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  • SAGE Publications  (6)
  • Li, Wei  (6)
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  • SAGE Publications  (6)
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  • 1
    In: Journal of Endovascular Therapy, SAGE Publications, Vol. 22, No. 6 ( 2015-12), p. 942-949
    Abstract: Purpose: To evaluate the rate of stent malapposition, plaque prolapse, and fibrous cap rupture detected by optical coherence tomography (OCT) after carotid artery stenting (CAS) based on the presence of lipid-rich plaque, which may be associated with acute stent thrombosis. Methods: A retrospective study was conducted involving 26 consecutive patients who underwent CAS with OCT imaging acquired before stent deployment and after stent dilation. Adequate imaging quality could not be obtained in 6 patients (out-of-screen images and residual blood), which left 20 patients (mean age 63 years; 13 men) for analysis. Plaque characteristics were determined from 500 selected OCT cross sections; a lipid-rich plaque was defined by lipid present in ≥2 quadrants. Cross-sectional OCT images within the stented segment were evaluated at 1-mm intervals for the presence of malapposition, plaque prolapse, and fibrous cap rupture. The data were compared between patients with and without lipid-rich plaques. The patients were examined at 6 months to determine the degree of in-stent restenosis (ISR). Results: Patients with lipid-rich plaque demonstrated a higher rate of embedded stent struts (29.4% vs 23.7%, p 〈 0.001) and a lower rate of well apposed struts (54.6% vs 59.6%, p 〈 0.001) compared to patients with non–lipid-rich plaque. Rates of plaque prolapse (65.5% vs 49.1%, p 〈 0.001) and fibrous cap rupture (65.5% vs 49.1%, p 〈 0.001) were significantly higher in patients with lipid-rich plaque. ISR ranged from none to 42% in 12 patients; malapposed stent struts and fibrous cap ruptures were not more frequent in the patients with obvious ISR. The 8 patients with no obvious restenosis still had malapposed struts, embedded struts, plaque prolapse, and fibrous cap rupture. Conclusion: Embedded stent struts, plaque prolapse, and fibrous cap rupture were more frequent and well-apposed stent struts were less frequent after CAS in patients with lipid-rich plaque.
    Type of Medium: Online Resource
    ISSN: 1526-6028 , 1545-1550
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2015
    detail.hit.zdb_id: 2049858-5
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  • 2
    Online Resource
    Online Resource
    SAGE Publications ; 2018
    In:  Advances in Mechanical Engineering Vol. 10, No. 9 ( 2018-09), p. 168781401879778-
    In: Advances in Mechanical Engineering, SAGE Publications, Vol. 10, No. 9 ( 2018-09), p. 168781401879778-
    Abstract: Bearings are crucial for industrial production and susceptible to malfunction in rotating machines. Image analysis can give a comprehensive description of vibration signal, thus, it has achieved much more attention recently in fault diagnosis field. However, it brings lots of redundant information from a single spectrum image matrix behind rich fault information, and massive spectrum image samples lead to exacerbation of this situation, which readily results in the accuracy-dropping problem of multiple local defective bearings diagnosis. To solve this issue, a novel feature extraction method based on image sparse representation is proposed. Original spectrum images are acquired through fast Fourier transformation. Sparse coefficient that reveals the underlying structure of spectrum image based on raw signals is extracted as the feature by implementing the orthogonal matching pursuit and K-singular value decomposition algorithm strategically, and then two-dimensional principal component analysis is applied for further processing of these features. Finally, fault types are identified based on a minimum distance strategy. The experimental results are given to demonstrate the effectiveness of the proposed method.
