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  • SAGE Publications  (65)
  • Li, Yu  (65)
  • 1
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    Online Resource
    Traditional Herbal Medicine: A Potential Therapeutic Approach for Adjuvant Treatment of Non-small Cell Lung Cancer in the Future
    SAGE Publications ; 2022
    In:  Integrative Cancer Therapies Vol. 21 ( 2022-01), p. 153473542211443-
    Details
    In: Integrative Cancer Therapies, SAGE Publications, Vol. 21 ( 2022-01), p. 153473542211443-
    Abstract: Lung carcinoma is the primary reason for cancer-associated mortality, and it exhibits the highest mortality and incidence in developed and developing countries. Non-small cell lung cancer (NSCLC) and SCLC are the 2 main types of lung cancer, with NSCLC contributing to 85% of all lung carcinoma cases. Conventional treatment mainly involves surgery, chemoradiotherapy, and immunotherapy, but has a dismal prognosis for many patients. Therefore, identifying an effective adjuvant therapy is urgent. Historically, traditional herbal medicine has been an essential part of complementary and alternative medicine, due to its numerous targets, few side effects and substantial therapeutic benefits. In China and other East Asian countries, traditional herbal medicine is increasingly popular, and is highly accepted by patients as a clinical adjuvant therapy. Numerous studies have reported that herbal extracts and prescription medications are effective at combating tumors. It emphasizes that, by mainly regulating the P13K/AKT signaling pathway, the Wnt signaling pathway, and the NF-κB signaling pathway, herbal medicine induces apoptosis and inhibits the proliferation and migration of tumor cells. The present review discusses the anti-NSCLC mechanisms of herbal medicines and provides options for future adjuvant therapy in patients with NSCLC.
    Type of Medium: Online Resource
    ISSN: 1534-7354 , 1552-695X
    URL: Article
    DOI: 10.1177/15347354221144312
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2101248-9
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  • 2
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    Extracellular Vesicles Derived From Hypoxia-Conditioned Adipose-Derived Mesenchymal Stem Cells Enhance Lymphangiogenesis
    SAGE Publications ; 2022
    In:  Cell Transplantation Vol. 31 ( 2022-01), p. 096368972211075-
    Details
    In: Cell Transplantation, SAGE Publications, Vol. 31 ( 2022-01), p. 096368972211075-
    Abstract: Extracellular vesicles from adipose-derived mesenchymal stem cells (ADSCs) play an important role in lymphangiogenesis; however, the underlying mechanisms are not fully understood. In this study, we aimed to investigate the function of extracellular vesicles secreted by hypoxia-conditioned ADSCs in lymphangiogenesis and explore the potential molecular mechanisms. Extracellular vesicles were extracted from ADSCs cultured under hypoxia or normoxia conditions. The uptake of extracellular vesicles by lymphatic endothelial cells (LECs) was detected by immunofluorescence staining. The effects of extracellular vesicles on the viability, migration, and tube formation of LECs were determined by CCK-8 assay, migration assay, and tube formation assay, respectively. Molecules and pathway involved in lymphangiogenesis mediated by ADSC-derived extracellular vesicles were analyzed by luciferase reporter assay, qRT-polymerase chain reaction (PCR), and Western blot. Hypoxia ADSC-derived extracellular vesicles (H-ADSC/evs) significantly enhanced the proliferation, migration, and tube formation of LECs. Hypoxia decreased the expression of miR-129 in ADSC-derived extracellular vesicles. Overexpression of miR-129 counteracted the promoting effect of H-ADSC/evs on lymphangiogenesis. In addition, decreased exosomal miR-129 expression resulted in upregulation of HMGB1 in LECs, which led to AKT activation and lymphangiogenesis enhancement. Our data reveal that extracellular vesicles derived from hypoxia-conditioned ADSCs induce lymphangiogenesis, and this effect is mediated by miR-129/HMGB1/AKT signaling. Our findings imply that hypoxia ADSC-isolated extracellular vesicles may represent as a valuable target for the treatment of diseases associated with lymphatic remodeling.
