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  • 1
    Online Resource
    Online Resource
    Targeting Ferroptosis by Polydopamine Nanoparticles Protects Heart against Ischemia/Reperfusion Injury
    American Chemical Society (ACS) ; 2021
    In:  ACS Applied Materials & Interfaces Vol. 13, No. 45 ( 2021-11-17), p. 53671-53682
    Details
    In: ACS Applied Materials & Interfaces, American Chemical Society (ACS), Vol. 13, No. 45 ( 2021-11-17), p. 53671-53682
    Type of Medium: Online Resource
    ISSN: 1944-8244 , 1944-8252
    URL: Article
    URL: Article
    DOI: 10.1021/acsami.1c18061
    DOI: 10.1021/acsami.1c18061.s001
    Language: English
    Publisher: American Chemical Society (ACS)
    Publication Date: 2021
    detail.hit.zdb_id: 2467494-1
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  • 2
    Online Resource
    Online Resource
    Myocardial‐Targeting Tannic Cerium Nanocatalyst Attenuates Ischemia/Reperfusion Injury
    Wiley ; 2023
    In:  Angewandte Chemie Vol. 135, No. 39 ( 2023-09-25)
    Details
    In: Angewandte Chemie, Wiley, Vol. 135, No. 39 ( 2023-09-25)
    Abstract: Ischemic heart disease (IHD) is one of the leading causes of death worldwide. Medications or surgery have been considered as effective protocols to treat IHD for decades. Yet the reperfusion of the blood flow frequently leads to the generation of excessive reactive oxygen species (ROS), causing prominent and irreversible damage to the cardiomyocytes. In the present work, tannic acid‐assembled tetravalent cerium (TA−Ce) nanocatalysts with appealing cardiomyocyte‐targeting and antioxidation capability have been synthesized and applied for the effective and biocompatible ischemia/reperfusion injury therapeutics. TA−Ce nanocatalysts could effectively rescue the cardiomyocytes from oxidative stress induced by H 2 O 2 challenge as well as oxygen‐glucose deprivation in vitro. In the murine ischemia/reperfusion model, cardiac accumulation and intracellular ROS scavenging could be achieved against the pathology, substantially reducing the myocardial infarct area and recovering heart functionality. This work illuminates the design of nanocatalytic metal complexes and their therapeutic prospects in ischemic heart diseases with high effectiveness and biocompatibility, paving the way for the clinical translation from bench to bedside.
    Type of Medium: Online Resource
    ISSN: 0044-8249 , 1521-3757
    URL: Issue
    URL: Article
    DOI: 10.1002/ange.v135.39
    DOI: 10.1002/ange.202305576
    RVK:
    VA 2100
    RVK:
    VN 5020
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 505868-5
    detail.hit.zdb_id: 506609-8
    detail.hit.zdb_id: 514305-6
    detail.hit.zdb_id: 505872-7
    detail.hit.zdb_id: 1479266-7
    detail.hit.zdb_id: 505867-3
    detail.hit.zdb_id: 506259-7
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  • 3
    Online Resource
    Online Resource
    Myocardial‐Targeting Tannic Cerium Nanocatalyst Attenuates Ischemia/Reperfusion Injury
    Wiley ; 2023
    In:  Angewandte Chemie International Edition Vol. 62, No. 39 ( 2023-09-25)
    Details
    In: Angewandte Chemie International Edition, Wiley, Vol. 62, No. 39 ( 2023-09-25)
    Abstract: Ischemic heart disease (IHD) is one of the leading causes of death worldwide. Medications or surgery have been considered as effective protocols to treat IHD for decades. Yet the reperfusion of the blood flow frequently leads to the generation of excessive reactive oxygen species (ROS), causing prominent and irreversible damage to the cardiomyocytes. In the present work, tannic acid‐assembled tetravalent cerium (TA−Ce) nanocatalysts with appealing cardiomyocyte‐targeting and antioxidation capability have been synthesized and applied for the effective and biocompatible ischemia/reperfusion injury therapeutics. TA−Ce nanocatalysts could effectively rescue the cardiomyocytes from oxidative stress induced by H 2 O 2 challenge as well as oxygen‐glucose deprivation in vitro. In the murine ischemia/reperfusion model, cardiac accumulation and intracellular ROS scavenging could be achieved against the pathology, substantially reducing the myocardial infarct area and recovering heart functionality. This work illuminates the design of nanocatalytic metal complexes and their therapeutic prospects in ischemic heart diseases with high effectiveness and biocompatibility, paving the way for the clinical translation from bench to bedside.
