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  • Frontiers Media SA  (3)
  • Li, Zhiwei  (3)
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  • Frontiers Media SA  (3)
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  • 1
    Online Resource
    Online Resource
    Frontiers Media SA ; 2019
    In:  Frontiers in Immunology Vol. 10 ( 2019-8-13)
    In: Frontiers in Immunology, Frontiers Media SA, Vol. 10 ( 2019-8-13)
    Type of Medium: Online Resource
    ISSN: 1664-3224
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2019
    detail.hit.zdb_id: 2606827-8
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  • 2
    Online Resource
    Online Resource
    Frontiers Media SA ; 2022
    In:  Frontiers in Immunology Vol. 13 ( 2022-9-21)
    In: Frontiers in Immunology, Frontiers Media SA, Vol. 13 ( 2022-9-21)
    Abstract: The specific efficacy of immunotherapy for patients with liver metastases of gastric cancer is unclear. This study set out to explore the treatment response and related prognostic factors for patients with liver metastases of gastric cancer treated with immunotherapy. Patients and methods This retrospective cohort study included 135 patients with unresectable advanced gastric cancer. According to the presence of liver metastases and/or first-line treatment with immunotherapy, patients were divided into the following three groups: I-LM(-) group(patients without liver metastases treated with immunotherapy, n=66), I-LM(+) group(patients with liver metastases treated with immunotherapy, n=36), C-LM(+) group(patients with liver metastases treated with chemotherapy and/or target therapy, n=33). Cox regression analyses were used to identify factors associated with survival in all patients and the three groups, respectively. Results For the patients with liver metastases treated with immunotherapy, multivariate analysis showed that only the presence of peritoneal metastases was significantly associated with shorter PFS [hazard ratios (HR), 3.23; 95% CI, 1.12-9.32; P=0.030] and the patients with peritoneal metastases had shorter median PFS than patients without peritoneal metastases(3.1 vs 18.4 months; P=0.004), while the objective response rate was 100% in patients with HER2-positive (2 complete radiographic responses and 2 partial responses; 3 of 4 patients were still ongoing benefits [median follow-up time, 15.3 months ; interquartile range(IQR), 6.3-17.9 months] ). Conclusions The findings suggest that patients with various types of gastric cancer liver metastases respond differently to immune checkpoint inhibitors, HER2-positive patients may derive clinical benefits from immune checkpoint inhibitors, while the presence of peritoneal metastases is associated with resistance.
    Type of Medium: Online Resource
    ISSN: 1664-3224
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2606827-8
    Location Call Number Limitation Availability
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  • 3
    Online Resource
    Online Resource
    Frontiers Media SA ; 2021
    In:  Frontiers in Neuroscience Vol. 15 ( 2021-3-26)
    In: Frontiers in Neuroscience, Frontiers Media SA, Vol. 15 ( 2021-3-26)
    Abstract: The memristor-based convolutional neural network (CNN) gives full play to the advantages of memristive devices, such as low power consumption, high integration density, and strong network recognition capability. Consequently, it is very suitable for building a wearable embedded application system and has broad application prospects in image classification, speech recognition, and other fields. However, limited by the manufacturing process of memristive devices, high-precision weight devices are currently difficult to be applied in large-scale. In the same time, high-precision neuron activation function also further increases the complexity of network hardware implementation. In response to this, this paper proposes a configurable full-binary convolutional neural network (CFB-CNN) architecture, whose inputs, weights, and neurons are all binary values. The neurons are proportionally configured to two modes for different non-ideal situations. The architecture performance is verified based on the MNIST data set, and the influence of device yield and resistance fluctuations under different neuron configurations on network performance is also analyzed. The results show that the recognition accuracy of the 2-layer network is about 98.2%. When the yield rate is about 64% and the hidden neuron mode is configured as −1 and +1, namely ±1 MD, the CFB-CNN architecture achieves about 91.28% recognition accuracy. Whereas the resistance variation is about 26% and the hidden neuron mode configuration is 0 and 1, namely 01 MD, the CFB-CNN architecture gains about 93.43% recognition accuracy. Furthermore, memristors have been demonstrated as one of the most promising devices in neuromorphic computing for its synaptic plasticity. Therefore, the CFB-CNN architecture based on memristor is SNN-compatible, which is verified using the number of pulses to encode pixel values in this paper.
    Type of Medium: Online Resource
    ISSN: 1662-453X
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2021
    detail.hit.zdb_id: 2411902-7
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