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  • Li, Ying  (90)
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  • 1
    Online Resource
    Online Resource
    ChemInform Abstract: Selective Cleavage of Phenolic tert‐Butyldimethylsilyl Ethers Using Simple Organic Nitrogen Bases.
    Wiley ; 2010
    In:  ChemInform Vol. 41, No. 39 ( 2010-09-28)
    Details
    In: ChemInform, Wiley, Vol. 41, No. 39 ( 2010-09-28)
    Abstract: The process works best under the optimized conditions A).
    Type of Medium: Online Resource
    ISSN: 0931-7597 , 1522-2667
    URL: Issue
    URL: Article
    DOI: 10.1002/chin.v41:39
    DOI: 10.1002/chin.201039061
    Language: English
    Publisher: Wiley
    Publication Date: 2010
    detail.hit.zdb_id: 2110203-X
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  • 2
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    Valsartan reduced the vulnerability to atrial fibrillation by preventing action potential prolongation and conduction slowing in castrated male mice
    Wiley ; 2018
    In:  Journal of Cardiovascular Electrophysiology Vol. 29, No. 10 ( 2018-10), p. 1436-1443
    Details
    In: Journal of Cardiovascular Electrophysiology, Wiley, Vol. 29, No. 10 ( 2018-10), p. 1436-1443
    Abstract: Introduction: Deficiency of testosterone was associated with the susceptibility of atrial fibrillation (AF). Angiotensin‐II (AngII) receptor antagonists were shown to reduce AF by improving atrial electrical remodeling. This study investigated the effects and mechanism of valsartan, an AngII receptor antagonist, on the susceptibility to AF with testosterone deficiency. Methods and Results: Five‐week‐old male ICR mice were castrated and valsartan was administered orally (50 mg/kg/d). High‐frequency electrical stimulation method was used to induce atrial arrhythmia. Patch‐clamp technique was used for recording action potential duration (APD), transient outward potassium current ( I to ), sustained outward potassium current ( I ksus ), and late sodium current ( I Na‐L ). Optical mapping technique was used to examine atrial conduction velocity (CV). The expression of connexin40 (Cx40) and Cx43 were detected by Western blot analysis. The occurrence rate of AF was significantly increased in castrated mice and APDs measured at 50% and 90% repolarization were markedly prolonged in castrated mice than controls, which were alleviated by the administration of valsartan. Valsartan suppressed the increase of I Na‐L and rescued the reduction of I to and I ksus in castrated mice. The left atrial CV in castrated mice was decreased and the expression of Cx43 reduced than controls, which were restored after valsartan treatment. Conclusions: Valsartan reduced the susceptibility of AF in castrated mice, which may be related to the inhibition of action potential prolongation and improvement of atrial conduction impairment. This study indicates that valsartan may represent a useful agent for the prevention of AF pathogenesis in elderly male patients.