    Type of Medium: Online Resource
    ISSN: 1433-7851 , 1521-3773
    URL: Issue
    URL: Article
    DOI: 10.1002/anie.v62.39
    DOI: 10.1002/anie.202305576
    RVK:
    VA 2100
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2011836-3
    detail.hit.zdb_id: 123227-7
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  • 4
    Online Resource
    Online Resource
    Ischemic Microenvironment‐Responsive Therapeutics for Cardiovascular Diseases
    Wiley ; 2021
    In:  Advanced Materials Vol. 33, No. 52 ( 2021-12)
    Details
    In: Advanced Materials, Wiley, Vol. 33, No. 52 ( 2021-12)
    Abstract: Cardiovascular diseases caused by ischemia are attracting considerable attention owing to its high morbidity and mortality worldwide. Although numerous agents with cardioprotective benefits have been identified, their clinical outcomes are hampered by their low bioavailability, poor drug solubility, and systemic adverse effects. Advances in nanoscience and nanotechnology provide a new opportunity to effectively deliver drugs for treating ischemia‐related diseases. In particular, cardiac ischemia leads to a characteristic pathological environment called an ischemic microenvironment (IME), significantly different from typical cardiac regions. These remarkable differences between ischemic sites and normal tissues have inspired the development of stimuli‐responsive systems for the targeted delivery of therapeutic drugs to damaged cardiomyocytes. Recently, many biomaterials with intelligent properties have been developed to enhance the therapeutic benefits of drugs for the treatment of myocardial ischemia. Strategies for stimuli‐responsive drug delivery and release based on IME include reactive oxygen species, pH‐, hypoxia‐, matrix metalloproteinase‐, and platelet‐inspired targeting strategies. In this review, state‐of‐the‐art IME‐responsive biomaterials for the treatment of myocardial ischemia are summarized. Perspectives, limitations, and challenges are also discussed for the further development of innovative and effective approaches to treat ischemic diseases with high effectiveness and biocompatibility.
    Type of Medium: Online Resource
    ISSN: 0935-9648 , 1521-4095
    URL: Issue
    URL: Article
    DOI: 10.1002/adma.v33.52
    DOI: 10.1002/adma.202105348
    RVK:
    UA 1538
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 1474949-X
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  • 5
    Online Resource
    Online Resource
    Fabry disease: Mechanism and therapeutics strategies
    Frontiers Media SA ; 2022
    In:  Frontiers in Pharmacology Vol. 13 ( 2022-10-26)
    Details
    In: Frontiers in Pharmacology, Frontiers Media SA, Vol. 13 ( 2022-10-26)
    Abstract: Fabry disease is a monogenic disease characterized by a deficiency or loss of the α-galactosidase A (GLA). The resulting impairment in lysosomal GLA enzymatic activity leads to the pathogenic accumulation of enzymatic substrate and, consequently, the progressive appearance of clinical symptoms in target organs, including the heart, kidney, and brain. However, the mechanisms involved in Fabry disease-mediated organ damage are largely ambiguous and poorly understood, which hinders the development of therapeutic strategies for the treatment of this disorder. Although currently available clinical approaches have shown some efficiency in the treatment of Fabry disease, they all exhibit limitations that need to be overcome. In this review, we first introduce current mechanistic knowledge of Fabry disease and discuss potential therapeutic strategies for its treatment. We then systemically summarize and discuss advances in research on therapeutic approaches, including enzyme replacement therapy (ERT), gene therapy, and chaperone therapy, as well as strategies targeting subcellular compartments, such as lysosomes, the endoplasmic reticulum, and the nucleus. Finally, the future development of potential therapeutic strategies is discussed based on the results of mechanistic studies and the limitations associated with these therapeutic approaches.
