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  • Wiley  (10)
  • Li, Xiaolan  (10)
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  • Wiley  (10)
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  • 1
    Online Resource
    Online Resource
    An Insight into the Roles of Dietary Tryptophan and Its Metabolites in Intestinal Inflammation and Inflammatory Bowel Disease
    Wiley ; 2021
    In:  Molecular Nutrition & Food Research Vol. 65, No. 5 ( 2021-03)
    Details
    In: Molecular Nutrition & Food Research, Wiley, Vol. 65, No. 5 ( 2021-03)
    Abstract: Inflammatory bowel disease (IBD) is complex, chronic, and relapsing gastrointestinal inflammatory disorders, which includes mainly two conditions, namely ulcerative colitis (UC) and Crohn's disease (CD). Development of IBD in any individual is closely related to his/her autoimmune regulation, gene‐microbiota interactions, and dietary factors. Dietary tryptophan (Trp) is an essential amino acid for intestinal mucosal cells, and it is associated with the intestinal inflammation, epithelial barrier, and energy homeostasis of the host. According to recent studies, Trp and its three major metabolic pathways, namely kynurenine (KYN) pathway, indole pathway, and 5‐hydroxytryptamine (5‐HT) pathway, have vital roles in the regulation of intestinal inflammation by acting directly or indirectly on the pro/anti‐inflammatory cytokines, functions of various immune cells, as well as the intestinal microbial composition and homeostasis. In this review, recent advances in Trp‐ and its metabolites‐associated intestinal inflammation are summarized. It further discusses the complex mechanisms and interrelationships of the three major metabolic pathways of Trp in regulating inflammation, which could elucidate the value of dietary Trp to be used as a nutrient for IBD patients.
    Type of Medium: Online Resource
    ISSN: 1613-4125 , 1613-4133
    URL: Issue
    URL: Article
    DOI: 10.1002/mnfr.v65.5
    DOI: 10.1002/mnfr.202000461
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2160372-8
    SSG: 12
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  • 2
    Online Resource
    Online Resource
    p16 INK4A flow cytometry of exfoliated cervical cells: Its role in quantitative pathology and clinical diagnosis of squamous intraepithelial lesions
    Wiley ; 2023
    In:  Clinical and Translational Medicine Vol. 13, No. 3 ( 2023-03)
    Details
    In: Clinical and Translational Medicine, Wiley, Vol. 13, No. 3 ( 2023-03)
    Abstract: P16 INK4A is a surrogate signature compensating for the specificity and/or sensitivity deficiencies of the human papillomavirus (HPV) DNA and Papanicolaou smear (Pap) co‐test for detecting high‐grade cervical squamous intraepithelial lesions or worse (HSIL+). However, traditional p16INK4A immunostaining is labour intensive and skill demanding, and subjective biases cannot be avoided. Herein, we created a high‐throughput, quantitative diagnostic device, p16INK4A flow cytometry (FCM) and assessed its performances in cervical cancer screening and prevention. Methods P16 INK4A FCM was built upon a novel antibody clone and a series of positive and negative (p16 INK4A ‐knockout) standards. Since 2018, 24 100‐women (HPV‐positive/‐negative, Pap‐normal/‐abnormal) have been enrolled nationwide for two‐tier validation work. In cross‐sectional studies, age‐ and viral genotype‐dependent expression of p16 INK4A was investigated, and optimal diagnostic parameter cut‐offs (using colposcopy and biopsy as a gold standard) were obtained. In cohort studies, the 2‐year prognostic values of p16 INK4A were investigated with other risk factors by multivariate regression analyses in three cervicopathological conditions: HPV‐positive Pap‐normal, Pap‐abnormal biopsy‐negative and biopsy‐confirmed LSIL. Results P16 INK4A FCM detected a minimal ratio of 0.01% positive cells. The p16 INK4A ‐positive ratio was 13.9 ± 1.8% among HPV‐negative NILM women and peaked at the ages of 40–49 years; after HPV infection, the ratio increased to 15.1 ± 1.6%, varying with the carcinogenesis of the viral genotype. Further increments were found in women with neoplastic lesions (HPV‐negative: 17.7 ± 5.0–21.4 ± 7.2%; HPV‐positive: 18.0 ± 5.2–20.0 ± 9.9%). Extremely low expression of p16 INK4A was observed in women with HSILs. As the HPV‐combined double‐cut‐off‐ratio criterion was adopted, a Youden's index of 0.78 was obtained, which was significantly higher than that (0.72) of the HPV and Pap co‐test. The p16 INK4A ‐abnormal situation was an independent HSIL+ risk factor for 2‐year outcomes in all three cervicopathological conditions investigated (hazard ratios: 4.3–7.2). Conclusions FCM‐based p16 INK4A quantification offers a better choice for conveniently and precisely monitoring the occurrence of HSIL+ and directing risk‐stratification‐based interventions.
