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  • Hindawi Limited  (72)
  • Li, Yun  (72)
  • 1
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    Online Resource
    Social App to Improve Warfarin Therapy in Post-MHVR Chinese Patients: A Randomized Controlled Trial
    Hindawi Limited ; 2023
    In:  Cardiovascular Therapeutics Vol. 2023 ( 2023-1-14), p. 1-10
    Details
    In: Cardiovascular Therapeutics, Hindawi Limited, Vol. 2023 ( 2023-1-14), p. 1-10
    Abstract: Background. Poor anticoagulation quality was a major problem among warfarin-treated patients, which called for innovative and effective methods to improve it. Objective. To investigate whether social app could be used to reduce warfarin-associated adverse events among post-MHVR Chinese patients. Method. 735 warfarin-treated patients ( aged   50.8 ± 9.6   years , 59.9% female) were enrolled and randomized to a social app care group (warfarin therapy was guided by experienced clinicians via a social app) or a routine care group (warfarin therapy was managed through traditional in-office visits) at a 1 : 1 ratio. Ending points (bleeding and thrombotic events) were recorded during an 18-month follow-up period. Results. A total of 718 patients were included in analysis. 57 of them suffered warfarin-associated adverse events, including 30 major bleedings and 27 thrombotic events. The time in the therapeutic range (TTR, Rosendaal method) in the social app group was 71.5%, which was significantly better than 52.6% in the routine care group (difference: 18.8%, 95% CI: 16.8-20.8). Compared with the patients from the social app group, patients under routine care experienced more bleeding (hazard ratio (HR): 2.31, 95% CI: 1.13-4.72). The social app care group had lower variation (0.55 vs. 0.70) in the international normalized ratio (INR) values and fewer incidents of extremely high INR (e.g., INR 〉 5.0 , 0.87% vs. 3.42%) than the routine care group. Conclusions. Social app management could significantly improve warfarin control and was associated with a reduction in bleeding risk. This trial was registered with NCT03264937.
    Type of Medium: Online Resource
    ISSN: 1755-5922 , 1755-5914
    URL: Article
    DOI: 10.1155/2023/2342111
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2023
    detail.hit.zdb_id: 2417088-4
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  • 2
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    Circulating Betatrophin in Patients with Type 2 Diabetes: A Meta-Analysis
    Hindawi Limited ; 2016
    In:  Journal of Diabetes Research Vol. 2016 ( 2016), p. 1-9
    Details
    In: Journal of Diabetes Research, Hindawi Limited, Vol. 2016 ( 2016), p. 1-9
    Abstract: Objective . To investigate the association between circulating betatrophin level and type 2 diabetes mellitus (T2DM) in human. Methods . A comprehensive literature search was performed in PubMed and Embase databases to identify eligible studies assessing the circulating levels of betatrophin in both T2DM patients and nondiabetic adults. Results . A total of nine eligible studies with twelve comparisons were included for the final meta-analysis. Circulating betatrophin levels in T2DM patients were higher than those in the nondiabetic controls (random-effect SMD 0.53; 95% CI 0.13 to 0.94; P = 0.010 ). In the subgroup of nonobese population but not the obese population, the overall betatrophin level in T2DM patients was much higher than that in the nondiabetic controls (nonobese: random-effect SMD, 0.82; 95% CI 0.42 to 1.21; P 〈 0.001 ; obese: random-effect SMD, −0.39; 95% CI, −0.95 to 0.18; P = 0.18 ). Metaregression indicated that body mass index of T2DM patients was associated with mean difference of betatrophin level between T2DM and nondiabetic adults (slope, −578.8; t = - 2.7 ; P = 0.02 ). Conclusion. Based on the findings of our meta-analysis, circulating betatrophin level of T2DM patients is higher than that of nondiabetic adults in the nonobese population, but not in the obese population.