    Type of Medium: Online Resource
    ISSN: 0963-6897 , 1555-3892
    URL: Article
    DOI: 10.1177/09636897221107536
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2020466-8
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  • 3
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    Quantitative evaluation of wetness losses in steam turbines based on three-dimensional simulations of non-equilibrium condensing flows
    SAGE Publications ; 2014
    In:  Proceedings of the Institution of Mechanical Engineers, Part A: Journal of Power and Energy Vol. 228, No. 6 ( 2014-09), p. 708-716
    Details
    In: Proceedings of the Institution of Mechanical Engineers, Part A: Journal of Power and Energy, SAGE Publications, Vol. 228, No. 6 ( 2014-09), p. 708-716
    Abstract: Wet steam flow in steam turbines leads to degraded efficiency and blade erosion in the turbine stages. The Baumann rule, which has been used to predict wetness losses, is increasingly being questioned. More recently, the non-equilibrium condensation model is being increasingly applied to analyse wet steam flow. However, most of the influences caused by wetness losses on the aerodynamics of a wet steam turbine are excluded when this approach is used. Therefore, the efficiency of a wet steam turbine calculated by the non-equilibrium approach does not match the experimentally obtained values. To improve the accuracy of evaluating a wet steam turbine as well as the wetness losses, a quantitative evaluation program of wetness losses has been developed based on the calculation results of wet steam flow with non-equilibrium condensation using the FORTRAN language. Three-dimensional (3D) simulation of the wet steam flow with non-equilibrium condensation in turbine stages is first conducted. Then the 3D results are circumferentially averaged in the meridian plane, which are subsequently used to quantitatively evaluate the wetness losses. The wetness losses are divided into five categories: thermodynamic loss, droplet drag loss, braking loss, capturing loss and centrifuge loss. The wetness losses in the low pressure (LP) cylinder of a fossil steam turbine are calculated. The results show that the thermodynamic loss is mainly generated in the nucleation stage and the last stage of the turbine where non-equilibrium condensation occurs. The droplet drag loss is small in all wet steam stages. The braking loss is the most important component of the wetness losses, except in the nucleation stage. The capturing and centrifuge losses are moderate in the wet steam stages. The total wetness losses in the LP cylinder account for 3.65% of the total output power. This is less than the 5.14% losses predicted by the Baumann rule.
    Type of Medium: Online Resource
    ISSN: 0957-6509 , 2041-2967
    URL: Article
    DOI: 10.1177/0957650914534838
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2014
    detail.hit.zdb_id: 2024892-1
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  • 4
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    Sodium and Potassium Released from Burning Particles of Brown Coal and Pine Wood in a Laminar Premixed Methane Flame Using Quantitative Laser-Induced Breakdown Spectroscopy
    SAGE Publications ; 2011
    In:  Applied Spectroscopy Vol. 65, No. 6 ( 2011-06), p. 684-691
    Details
    In: Applied Spectroscopy, SAGE Publications, Vol. 65, No. 6 ( 2011-06), p. 684-691
    Abstract: A quantitative point measurement of total sodium ([Na] total ) and potassium ([K] total ) in the plume of a burning particle of Australian Loy Yang brown coal (23 ± 3 mg) and of pine wood pellets (63 ± 3 mg) was performed using laser-induced breakdown spectroscopy (LIBS) in a laminar premixed methane flame at equivalence ratios (Φ) of 1.149 and 1.336. Calibration was performed using atomic sodium or potassium generated by evaporation of droplets of sodium sulfite (Na 2 SO 3 ) or potassium sulfate (K 2 SO 4 ) solutions seeded into the flame. The calibration compensated for the absorption by atomic alkalis in the seeded flame, which is significant at high concentrations of solution. This allowed quantitative measurements of sodium (Na) and potassium (K) released into the flame during the three phases of combustion, namely devolatilization, char, and ash cooking. The [Na] total in the plume released from the combustion of pine wood pellets during the devolatilization was found to reach up to 13 ppm. The maximum concentration of total sodium ([Na] max total ) and potassium ([K] max total ) released during the char phase of burning coal particles for Φ = 1.149 was found to be 9.27 and 5.90 ppm, respectively. The [Na] max total and [K] max total released during the char phase of burning wood particles for Φ = 1.149 was found to be 15.1 and 45.3 ppm, respectively. For the case of Φ = 1.336, the [Na] max total and [K] max total were found to be 13.9 and 6.67 ppm during the char phase from burning coal particles, respectively, and 21.1 and 39.7 ppm, respectively, from burning wood particles. The concentration of alkali species was higher during the ash phase. The limit of detection (LOD) of sodium and potassium with LIBS in the present arrangement was estimated to be 29 and 72 ppb, respectively.