    Type of Medium: Online Resource
    ISSN: 2001-1326 , 2001-1326
    URL: Issue
    URL: Article
    DOI: 10.1002/ctm2.v13.3
    DOI: 10.1002/ctm2.1209
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2697013-2
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  • 3
    Online Resource
    Online Resource
    Construction of Pyridine Ring Systems by Mn(OAc) 2 ‐Promoted Formal Dehydrative Dehydroaromatizing [4+2] Cycloaddition of Enamides with Maleimides
    Wiley ; 2022
    In:  Advanced Synthesis & Catalysis Vol. 364, No. 10 ( 2022-05-17), p. 1683-1688
    Details
    In: Advanced Synthesis & Catalysis, Wiley, Vol. 364, No. 10 ( 2022-05-17), p. 1683-1688
    Abstract: Herein, we report a Mn(OAc) 2 ‐promoted formal dehydrative dehydroaromatizing [4+2] cycloaddition of enamides with maleimides for the construction of pyridine rings to access the diverse synthetically valuable pyrrolo[3,4‐c] ‐pyridine derivatives. This protocol allows two C−C bond formation for the assembly of pyridine derivatives from enamides synthesizable in two steps and inexpensive maleimides, which exhibits broad substrate scope and good functional group compatibility. magnified image
    Type of Medium: Online Resource
    ISSN: 1615-4150 , 1615-4169
    URL: Issue
    URL: Article
    DOI: 10.1002/adsc.v364.10
    DOI: 10.1002/adsc.202200251
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2041384-1
    detail.hit.zdb_id: 2033084-4
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  • 4
    Online Resource
    Online Resource
    Copper‐Mediated Phosphorylation of Arylsilanes with H‐Phosphonate Diesters
    Wiley ; 2020
    In:  Asian Journal of Organic Chemistry Vol. 9, No. 12 ( 2020-12), p. 2083-2086
    Details
    In: Asian Journal of Organic Chemistry, Wiley, Vol. 9, No. 12 ( 2020-12), p. 2083-2086
    Abstract: Herein we report a facile method for the synthesis of arylphosphonates via copper‐mediated the cross‐coupling reaction in the presence of 1, 10‐Phenanthroline and Ag 2 O. This method features a broad scope with respect to both the arylsilanes and H‐phosphonate diesters. Mechanistically, the reaction is proposed to involve oxidation by phosphinyl radical and reductive elimination process as the two key steps. With the optimized conditions established, various arylphosphonates were obtained up to 74% yield. This protocol is the first example of copper mediated the Ar−P bond formation of various arylsilanes with H‐phosphonates, and this novel methodology expands the applications of low cost and toxicity copper reagent in Ar−P bond construction.
    Type of Medium: Online Resource
    ISSN: 2193-5807 , 2193-5815
    URL: Issue
    URL: Article
    DOI: 10.1002/ajoc.v9.12
    DOI: 10.1002/ajoc.202000529
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2679333-7
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  • 5
    Online Resource
    Online Resource
    Large‐scale Synthesis of Porous Pt Nanospheres /Three‐dimensional Graphene Hybrid Materials as a Highly Active and Stable Electrocatalyst for Oxygen Reduction Reaction
    Wiley ; 2021
    In:  ChemistrySelect Vol. 6, No. 9 ( 2021-03-05), p. 2080-2084
    Details
    In: ChemistrySelect, Wiley, Vol. 6, No. 9 ( 2021-03-05), p. 2080-2084
    Abstract: In order to facilitate widespread commercialization of proton‐exchange membrane fuel cells (PEMFCs), the synthesis of advanced catalysts toward oxygen reduction reaction with high activity and stability is essential. Here, we report the synthesis of strongly coupled porous Pt nanospheres /three‐dimensional graphene (P−Pt @3DG) hybrid materials through a facile strategy. The P−Pt @3DG displays an excellent oxygen reduction reaction (ORR) performance with the mass activity of 0.542 A/mg Pt and specific activity of 0.976 mA/cm 2 at 0.9 V vs. RHE, respectively, which are 4.0‐ and 3.7‐ times higher than those of commercial Pt/C catalysts. More importantly, high stability with only 5.35 % loss after 10,000 cycles is achieved. The superior performance of P−Pt @3DG is mainly attributed to the open structure of porous Pt spheres, which exposes the internal Pt atoms with an ultrahigh Pt utilization. Moreover, the 3D graphenes possess an open and interconnected porous structure and allow efficient charge and mass transfer. Besides, this synthetic method is suitable for large scale production, which is highly applicable to the commercialization of PEMFCs.