    Type of Medium: Online Resource
    ISSN: 1663-9812
    URL: Article
    DOI: 10.3389/fphar.2022.1025740
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2587355-6
    SSG: 15,3
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  • 6
    Online Resource
    Online Resource
    Nanozymes-recent development and biomedical applications
    Springer Science and Business Media LLC ; 2022
    In:  Journal of Nanobiotechnology Vol. 20, No. 1 ( 2022-02-22)
    Details
    In: Journal of Nanobiotechnology, Springer Science and Business Media LLC, Vol. 20, No. 1 ( 2022-02-22)
    Abstract: Nanozyme is a series of nanomaterials with enzyme-mimetic activities that can proceed with the catalytic reactions of natural enzymes. In the field of biomedicine, nanozymes are capturing tremendous attention due to their high stability and low cost. Enzyme-mimetic activities of nanozymes can be regulated by multiple factors, such as the chemical state of metal ion, pH, hydrogen peroxide (H 2 O 2 ), and glutathione (GSH) level, presenting great promise for biomedical applications. Over the past decade, multi-functional nanozymes have been developed for various biomedical applications. To promote the understandings of nanozymes and the development of novel and multifunctional nanozymes, we herein provide a comprehensive review of the nanozymes and their applications in the biomedical field. Nanozymes with versatile enzyme-like properties are briefly overviewed, and their mechanism and application are discussed to provide understandings for future research. Finally, underlying challenges and prospects of nanozymes in the biomedical frontier are discussed in this review. Graphical Abstract
    Type of Medium: Online Resource
    ISSN: 1477-3155
    URL: Article
    DOI: 10.1186/s12951-022-01295-y
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2022
    detail.hit.zdb_id: 2100022-0
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  • 7
    Online Resource
    Online Resource
    Biominerallized Noble Metal‐Based RuO 2 Nanozymes Against Myocardial Ischemic/Reperfusion Injury
    Wiley ; 2023
    In:  Advanced NanoBiomed Research Vol. 3, No. 5 ( 2023-05)
    Details
    In: Advanced NanoBiomed Research, Wiley, Vol. 3, No. 5 ( 2023-05)
    Abstract: Myocardial ischemia/reperfusion (IR) injury is the leading cause of morbidity and mortality among elderly worldwide. Oxidative burst, which involves the rapid release of reactive oxygen species (ROS), is the primary mechanism of IR‐mediated myocardial dysfunction and injury. Therefore, ROS elimination shows great potential for modulating IR injury. Herein, BSA‐coated RuO 2 nanoparticles (RuO 2 @BSA, RA NPs) as free radical scavengers are synthesized and their therapeutic effect against myocardial IR injury is explored. The in vitro antioxidant effect of RA NPs in cardiomyocytes is initially demonstrated. In ischemic myocardium, the RA NPs mimic multiple enzymes to remarkably reduce the infarcted area and restore cardiac function through a cascade of enzyme‐like reactions, including the transformation of superoxide anion into hydrogen peroxide (H 2 O 2 ) and the subsequent decomposition of H 2 O 2 to oxygen. The therapeutic mechanism of the RA NPs is based on ROS scavenging and the inhibition of apoptosis. These findings demonstrate the high clinical potential of RA NPs in IR injury treatment.
    Type of Medium: Online Resource
    ISSN: 2699-9307 , 2699-9307
    URL: Issue
    URL: Article
    DOI: 10.1002/anbr.v3.5
    DOI: 10.1002/anbr.202200144
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 3009938-9
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