In:
Angewandte Chemie, Wiley, Vol. 130, No. 39 ( 2018-09-24), p. 13012-13016
Abstract:
The first sensitive fluorescence . OH probe ( 1 ) that is capable of monitoring the generation of trace . OH in iron autoxidation is presented. The probe 1 was designed by utilizing both the unique aromatic hydroxylation and the electrophilicity of . OH, and prepared by incorporating a strong electron‐donating methoxy group into a cyanine fluorochrome to enhance the trapping ability for . OH. Reaction of 1 with . OH leads to a larger π‐conjugation formation and near‐infrared fluorescence off–on response. The capability of probe 1 has been demonstrated by imaging . OH generated in living cells under iron autoxidation as well as various stimuli, which reveals that the basal level of . OH in RAW 264.7 cells is lower than that in HeLa cells. The superior analytical performance of probe 1 makes it useful for detecting trace . OH in some critical physiological and pathological processes associated with iron autoxidation.
Type of Medium:
Online Resource
ISSN:
0044-8249
,
1521-3757
DOI:
10.1002/ange.v130.39
DOI:
10.1002/ange.201808400
Language:
English
Publisher:
Wiley
Publication Date:
2018
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