    Type of Medium: Online Resource
    ISSN: 2365-6549 , 2365-6549
    URL: Issue
    URL: Article
    DOI: 10.1002/slct.v6.9
    DOI: 10.1002/slct.202004718
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2844262-3
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  • 6
    Online Resource
    Online Resource
    Enhancing rheological properties of hydrophobically associative polyacrylamide aqueous solutions by hybriding with silica nanoparticles
    Wiley ; 2014
    In:  Journal of Applied Polymer Science Vol. 131, No. 19 ( 2014-10-05)
    Details
    In: Journal of Applied Polymer Science, Wiley, Vol. 131, No. 19 ( 2014-10-05)
    Abstract: Organic/inorganic hybrid aqueous solutions were prepared by mixing silica nanoparticle suspension and hydrophobically associating polyacrylamide (HAPAM) solution, and their rheological behaviors were examined in both pure water and brine in comparison with HAPAM. It was found that HAPAM/silica hybrid exhibits viscosity enhancement in aqueous solution and better heat‐ and salt‐ tolerances than HAPAM. Meanwhile, their long‐term thermal stability is also improved. Cryo‐TEM observation reveals that a reinforced three‐dimensional network structure of HAPAM/silica hybrid is formed. These improved properties are attributed to the formed hydrogen bond between carbonyl groups in HAPAM skeleton and silanol functionalities in silica nanoparticles in the hybrid system, and the silica nanoparticles in the hybrid act as physical crosslinkers between macromolecules. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014 , 131 , 40876.
    Type of Medium: Online Resource
    ISSN: 0021-8995 , 1097-4628
    URL: Issue
    URL: Article
    DOI: 10.1002/app.v131.19
    DOI: 10.1002/app.40876
    Language: English
    Publisher: Wiley
    Publication Date: 2014
    detail.hit.zdb_id: 1491105-X
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  • 7
    Online Resource
    Online Resource
    Short‐term weight loss decreased the risk of chronic kidney disease in men with incident nonalcoholic fatty liver disease
    Wiley ; 2022
    In:  Obesity Vol. 30, No. 7 ( 2022-07), p. 1495-1506
    Details
    In: Obesity, Wiley, Vol. 30, No. 7 ( 2022-07), p. 1495-1506
    Abstract: The study aimed to examine the association of obesity and chronic kidney disease (CKD) after nonalcoholic fatty liver disease (NAFLD) occurrence. Methods The study enrolled 10,311 adult men with newly diagnosed NAFLD and without CKD in the Kailuan cohort (2006–2013). The Fine‐Gray model was used to compare advanced CKD risk in NAFLD with different baseline or trajectories in obesity measures. Results During a median follow‐up of 10 years, maintaining normal waist circumference or waist‐hip ratio, or transition from obesity to nonobesity determined by BMI, decreased 31% (hazard ratio [HR] = 0.69; 95% CI: 0.51–0.93), 34% (HR = 0.66; 95% CI: 0.45–0.95), and 38% (HR = 0.62; 95% CI: 0.40–0.96) of the CKD hazard compared with the “constantly without obesity” subgroup, respectively. NAFLD patients with at least 10% weight loss (HR = 0.58; 95% CI: 0.34–0.97) and with 7.0% to 9.9% weight loss (HR = 0.53; 95% CI: 0.28–0.99) had a lower risk for CKD than those with weight change ±4.9%. Compared with the stable weight population, the lower risk of ≥7% weight loss was observed only in patients with elevated blood pressure (adjusted HR = 0.48; 95% CI: 0.28–0.81). Conclusions Short‐term weight loss of at least 7% could decrease CKD risk, especially among patients with obesity and elevated blood pressure. It is important to monitor waist circumference, waist‐hip ratio, and weight for NAFLD management.