    Type of Medium: Online Resource
    ISSN: 1687-8140 , 1687-8140
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
    detail.hit.zdb_id: 2501620-9
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  • 3
    Online Resource
    Online Resource
    SAGE Publications ; 2017
    In:  Advances in Mechanical Engineering Vol. 9, No. 9 ( 2017-09), p. 168781401772725-
    In: Advances in Mechanical Engineering, SAGE Publications, Vol. 9, No. 9 ( 2017-09), p. 168781401772725-
    Type of Medium: Online Resource
    ISSN: 1687-8140 , 1687-8140
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2017
    detail.hit.zdb_id: 2501620-9
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  • 4
    Online Resource
    Online Resource
    SAGE Publications ; 2018
    In:  Advances in Mechanical Engineering Vol. 10, No. 3 ( 2018-03), p. 168781401876482-
    In: Advances in Mechanical Engineering, SAGE Publications, Vol. 10, No. 3 ( 2018-03), p. 168781401876482-
    Type of Medium: Online Resource
    ISSN: 1687-8140 , 1687-8140
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
    detail.hit.zdb_id: 2501620-9
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  • 5
    In: Therapeutic Advances in Medical Oncology, SAGE Publications, Vol. 12 ( 2020-01), p. 175883592096584-
    Abstract: Carboxyamidotriazole (CAI), a calcium channel blocker, inhibits tumor cell proliferation, metastasis, and angiogenesis. This trial aimed to determine whether CAI combined with conventional chemotherapy could prolong progression-free survival (PFS) in non-small cell lung cancer (NSCLC) patients. Methods: Patients were assigned into groups (3:1 ratio) to receive either chemotherapy + CAI or chemotherapy alone. Cisplatin (25 mg/m 2 ) was administered by intravenous infusion on days 1, 2, and 3, and vinorelbine (25 mg/m 2 ) on days 1 and 8 of each 3-week cycle for four cycles. CAI was administered at 100 mg daily with concomitant chemotherapy; this treatment was continued after chemotherapy was ceased until serious toxicity or disease progression had occurred. PFS was the primary endpoint, and the secondary endpoints were objective response rate (ORR), disease control rate, overall survival (OS), and quality of life. Results: In total, 495 patients were enrolled in the trial: 378 in the chemotherapy + CAI group and 117 in the chemotherapy + placebo group. PFS was significantly greater in the chemotherapy + CAI [median, 134 days; 95% confidence interval (CI) 127–139] than in the chemotherapy + placebo (median, 98 days; 95% CI: 88–125) group, with a hazard ratio of 0.690 (95% CI: 0.539–0.883; p = 0.003). There was no difference in the OS rates of both groups. The ORR was greater in the chemotherapy + CAI group than in the chemotherapy + placebo group (34.6% versus 25.0%, p = 0.042). Adverse events of ⩾grade 3 occurred more frequently in the CAI group [256 (68.1%) versus 64 (55.2%); p = 0.014] . Conclusion: CAI + platinum-based chemotherapy prolonged PFS and could be a useful therapeutic option to treat NSCLC. Clinical Trial Registration: chinadrugtrials.org.cn identifier: CTR20160395
    Type of Medium: Online Resource
    ISSN: 1758-8359 , 1758-8359
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2503443-1
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  • 6
    Online Resource
    Online Resource
    SAGE Publications ; 2012
    In:  Advances in Mechanical Engineering Vol. 4 ( 2012-01), p. 518468-
    In: Advances in Mechanical Engineering, SAGE Publications, Vol. 4 ( 2012-01), p. 518468-
    Abstract: Fault severity estimation is an important part of a condition-based maintenance system, which can monitor the performance of an operation machine and enhance its level of safety. In this paper, a novel method based on statistical property and residual signals is developed for estimating the fault severity of rotating machinery. The fast Fourier transformation (FFT) is applied to extract the so-called multifrequency-band energy (MFBE) from the vibration signals of rotating machinery with different fault severity levels in the first stage. Usually these features of the working conditions with different fault sensitivities are different. Therefore a sensitive features-selecting algorithm is defined to construct the feature matrix and calculate the statistic parameter (mean) in the second stage. In the last stage, the residual signals computed by the zero space vector are used to estimate the fault severity. Simulation and experimental results reveal that the proposed method based on statistics and residual signals is effective and feasible for estimating the severity of a rotating machine fault.
    Type of Medium: Online Resource
    ISSN: 1687-8140 , 1687-8140
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2012
    detail.hit.zdb_id: 2501620-9
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