    Type of Medium: Online Resource
    ISSN: 2314-6745 , 2314-6753
    URL: Article
    DOI: 10.1155/2016/6194750
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2016
    detail.hit.zdb_id: 2711897-6
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  • 3
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    Deep Federated Learning Based Convergence Analysis in Relaying-Aided MEC-IoT Networks
    Hindawi Limited ; 2022
    In:  Journal of Engineering Vol. 2022 ( 2022-9-28), p. 1-6
    Details
    In: Journal of Engineering, Hindawi Limited, Vol. 2022 ( 2022-9-28), p. 1-6
    Abstract: Recently, deep federated learning has attracted much attention from researchers in the fields of wireless communications, where the relaying technique has been shown as a powerful technology to assist the wireless signals and enhance the transmission quality, which is very important to the development of mobile edge computing (MEC) based Internet of Things (IoT) networks. In a relaying-aided MEC-IoT system, it is of vital importance to deeply investigate the system signal-to-noise ratio (SNR) at the receiver side, as it mainly determines the system performance metrics, such as capacity (or achievable data rate), outage probability, and bit-error-rate (BER). To this end, we first investigate the instantaneous convergence error, by deeply studying the relationship between the instantaneous two-hop relaying channels. We then investigate the statistical convergence error, by performing the statistical expectation with respect to the two-hop relaying channels. We finally present some results to show that the analysis of the convergence error is effective. The work in this paper can provide some theoretical foundation for deep federated learning and computing networks.
    Type of Medium: Online Resource
    ISSN: 2314-4912 , 2314-4904
    URL: Article
    DOI: 10.1155/2022/8425975
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2736230-9
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  • 4
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    GRP78 Promotes Neural Stem Cell Antiapoptosis and Survival in Response to Oxygen-Glucose Deprivation (OGD)/Reoxygenation through PI3K/Akt, ERK1/2, and NF- κ B/p65 Pathways
    Hindawi Limited ; 2018
    In:  Oxidative Medicine and Cellular Longevity Vol. 2018 ( 2018), p. 1-12
    Details
    In: Oxidative Medicine and Cellular Longevity, Hindawi Limited, Vol. 2018 ( 2018), p. 1-12
    Abstract: When brain injury happens, endogenous neural stem cells (NSCs) located in the adult subventricular zone (SVZ) and subgranular zone (SGZ) are attacked by ischemia/reperfusion to undergo cellular apoptosis and death before being induced to migrate to the lesion point and differentiate into mature neural cells for damaged cell replacement. Although promoting antiapoptosis and NSC survival are critical to neuroregeneration, the mechanism has yet been elucidated clearly. Here in this study, we established an in vitro oxygen-glucose deprivation (OGD)/reoxygenation model on NSCs and detected glucose-regulated protein 78 (GRP78) involved in apoptosis, while in the absence of GRP78 by siRNA transfection, OGD/reoxygenation triggered PI3K/Akt, ERK1/2, and NF- κ B/p65 activation, and induced NSC apoptosis was attenuated. Further investigation, respectively, with the inhibitor of PI3K/Akt or ERK1/2 demonstrated a blockage on GRP78 upregulation, while the inhibition of NF- κ B rarely affected GRP78 induction by OGD/reoxygenation. The results indicated the bidirectional regulations of GRP78-PI3K/Akt and GRP78-ERK1/2 and the one-way signalling transduction through GRP78 to NF- κ B/p65 on NSC survival from OGD/reoxygenation. In conclusion, we found that GRP78 mediated the signalling cross talk through PI3K/Akt, ERK1/2, and NF- κ B/p65, which leads to antiapoptosis and NSC survival from ischemic stroke. Our finding gives a new evidence of GRP78 in NSCs as well as a new piece of signalling mechanism elucidation to NSC survival from ischemic stroke.
    Type of Medium: Online Resource
    ISSN: 1942-0900 , 1942-0994
    URL: Article
    DOI: 10.1155/2018/3541807
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2018
    detail.hit.zdb_id: 2455981-7
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  • 5
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    Fabrication and Spectral Properties of Wood-Based Luminescent Nanocomposites
    Hindawi Limited ; 2014
    In:  Journal of Nanomaterials Vol. 2014 ( 2014), p. 1-4
    Details
    In: Journal of Nanomaterials, Hindawi Limited, Vol. 2014 ( 2014), p. 1-4
    Abstract: Pressure impregnation pretreatment is a conventional method to fabricate wood-based nanocomposites. In this paper, the wood-based luminescent nanocomposites were fabricated with the method and its spectral properties were investigated. The results show that it is feasible to fabricate wood-based luminescent nanocomposites using microwave modified wood and nanophosphor powders. The luminescent strength is in positive correlation with the amount of phosphor powders dispersed in urea-formaldehyde resin. Phosphors absorb UV and blue light efficiently in the range of 400–470 nm and show a broad band of bluish-green emission centered at 500 nm, which makes them good candidates for potential blue-green luminescent materials.