    Type of Medium: Online Resource
    ISSN: 1045-3873 , 1540-8167
    URL: Issue
    URL: Article
    DOI: 10.1111/jce.2018.29.issue-10
    DOI: 10.1111/jce.13697
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 2037519-0
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  • 3
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    Bradykinin‐mediated estrogen‐dependent depressor response by direct activation of female‐specific distribution of myelinated Ah‐type baroreceptor neurons in rats
    Wiley ; 2022
    In:  CNS Neuroscience & Therapeutics Vol. 28, No. 3 ( 2022-03), p. 435-447
    Details
    In: CNS Neuroscience & Therapeutics, Wiley, Vol. 28, No. 3 ( 2022-03), p. 435-447
    Abstract: To understand the direct impact of bradykinin in autonomic control of circulation through baroreflex afferent pathway. Methods The mean arterial pressure (MAP) was monitored while bradykinin and its agonists were applied via nodose (NG) microinjection, the expression of bradykinin receptors (BRs) in the NG (1 st ‐order) and nucleus tractus solitarius (NTS, 2 nd ‐order) were tested in adult male, age‐matched female, and ovariectomized rats under physiological and hypertensive conditions. Additionally, bradykinin‐induced depolarization was also tested in identified baroreceptor and baroreceptive neurons using whole‐cell patch‐clamp technique. Results Under physiological condition, bradykinin‐induced dose‐ and estrogen‐dependent reductions of MAP with lower estimated EC 50 in females. B 2 R agonist mediated more dramatic MAP reduction with long‐lasting effect compared with B 1 R activation. These functional observations were consistent with the molecular and immunostaining evidences. However, under hypertensive condition, the MAP reduction was significantly less dramatic in N ’ ‐Nitro‐L‐Arginine‐methyl ester (L‐NAME) induced secondary and spontaneous hypertension rats in males compared with female rats. Electrophysiological data showed that bradykinin‐elicited concentration‐dependent membrane depolarization with discharges during initial phase in identified myelinated Ah‐types baroreceptor neurons, not myelinated A‐types; while, higher concentration of bradykinin was required for depolarization of unmyelinated C‐types without initial discharges. Conclusion These datasets have demonstrated for the first time that bradykinin mediates direct activation of baroreflex afferent function to trigger estrogen‐dependent depressor response, which is due mainly to the direct activation/neuroexcitation of female‐specific myelinated Ah‐type baroreceptor neurons leading to a sexual dimorphism in parasympathetic domination of blood pressure regulation via activation of B 2 R/B 1 R expression in baroreflex afferent pathway.
    Type of Medium: Online Resource
    ISSN: 1755-5930 , 1755-5949
    URL: Article
    DOI: 10.1111/cns.13792
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2423467-9
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  • 4
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    Diagnostic Value of Serum YKL‐40 Level for Coronary Artery Disease: A Meta‐Analysis
    Wiley ; 2016
    In:  Journal of Clinical Laboratory Analysis Vol. 30, No. 1 ( 2016-01), p. 23-31
    Details
    In: Journal of Clinical Laboratory Analysis, Wiley, Vol. 30, No. 1 ( 2016-01), p. 23-31
    Abstract: This meta‐analysis aimed to identify the value of serum YKL‐40 level for the diagnosis of coronary artery disease (CAD). Methods Through searching the following electronic databases: the Cochrane Library Database (Issue 12, 2013), Web of Science (1945∼2013), PubMed (1966∼2013), CINAHL (1982∼2013), EMBASE (1980∼2013), and the Chinese Biomedical Database (CBM; 1982∼2013), related articles were determined without any language restrictions. STATA statistical software (Version 12.0, Stata Corporation, College Station, TX) was chosen to deal with statistical data. Standard mean difference (SMD) and its corresponding 95% confidence interval (95% CI) were calculated. Results Eleven clinical case‐control studies that recruited 1,175 CAD patients and 1,261 healthy controls were selected for statistical analysis. The main findings of our meta‐analysis showed that serum YKL‐40 level in CAD patients was significantly higher than that in control subjects (SMD = 2.79, 95% CI = 1.73∼3.85, P 〈 0.001). Ethnicity‐stratified analysis indicated a higher serum YKL‐40 level in CAD patients than control subjects among China, Korea, and Denmark populations (China: SMD = 2.97, 95% CI = 1.21∼4.74, P = 0.001; Korea: SMD = 0.66, 95% CI = 0.17∼1.15, P = 0.008; Denmark: SMD = 1.85, 95% CI = 1.42∼2.29, P 〈 0.001; respectively), but not in Turkey (SMD = 4.52, 95% CI = –2.87∼11.91, P = 0.231). Conclusion The present meta‐analysis suggests that an elevated serum YKL‐40 level may be used as a promising diagnostic tool for early identification of CAD.
