In:
Clinical Chemistry and Laboratory Medicine (CCLM), Walter de Gruyter GmbH, Vol. 50, No. 2 ( 2012-01-1)
Abstract:
α-Thalassemia is one of the most commonly inherited single-gene disorders in southern China. It is important to identify non-deletional α-thalassemia in areas where α-thalassemia is prevalent, since non-deletional HbH disease ( An approach based on high-resolution melting (HRM) analysis was used. A total of 74 samples, including 54 abnormal α-chain samples and 20 control samples, were tested. All of the 54 samples with point mutations at the exons 1, 2 or 3 of the α-globin genes, including 33 non-deletional α-thalassemia, were successfully detected. HRM has the potential to become an efficient, rapid screening method for non-deletional α-thalassemia.
Type of Medium:
Online Resource
ISSN:
1437-4331
,
1434-6621
DOI:
10.1515/cclm.2011.759
Language:
Unknown
Publisher:
Walter de Gruyter GmbH
Publication Date:
2012
detail.hit.zdb_id:
1492732-9
SSG:
15,3
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