    Type of Medium: Online Resource
    ISSN: 1930-7381 , 1930-739X
    URL: Issue
    URL: Article
    DOI: 10.1002/oby.v30.7
    DOI: 10.1002/oby.23459
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2027211-X
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  • 8
    Online Resource
    Online Resource
    Application of nonthermal processing technologies in extracting and modifying polysaccharides: A critical review
    Wiley ; 2021
    In:  Comprehensive Reviews in Food Science and Food Safety Vol. 20, No. 5 ( 2021-09), p. 4367-4389
    Details
    In: Comprehensive Reviews in Food Science and Food Safety, Wiley, Vol. 20, No. 5 ( 2021-09), p. 4367-4389
    Abstract: Polysaccharides are natural polymer compounds widely distributed in plants, animals, and microorganisms, most of which have a broad spectrum of biological activities to promote human health. They could also be used as texture modifiers in food industry due to their excellent rheological and mechanical properties. Many researchers have shown that nonthermal processing technologies have numerous advantages, such as high extraction efficiency, short extraction time, and environmental friendliness, in the extraction of polysaccharides compared with the traditional extraction methods. Moreover, nonthermal technologies could effectively change the physicochemical properties and structural characteristics of polysaccharides to improve their biological activities or processing properties. Therefore, a comprehensive summary about the extraction and modification of polysaccharides by nonthermal technologies, including ultrasound, high hydrostatic pressure, pulsed electric fields, and cold plasma, was provided in this review. In particular, the underlying mechanisms, processing operations, and current application status of these technologies were discussed. In addition, the applications of combining nonthermal techniques with other technological methods in polysaccharide extraction and modification were briefly introduced.
    Type of Medium: Online Resource
    ISSN: 1541-4337 , 1541-4337
    URL: Issue
    URL: Article
    DOI: 10.1111/crf3.v20.5
    DOI: 10.1111/1541-4337.12820
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2185829-9
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  • 9
    Online Resource
    Online Resource
    Dislocations related with the pore on P‐rich InP wafer
    Wiley ; 2013
    In:  physica status solidi c Vol. 10, No. 11 ( 2013-11), p. 1373-1376
    Details
    In: physica status solidi c, Wiley, Vol. 10, No. 11 ( 2013-11), p. 1373-1376
    Abstract: The two dimension distributions of dislocation and thermal stress of 3‐inch diameter stoichiometric and P‐rich InP wafers are investigated, and an analysis of the relation between the two distributions is given. As a result, in stoichiometric and P‐rich InP wafers, both the dislocation and thermal stress distributions are found to be circular ring shape, and where the thermal stress is stronger, the etch‐pits density (EPD) is higher, too. On the P‐rich wafers, there are some pores where EPD is much higher than other areas, around most pores, thermal stress is very strong, but around a small number of pores, the thermal stress is weaker as a contrary, that may be because the residual thermal stress can be released along the pores penetrating through the ingot during ingot annealing. Thermal stress is one of the main reasons which can contribute to dislocation. (© 2013 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
    Type of Medium: Online Resource
    ISSN: 1862-6351 , 1610-1642
    URL: Issue
    URL: Article
    DOI: 10.1002/pssc.v10.11
    DOI: 10.1002/pssc.201300277
    Language: English
    Publisher: Wiley
    Publication Date: 2013
    detail.hit.zdb_id: 2105580-4
    detail.hit.zdb_id: 2102966-0
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  • 10
    Online Resource
    Online Resource
    Catalyst‐Free, Air‐Mediated C( sp 2 )−H Alkylation of Cyclic Aldimines with Alkylboronic Acids
    Wiley ; 2023
    In:  Advanced Synthesis & Catalysis Vol. 365, No. 24 ( 2023-12-19), p. 4544-4549
    Details
    In: Advanced Synthesis & Catalysis, Wiley, Vol. 365, No. 24 ( 2023-12-19), p. 4544-4549
    Abstract: The air mediated radical alkylation of cyclic aldimines via autoxidation of alkylboronic acids has been realized under mild reaction conditions. By simply heating cyclic aldimines with alkylboronic acid using air as sole oxidant, this protocol provides a catalyst‐free access to a variety of alkylated cyclic aldimines with 21–91% yields. Preliminary mechanistic studies suggest that a radical pathway might be involved in the reaction.
    Type of Medium: Online Resource
    ISSN: 1615-4150 , 1615-4169
    URL: Issue
    URL: Article
    DOI: 10.1002/adsc.v365.24
    DOI: 10.1002/adsc.202301093
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2041384-1
    detail.hit.zdb_id: 2033084-4
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