4.4) lower than that of adolescents with an AHI=0 (p=0.014). Conclusions: SDB is associated with impaired cardiac autonomic balance in adolescence independently of MetS, prior SDB and prior HRV status. These data further support the role of SDB as an independent risk factor for CVD early in life.
    Type of Medium: Online Resource
    ISSN: 0009-7322 , 1524-4539
    URL: Article
    DOI: 10.1161/circ.147.suppl_1.MP47
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2023
    detail.hit.zdb_id: 1466401-X
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...