    Type of Medium: Online Resource
    ISSN: 1687-4110 , 1687-4129
    URL: Article
    DOI: 10.1155/2014/361457
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2014
    detail.hit.zdb_id: 2229480-6
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  • 6
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    Inhibition of HSP90 Promotes Neural Stem Cell Survival from Oxidative Stress through Attenuating NF- κ B/p65 Activation
    Hindawi Limited ; 2016
    In:  Oxidative Medicine and Cellular Longevity Vol. 2016 ( 2016), p. 1-10
    Details
    In: Oxidative Medicine and Cellular Longevity, Hindawi Limited, Vol. 2016 ( 2016), p. 1-10
    Abstract: Stem cell survival after transplantation determines the efficiency of stem cell treatment, which develops as a novel potential therapy for several central nervous system (CNS) diseases in recent decades. The engrafted stem cells face the damage of oxidative stress, inflammation, and immune response at the lesion point in host. Among the damaging pathologies, oxidative stress directs stem cells to apoptosis and even death through several signalling pathways and DNA damage. However, the in-detail mechanism of stem cell survival from oxidative stress has not been revealed clearly. Here, in this study, we used hydrogen peroxide (H 2 O 2 ) to induce the oxidative damage on neural stem cells (NSCs). The damage was in consequence demonstrated involving the activation of heat shock protein 90 (HSP90) and NF- κ B/p65 signalling pathways. Further application of the pharmacological inhibitors, respectively, targeting at each signalling indicated an upper-stream role of HSP90 upon NF- κ B/p65 on NSCs survival. Preinhibition of HSP90 with the specific inhibitor displayed a significant protection on NSCs against oxidative stress. In conclusion, inhibition of HSP90 would attenuate NF- κ B/p65 activation by oxidative induction and promote NSCs survival from oxidative damage. The HSP90/NF- κ B mechanism provides a new evidence on rescuing NSCs from oxidative stress and also promotes the stem cell application on CNS pathologies.
    Type of Medium: Online Resource
    ISSN: 1942-0900 , 1942-0994
    URL: Article
    DOI: 10.1155/2016/3507290
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2016
    detail.hit.zdb_id: 2455981-7
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  • 7
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    Feasibility of Terahertz Time-Domain Spectroscopy to Detect Carbendazim Mixtures Wrapped in Paper
    Hindawi Limited ; 2017
    In:  Journal of Spectroscopy Vol. 2017 ( 2017), p. 1-8
    Details
    In: Journal of Spectroscopy, Hindawi Limited, Vol. 2017 ( 2017), p. 1-8
    Abstract: The purpose of this work was to detect carbendazim mixtures wrapped in paper. Unlike previous reports of THz-TDS for detecting pesticide residue, this work focused on detecting pesticide residue in packaged foods. Different weight ratios of carbendazim in polyethylene and in rice powder were detected qualitatively and quantitatively. Results show that pure carbendazim, polyethylene, and rice powder can be easily distinguished from each other. However, when the weight ratio was low, the absorbance of the mixture was similar with that of pure polyethylene and rice powder. With the help of SVM, carbendazim could be qualitatively detected in low weight ratio mixture successfully. Moreover, PLS and SVR were selected to quantitatively detect carbendazim mixtures. SVR has higher R and lower RMSECV, RMSEC, and RMSEP than PLS model. Lasty, the results also indicate that THz-TDS is a potential tool to detect pesticide residue in packaged foods qualitatively and quantitatively.