    Type of Medium: Online Resource
    ISSN: 0003-7028 , 1943-3530
    URL: Article
    DOI: 10.1366/10-06108
    RVK:
    VA 2367
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2011
    detail.hit.zdb_id: 1474251-2
    SSG: 11
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  • 5
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    Exploring the landscape, hot topics, and trends of bariatric metabolic surgery with machine learning and bibliometric analysis
    SAGE Publications ; 2022
    In:  Therapeutic Advances in Gastrointestinal Endoscopy Vol. 15 ( 2022-01), p. 263177452211119-
    Details
    In: Therapeutic Advances in Gastrointestinal Endoscopy, SAGE Publications, Vol. 15 ( 2022-01), p. 263177452211119-
    Abstract: This study aimed to analyze the landscape of publications on bariatric metabolic surgery through machine learning and help experts and scholars from various disciplines better understand bariatric metabolic surgery’s hot topics and trends. Methods: In January 2021, publications indexed in PubMed under the Medical Subject Headings (MeSH) term ‘Bariatric Surgery’ from 1946 to 2020 were downloaded. Python was used to extract publication dates, abstracts, and research topics from the metadata of publications for bibliometric evaluation. Descriptive statistical analysis, social network analysis (SNA), and topic modeling with latent Dirichlet allocation (LDA) were used to reveal bariatric metabolic surgery publication growth trends, landscape, and research topics. Results: A total of 21,798 records of bariatric metabolic surgery–related literature data were collected from PubMed. The number of publications indexed to bariatric metabolic surgery had expanded rapidly. Obesity Surgery and Surgery for Obesity and Related Diseases are currently the most published journals in bariatric metabolic surgery. The bariatric metabolic surgery research mainly included five topics: bariatric surgery intervention, clinical case management, basic research, body contour, and surgical risk study. Conclusion: Despite a rapid increase in bariatric metabolic surgery–related publications, few studies were still on quality of life, psychological status, and long-term follow-up. In addition, basic research has gradually increased, but the mechanism of bariatric metabolic surgery remains to be further studied. It is predicted that the above research fields may become potential hot topics in the future.
    Type of Medium: Online Resource
    ISSN: 2631-7745 , 2631-7745
    URL: Article
    DOI: 10.1177/26317745221111944
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 3011635-1
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  • 6
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    Mechanism of the Mitogen-Activated Protein Kinases/Mammalian Target of Rapamycin Pathway in the Process of Cartilage Endplate Stem Cell Degeneration Induced by Tension Load
    SAGE Publications ; 2023
    In:  Global Spine Journal Vol. 13, No. 8 ( 2023-10), p. 2396-2408
    Details
    In: Global Spine Journal, SAGE Publications, Vol. 13, No. 8 ( 2023-10), p. 2396-2408
    Abstract: Basic Research. Objective Intervertebral disc degeneration (IVDD) is caused by the cartilage endplate (CEP). Cartilage endplate stem cell (CESC) is involved in the recovery of CEP degeneration. Tension load (TL) contributes a lot to the initiation and progression of IVDD. This study aims to investigate the regulatory mechanism of the Mitogen-activated protein kinases/Mammalian target of rapamycin (MAPK/mTOR) pathway during TL-induced CESC degeneration. Methods CESCs were isolated from New Zealand big-eared white female rabbits (6 months old). FX-4000T cell stress loading system was applied to establish a TL-induced degeneration model of CESCs. Western blotting was used to detect the level of mTOR pathway-related proteins and autophagy markers LC3-Ⅱ, Beclin-1, and p62 in degenerative CESCs. The expression of MAPK pathway-related proteins JNK and extracellular signal-regulated kinases (ERK) in degenerated CESCs was inhibited by cell transfection to explore whether JNK and ERK play a regulatory role in TL-induced autophagy in CESCs. Results In the CESC degeneration model, the mTOR pathway was activated. After inhibition of mTOR, the autophagy level of CESCs was increased, and the degeneration of CESCs was alleviated. The MAPK pathway was also activated in the CESC degeneration model. Inhibition of JNK expression may alleviate TL-induced CEP degeneration by inhibiting Raptor phosphorylation and activating autophagy. Inhibition of ERK expression may alleviate TL-induced CEP degeneration by inhibiting mTOR phosphorylation and activating autophagy. Conclusion Inhibition of JNK and ERK in the MAPK signaling family alleviated TL-induced CESC degeneration by inhibiting the phosphorylation of Raptor and mTOR in the mTOR pathway.