    Type of Medium: Online Resource
    ISSN: 0887-8013 , 1098-2825
    URL: Issue
    URL: Article
    DOI: 10.1002/jcla.2016.30.issue-1
    DOI: 10.1002/jcla.21804
    Language: English
    Publisher: Wiley
    Publication Date: 2016
    detail.hit.zdb_id: 2001635-9
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  • 5
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    C otton Ann G h3 Encoding an Annexin Protein is Preferentially Expressed in Fibers and Promotes Initiation and Elongation of Leaf Trichomes in Transgenic Arabidopsis
    Wiley ; 2013
    In:  Journal of Integrative Plant Biology Vol. 55, No. 10 ( 2013-10), p. 902-916
    Details
    In: Journal of Integrative Plant Biology, Wiley, Vol. 55, No. 10 ( 2013-10), p. 902-916
    Abstract: The annexins are a multifamily of calcium‐regulated phospholipid‐binding proteins. To investigate the roles of annexins in fiber development, four genes encoding putative annexin proteins were isolated from cotton ( Gossypium hirsutum ) and designated AnnGh3 , AnnGh4 , AnnGh5 , and AnnGh6 . Quantitative reverse transcription‐polymerase chain reaction (qRT‐PCR) results indicated that AnnGh3 , AnnGh4 , and AnnGh5 were preferentially expressed in fibers, while the transcripts of AnnGh6 were predominantly accumulated in roots. During fiber development, the transcripts of AnnGh3/4/5 genes were mainly accumulated in rapidly elongating fibers. With fiber cells further developed, their expression activity was dramatically declined to a relatively low level. In situ hybridization results indicated that AnnGh3 and AnnGh5 were expressed in initiating fiber cells (0–2 DPA). Additionally, their expression in fibers was also regulated by phytohormones and [Ca 2+ ]. Subcellular localization analysis discovered that AnnGh3 protein was localized in the cytoplasm. Overexpression of AnnGh3 in Arabidopsis resulted in a significant increase in trichome density and length on leaves of the transgenic plants, suggesting that AnnGh3 may be involved in fiber cell initiation and elongation of cotton.
    Type of Medium: Online Resource
    ISSN: 1672-9072 , 1744-7909
    URL: Issue
    URL: Article
    DOI: 10.1111/jipb.v55.10
    DOI: 10.1111/jipb.12063
    Language: English
    Publisher: Wiley
    Publication Date: 2013
    detail.hit.zdb_id: 2130095-1
    SSG: 12
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  • 6
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    Some characteristics of clinical sequelae of COVID‐19 survivors from Wuhan, China: A multi‐center longitudinal study
    Wiley ; 2022
    In:  Influenza and Other Respiratory Viruses Vol. 16, No. 3 ( 2022-05), p. 395-401
    Details
    In: Influenza and Other Respiratory Viruses, Wiley, Vol. 16, No. 3 ( 2022-05), p. 395-401
    Abstract: The pandemic of COVID‐19 has a persistent impact on global health, yet its sequelae need to be addressed at a wide scale around the globe. This study aims to investigate the characteristics, prevalence, and risk factors for mid‐term ( 〉 6 months) clinical sequelae in a cohort of COVID‐19 survivors. Methods Totally 715 COVID‐19 survivors discharged before April 1, 2020, from three medical centers in Wuhan, China, were included. The longitudinal study was conducted by telephone interviews based on a questionnaire including the clinical sequelae of general, respiratory, and cardiovascular systems. Demographics and some characteristics of clinical sequelae of the survivors were recorded and analyzed. Multivariate logistic regression analysis was applied to explore the risk factors for the sequelae. Results The median time interval from discharge to telephone interview was 225.0 days. The COVID‐19 survivors' median ages were 69 years, and 51.3% were male. Among them, 29.9% had at least one clinical sequela. There were 19.2%, 22.7%, and 5.0% of the survivors reporting fatigue, respiratory symptoms, and cardiovascular symptoms, respectively. Comorbidities, disease severity, the application of mechanical ventilation and high‐flow oxygen therapy, and the history of re‐admission were associated with the presence of clinical sequelae. Conclusions Our study provides further evidence for the prevalence and characteristics of clinical sequelae of COVID‐19 survivors, suggesting long‐term monitoring and management is needed for their full recovery.