    Type of Medium: Online Resource
    ISSN: 2314-4920 , 2314-4939
    URL: Article
    DOI: 10.1155/2017/6302868
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2017
    detail.hit.zdb_id: 2068433-2
    SSG: 11
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  • 8
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    Compound Phyllanthus urinaria L Inhibits HBV-Related HCC through HBx-SHH Pathway Axis Inactivation
    Hindawi Limited ; 2019
    In:  Evidence-Based Complementary and Alternative Medicine Vol. 2019 ( 2019-03-24), p. 1-15
    Details
    In: Evidence-Based Complementary and Alternative Medicine, Hindawi Limited, Vol. 2019 ( 2019-03-24), p. 1-15
    Abstract: Compound Phyllanthus urinaria L (CP) is a traditional formula widely used in clinical practice for hepatocellular carcinoma (HCC), especially HBV-related HCC. HBx, HBV X gene encoded X protein, has positive correlation with the abnormal SHH pathway in HBV-related HCC. So, we predicted that CP has the capability of anti-HBV-related HCC maybe via inactivating the HBx-Hedgehog pathway axis. HepG2-HBx cells, HBx overexpression, were treated with CP (70 μ g/ml and 35  μ g/ml, respectively) for 48 hours and the mice which received the HepG2-HBx cells were treated with CP (625mg/kg and 300 mg/kg, respectively) for 17 days to evaluate the effect of CP on HBV-related HCC. HBx could accelerate HepG2 cells proliferation, clone formation, and migration in vitro and also could strengthen tumor growth in mice. However, CP could significantly decrease HepG2-HBx cells proliferation, clone formation, and migration in vitro and also could inhibit tumors growth in mice in a dose-dependent manner. Mechanism studies suggested that HBx upregulated the mRNA and proteins expression of Sonic hedgehog (SHH), transmembrane receptor patched (PTCH-1), smoothened (SMO), oncogene homolog transcription factors-1 (GLI-1), and oncogene homolog transcription factors-2 (GLI-2), which are compositions of the SHH pathway. CP could inhibit the mRNA and proteins expression of SHH, PTCH-1, GLI-1, and HBx. It may be one of the underlying mechanisms of CP to delay the HBV-related HCC development through the HBx-SHH pathway axis inactivation.
    Type of Medium: Online Resource
    ISSN: 1741-427X , 1741-4288
    URL: Article
    DOI: 10.1155/2019/1635837
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2019
    detail.hit.zdb_id: 2148302-4
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  • 9
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    Energy Theft Detection in an Edge Data Center Using Deep Learning
    Hindawi Limited ; 2021
    In:  Mathematical Problems in Engineering Vol. 2021 ( 2021-7-8), p. 1-12
    Details
    In: Mathematical Problems in Engineering, Hindawi Limited, Vol. 2021 ( 2021-7-8), p. 1-12
    Abstract: With the development of smart grid information physical systems, some of the data processing functions gradually approach the edge layer of end-users. To better realize the energy theft detection function at the edge, we proposed an energy theft detection method based on the power consumption information acquisition system of power enterprises. The method involves the following steps. In the centralized data center, K-means is used to decompose a large amount of data into small data and then input and train neural network parameters to realize feature extraction. We design a neural network named DWMCNN, which can extract features from the day, week, and month and can extract more accurate features. In the edge data center, the random forest (RF) algorithm is used to classify the extracted features. The experimental results show that the clustering method accords with the idea of edge computing-distributed processing and improves the operation speed and that the feature extractor has good convergence performance. In addition, compared with the methods based on various classifiers, this method has higher accuracy and lower computational complexity, which is suitable for the deployment of edge data centers.
    Type of Medium: Online Resource
    ISSN: 1563-5147 , 1024-123X
    URL: Article
    DOI: 10.1155/2021/9938475
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2014442-8
    SSG: 11
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  • 10
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    Numerical Simulation on the Effect of Turbulence Models on Impingement Cooling of Double Chamber Model
    Hindawi Limited ; 2013
    In:  Mathematical Problems in Engineering Vol. 2013 ( 2013), p. 1-8
    Details
    In: Mathematical Problems in Engineering, Hindawi Limited, Vol. 2013 ( 2013), p. 1-8
    Abstract: Investigation of the effects of impingement cooling for the different turbulence models and study of the aerodynamic behavior of a simplified transition piece model (TP) are the two themes of this paper. A model (double chamber model) of a one-fourth cylinder is designed which could simulate the transition piece structure and performance. The relative strengths and drawbacks of renormalization group theory k - ε (RNG), the realizable k - ε (RKE), the v 2 - f , the shear stress transport k - ω (SST), and large-eddy simulation (LES) models are used to solve the closure problem. The prediction of the inner wall temperature, cooling effectiveness, and velocity magnitude contours in various conditions are compared in five different turbulence models. Surprisingly, the v 2 - f and SST models can produce even better predictions of fluid properties in impinging jet flows. It is recommended as the best compromise between solution speed and accuracy.
    Type of Medium: Online Resource
    ISSN: 1024-123X , 1563-5147
    URL: Article
    DOI: 10.1155/2013/170317
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2013
    detail.hit.zdb_id: 2014442-8
    SSG: 11
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