    Type of Medium: Online Resource
    ISSN: 2192-5682 , 2192-5690
    URL: Article
    DOI: 10.1177/21925682221085226
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2648287-3
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  • 7
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    Study of manufacturing resource perception and process control of a radio-frequency-identification-enabled decentralized flexible manufacturing system
    SAGE Publications ; 2017
    In:  Advances in Mechanical Engineering Vol. 9, No. 1 ( 2017-01), p. 168781401668744-
    Details
    In: Advances in Mechanical Engineering, SAGE Publications, Vol. 9, No. 1 ( 2017-01), p. 168781401668744-
    Abstract: The fusion of mechatronics, communication, control, and information technologies has introduced new automation paradigms into the production environment. Plug-and-play flexible manufacturing systems will become suitable approaches in the future for the development of modular, flexible, and reconfigurable manufacturing systems, addressing the requirements of global markets. This article introduces a Petri Net model-driven methodology for the development, validation, and operation of a radio-frequency identification-enabled decentralized flexible manufacturing system. After analyzing the manufacturing processes and resources of a flexible manufacturing system, the manufacturing resources are classified into active and passive resources. Each active resource is equipped with a radio-frequency identification reader and each passive resource is banded with a radio-frequency identification tag. Real-time state and behavior logic models are built for manufacturing resources based on extended Petri Nets; the models are translated into XML and integrated with the manufacturing resources. In this fashion, each manufacturing resource becomes an autonomous agent, and it can make self-decisions and update its status through the twinned models. In this manner, automatic perception and process control are realized. Finally, the effectiveness and feasibility of the method are verified in an experimental system.
    Type of Medium: Online Resource
    ISSN: 1687-8140 , 1687-8140
    URL: Article
    DOI: 10.1177/1687814016687449
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2017
    detail.hit.zdb_id: 2501620-9
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  • 8
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    Simultaneous stable control of temperature field distribution uniformity and consistency for multi-temperature zone systems
    SAGE Publications ; 2021
    In:  Transactions of the Institute of Measurement and Control Vol. 43, No. 9 ( 2021-06), p. 2069-2080
    Details
    In: Transactions of the Institute of Measurement and Control, SAGE Publications, Vol. 43, No. 9 ( 2021-06), p. 2069-2080
    Abstract: As a key factor characterizing the control accuracy of multi-temperature zone systems (MTZSs), the stable control of temperature field distribution uniformity and consistency is of critical importance for MTZSs, and it largely determines the product quality and production efficiency. Due to the complicated multiple input and output properties, as well as the various external variations in practice, however, it is extremely difficult to monitor the temperature field distribution in production process. To address the uniform and consistent temperature field distribution problem in MTZSs, a multi-variable dynamic matrix control (DMC)-based predictive control mechanism is proposed in this paper. Specifically, we first establish a finite element-based heat transfer model to analyse heat transfer within the multi-temperature zone, and then propose a multi-variable DMC-based decoupling design method to decompose the entire system into multiple subsystems with single-input single-output for temperature uniformity distribution control in MTZS. By utilizing the ANSYS tools to analyse the transient field temperatures, we obtain both time and space distribution characteristics of the transient temperature field with the proposed control method, and also compare such results with those obtained using the PID control method. Finally, we apply the proposed multi-variable DMC control mechanism onto a multi-temperature sintering furnace of a practical industrial product line for verification. Results show that, with the proposed control mechanism adopted, the difference between the highest and lowest temperature of any workpiece could be maintained within 5°C in the heat rising up period, which convincingly verifies the effectiveness of the proposed predictive control algorithm in different cases.
