In:
Beilstein Journal of Nanotechnology, Beilstein Institut, Vol. 10 ( 2019-09-24), p. 1933-1942
Abstract:
Diosgenin (Di), a steroidal sapogenin derived from plants, has been shown to exert anticancer effects in preclinical studies. Using Di as a starting material, various Di derivatives were designed and synthesized, aiming to discover new steroid-based antitumor agents. In this work, we synthesized several Di derivatives and screened FZU-0021-194-P2 (P2), which showed more potent cytotoxic activities against human non-small-cell lung cancer A549 and PC9 cells. Considering that Di has a unique sterol structure similarly to cholesterol, P2 phytosomes (P2Ps) were prepared to further improve the water solubility of P2. The P2Ps exhibited a particle size of 53.6 ± 0.3 nm with oval shape and a zeta potential of −4.0 ± 0.7 mV. P2Ps could inhibit the proliferation of lung cancer cells more efficiently than Di phytosomes after 72 h of incubation time by inducing cell cycle arrest and apoptosis. The results indicated that P2Ps could be a promising anticancer formulation for non-small-cell lung cancer.
Type of Medium:
Online Resource
ISSN:
2190-4286
DOI:
10.3762/bjnano.10.189
Language:
English
Publisher:
Beilstein Institut
Publication Date:
2019
detail.hit.zdb_id:
2583584-1
Permalink