    Type of Medium: Online Resource
    ISSN: 1750-2640 , 1750-2659
    URL: Issue
    URL: Article
    DOI: 10.1111/irv.v16.3
    DOI: 10.1111/irv.12943
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2272349-3
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  • 7
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    Efficacy and brain mechanism of transcutaneous auricular vagus nerve stimulation for adolescents with mild to moderate depression: Study protocol for a randomized controlled trial
    Wiley ; 2020
    In:  Pediatric Investigation Vol. 4, No. 2 ( 2020-06), p. 109-117
    Details
    In: Pediatric Investigation, Wiley, Vol. 4, No. 2 ( 2020-06), p. 109-117
    Abstract: Depression is a common mental illness in childhood and adolescence, with an incidence of 4%–5%; it can lead to impairments in learning and social functioning. Transcutaneous auricular vagus nerve stimulation (taVNS) is a commonly used method of auricular acupuncture point stimulation, which is regarded as an effective treatment for adults with depression. The aim of this study was to investigate the efficacy and mechanism of taVNS for adolescents with mild to moderate depression. Methods This randomized controlled clinical trial will include 120 patients aged 12–16 years, all of whom are diagnosed with mild to moderate depression. Patients will be randomly assigned to a taVNS group and a drug control group (sertraline hydrochloride) at a ratio of 1:1. Patients will be evaluated using the 17‐item Hamilton Depression Scale, Hamilton Anxiety Rating Scale, Self‐Rating Depression Scale, Self‐Rating Anxiety Scale, and Pittsburgh Sleep Quality Index scores at baseline, as well as at the 2nd, 4th, 6th, 8th, and 12th weeks. To investigate the underlying neural mechanisms of taVNS treatment from the perspective of the default mode network, multimodal magnetic resonance imaging (MRI; i.e., structural MRI [sMRI], resting state MRI [rsMRI] , and pseudocontinuous arterial spin‐labeled [pcASL] MRI) will be used to compare cerebral images among groups. MRI data will also be collected from 40 healthy volunteers to assess whether the participants exhibit normal development of structural and functional components. Discussion Depression is the most common mental disorder in adolescence. Drug treatment can improve depression symptoms; however, the side effects of drug treatments are often severe. This study proposes a simple physiotherapy that aims to treat adolescents with mild to moderate depression. The mechanism of taVNS in the treatment of depression will also be investigated. The results of this study will provide evidence to guide the application of taVNS in adolescents with depression.
    Type of Medium: Online Resource
    ISSN: 2574-2272 , 2574-2272
    URL: Issue
    URL: Article
    DOI: 10.1002/ped4.v4.2
    DOI: 10.1002/ped4.12198
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2934365-3
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  • 8
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    ChemInform Abstract: New Fluoride-Promoted Hypoiodite-Catalytic Oxidative Cycloetherification to Aromatic Spiroketals.