    Type of Medium: Online Resource
    ISSN: 0142-3312 , 1477-0369
    URL: Article
    DOI: 10.1177/0142331221989849
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2025882-3
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  • 9
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    Simulation Study of Passing Drivers’ Responses to the Autonomous Truck-Mounted Attenuator System in Road Maintenance
    SAGE Publications ; 2023
    In:  Transportation Research Record: Journal of the Transportation Research Board Vol. 2677, No. 6 ( 2023-06), p. 17-32
    Details
    In: Transportation Research Record: Journal of the Transportation Research Board, SAGE Publications, Vol. 2677, No. 6 ( 2023-06), p. 17-32
    Abstract: The autonomous truck-mounted attenuator (ATMA) system is a lead–follower vehicle system based on autonomous driving and connected vehicle technologies. The lead truck performs maintenance tasks on the road, and the unmanned follower truck alerts passing vehicles about the moving work zone and protects workers and the equipment. While the ATMA has been under testing by transportation maintenance and operations agencies recently, a simulator-based testing capability is a supplement, especially if human subjects are involved. This paper aims to discover how passing drivers perceive, understand, and react to the ATMA system in road maintenance. With the driving simulator developed for this ATMA study, the paper performed a simulation study wherein a screen-based eye tracker collected 16 subjects’ gaze points and pupil diameters. Data analysis evidenced the change in subjects’ visual attention patterns while passing the ATMA. On average, the ATMA starts to attract subjects’ attention from 500 ft behind the follower truck. Most (87.50%) understood the follower truck’s protection purpose, and many (60%) reasoned the association between the two trucks. Nevertheless, nearly half of the participants (43.75%) did not recognize that the ATMA is a connected autonomous vehicle system. While all subjects safely changed lanes and attempted to pass the slow-moving ATMA, their inadequate understanding of the ATMA is a potential risk, for issues such as cutting into the ATMA. The results implied that transportation maintenance and operations agencies should consider this in establishing the deployment guidance.
    Type of Medium: Online Resource
    ISSN: 0361-1981 , 2169-4052
    URL: Article
    DOI: 10.1177/03611981221144281
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2403378-9
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  • 10
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    Findings About Patient Preferences for Medical Care Based on a Decision Tree Method Study Design for Influencing Factors
    SAGE Publications ; 2022
    In:  INQUIRY: The Journal of Health Care Organization, Provision, and Financing Vol. 59 ( 2022-01), p. 004695802210928-
    Details
    In: INQUIRY: The Journal of Health Care Organization, Provision, and Financing, SAGE Publications, Vol. 59 ( 2022-01), p. 004695802210928-
    Abstract: Aim: This study aimed to investigate the influencing factors of the medical-seeking behavior of patients in a hospital in Nanning and descriptively analyze the main factors to further improve the medical system and optimize the allocation of health resources. Subject and methods: The willingness to seek medical treatment questionnaire survey was conducted on patients who were in the outpatient clinic of a hospital in Nanning from Jun 2018 to Aug 2019. The patients’ basic information was analyzed descriptively using the SPSS 23.0 software package, and the influencing factors of the willingness to seek medical treatment were analyzed by univariate analysis method. In addition, the importance of influencing factors in patient preference to seek medical treatment was explored by constructing a decision tree model. Results: A total of 3428 questionnaires were valid and the effective rate was 93.78%. Region, age, occupation, educational level, monthly income, insurance type, and disease type demonstrated diverse influences on the medical expenses of patients. In addition, differences were found between occupation and patient insurance situation, personal willingness to seek medical treatment, reasons for visiting the hospital, medical selection standard, preferred medical treatment location for common diseases, waiting time, treatment time, and manner of understanding the disease. Conclusion: Increasing attention has been paid on the patients’ preference for medical treatment and their satisfaction with medical services. Medical institutions should reasonably allocate the proportion of medical insurance reimbursement and diversify the registration and appointment methods. Patients should be treated in different periods and properly allocated to improve the service mechanism of primary medical institutions. In addition, it is necessary to improve the medical publicity model and the efficiency of medical services according to the needs of patients, so as to relieve the pressure of medical treatment in large general hospitals.
    Type of Medium: Online Resource
    ISSN: 0046-9580 , 1945-7243
    URL: Article
    DOI: 10.1177/00469580221092831
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2147137-X
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