    Wiley ; 2012
    In:  ChemInform Vol. 43, No. 39 ( 2012-09-25), p. no-no
    Details
    In: ChemInform, Wiley, Vol. 43, No. 39 ( 2012-09-25), p. no-no
    Type of Medium: Online Resource
    ISSN: 0931-7597
    URL: Article
    DOI: 10.1002/chin.201239106
    Language: English
    Publisher: Wiley
    Publication Date: 2012
    detail.hit.zdb_id: 2110203-X
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  • 9
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    Development and evaluation of a Novel RT‐PCR system for reliable and rapid SARS‐CoV ‐2 screening of blood donations
    Wiley ; 2020
    In:  Transfusion Vol. 60, No. 12 ( 2020-12), p. 2952-2961
    Details
    In: Transfusion, Wiley, Vol. 60, No. 12 ( 2020-12), p. 2952-2961
    Abstract: The ongoing outbreak of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) has caused great global concerns. In contrast to SARS, some SARS‐CoV‐2–infected people can be asymptomatic or have only mild nonspecific symptoms. Furthermore, there is evidence that SARS‐CoV‐2 may be infectious during an asymptomatic incubation period. With the discovery that SARS‐CoV‐2 can be detected in plasma or serum, blood safety is worthy of consideration. Study Design and Methods We developed a nucleic acid test (NAT) screening system for SARS‐CoV‐2 targeting nucleocapsid protein (N) and open reading frame 1ab (ORF 1ab) gene that could screen 5076 samples every 24 hours. The 2019 novel coronavirus RNA standard was used to evaluate linearity of standard curves. Diagnostic sensitivity and reproducibility were evaluated using artificial SARS‐CoV‐2. Specificity was evaluated with 61 other respiratory pathogens. Diagnostic performance was evaluated by testing two sputum and nine oropharyngeal swab specimens. The reverse transcription polymerase chain reaction (RT‐PCR) assay was used to screen SARS‐CoV‐2 RNA in blood donor specimens collected during the outbreak of SARS‐CoV‐2 in Chengdu. Results Limits of detection of the SARS‐CoV‐2 RT‐PCR assay for N and ORF 1ab gene were 12.5 and 27.58 copies/mL, respectively. Intra‐assay and interassay for the SARS‐CoV‐2 RT‐PCR assay based on cycle threshold were acceptably low. No cross‐reactivity was observed with other respiratory virus and bacterial isolates. The overall agreement value between the SARS‐CoV‐2 RT‐PCR assay and clinical diagnostic results was 100%. A total of 16 287 blood specimens collected from blood donors during SARS‐CoV‐2 surveillance were tested negative. Conclusions A high‐throughput NAT screening system was developed for SARS‐CoV‐2 screening of blood donations during the outbreak of SARS‐CoV‐2.
    Type of Medium: Online Resource
    ISSN: 0041-1132 , 1537-2995
    URL: Issue
    URL: Article
    DOI: 10.1111/trf.v60.12
    DOI: 10.1111/trf.16049
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2018415-3
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  • 10
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    Diagnosis of cognitive and motor disorders levels in stroke patients through explainable machine learning based on MRI
    Wiley ; 2023
    In:  Medical Physics
    Details
    In: Medical Physics, Wiley
    Abstract: Globally, stroke is the third most significant cause of disability. A stroke may produce motor, sensory, perceptual, or cognitive disorders that result in disability and affect the likelihood of recovery, affecting a person's ability to function. Evaluation post‐stroke is critical for optimal stroke care. Purpose Traditional methods for classifying the clinical disorders of cognitive and motor in stroke patients use assessment and interrogative measures, which are time‐consuming, complex, and labor‐intensive. In response to the current situation, this study develops an algorithm to automatically classify motor and cognitive disorders in stroke patients by 3D brain MRI to assist physicians in diagnosis. Methods First, radiomics and fusion features are extracted from the OAx T2 Propeller of 3D brain MRI. Then, we use 14 machine learning models and one model ensemble method to predict Fugl‐Meyer and MMSE levels of stroke patients. Next, we evaluate the models using accuracy, recall, f1‐score, and area under the curve (AUC). Finally, we employ SHAP to explain the output of the model. Results The best predictive models come from Random Forest (RF) Classifier with fusion features in cognitive classification and Linear Discriminant Analysis (LDA) with radiomics features in motor classification. The highest accuracies are 92.0 and 82.5% for cognitive and motor disorders. Conclusions MRI brain maps can classify the cognitive and motor disorders of stroke patients. Radiomics features demonstrate its merits. The proposed algorithms with MRI images can efficiently assist physicians in diagnosing the cognitive and motor disorders of stroke patients in clinical practice. Additionally, this lessens labor costs, improves diagnostic effectiveness, and avoids the subjective difference that comes with manual assessment.
    Type of Medium: Online Resource
    ISSN: 0094-2405 , 2473-4209
    URL: Article
    DOI: 10.1002/mp.16683
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 1466421-5
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