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  • MDPI AG  (6)
  • Li, Wei  (6)
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  • MDPI AG  (6)
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  • 1
    Online Resource
    Online Resource
    Targeting Energy Protection as a Novel Strategy to Disclose Di’ao Xinxuekang against the Cardiotoxicity Caused by Doxorubicin
    MDPI AG ; 2023
    In:  International Journal of Molecular Sciences Vol. 24, No. 2 ( 2023-01-04), p. 897-
    Details
    In: International Journal of Molecular Sciences, MDPI AG, Vol. 24, No. 2 ( 2023-01-04), p. 897-
    Abstract: Doxorubicin (DOX) can induce myocardial energy metabolism disorder and further worsen heart failure. “Energy protection” is proposed as a new cardiac protection strategy. Previous studies have found that Di’ao Xinxuekang (DXXK) can improve doxorubicin-induced cardiotoxicity in mice by inhibiting ferroptosis. However, there are very few studies associating DXXK and energy protection. This study aims to explore the “energy protection” effect of DXXK on cardiotoxicity induced by DOX. A DOX-induced cardiotoxicity model established in rats and H9c2 cells are used to analyze the therapeutic effects of DXXK on serum indexes, cardiac function indexes and cardiac histopathology. The metabonomic methods were used to explore the potential mechanism of DXXK in treating DOX-induced cardiotoxicity. In addition, we also observed the mitochondrial- and autophagy-related indicators of myocardial cells and the mRNA expression level of the core target regulating energy-metabolism-related pathways. Our results indicated that DXXK can improve cardiac function, reduce myocardial enzymes and alleviate the histological damage of heart tissue caused by DOX. In addition, DXXK can improve mitochondrial damage induced by DOX and inhibit excessive autophagy. Metabonomics analysis showed that DOX can significantly affects the pathways related to energy metabolism of myocardial cells, which are involved in the therapeutic mechanism of DXXK. In conclusion, DXXK can treat DOX-induced cardiotoxicity through the AMPK-mediated energy protection pathway.
    Type of Medium: Online Resource
    ISSN: 1422-0067
    URL: Article
    DOI: 10.3390/ijms24020897
    Language: English
    Publisher: MDPI AG
    Publication Date: 2023
    detail.hit.zdb_id: 2019364-6
    SSG: 12
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    Online Resource
  • 2
    Online Resource
    Online Resource
    Impact of Human Activities on Hydrological Drought Evolution in the Xilin River Basin
    MDPI AG ; 2022
    In:  Atmosphere Vol. 13, No. 12 ( 2022-12-10), p. 2079-
    Details
    In: Atmosphere, MDPI AG, Vol. 13, No. 12 ( 2022-12-10), p. 2079-
    Abstract: The impact of human activities on the hydrological cycle makes hydrological drought no longer a natural disaster in a strict sense, and influences the stationarity of the hydrologic process. In this context, assessment methods that consider nonstationary conditions are more reasonable in the study of hydrological drought. In this study, we used the SWAT (Soil and Water Assessment Tool) model to reconstruct the historical hydrological conditions during the period affected by human activities (1998–2019) of the Xilin River Basin. After calculating the standardized runoff index (SRI) at multiple time scales, we compared the drought characteristics of the basin under natural conditions and under the influence of human activities. The results show that human activities were the main reason for the significant decrease of runoff in the basin (an obvious change-point for runoff series is identified in 1998), which accounted for 68%. Compared with natural conditions, human activities delayed the occurrence of short-term drought in the basin and changed its seasonal distribution characteristics, resulting in an increase in the frequency of severe and extreme droughts in autumn; the corresponding drought frequency increased by 15% and 60%, respectively. Moreover, human activities have also prolonged drought duration, increased drought intensity, and increased the uncertainty of drought in the basin. The proposed method is demonstrated to be efficient in quantifying the effects of human activities on hydrological drought, and the findings of this study provide a scientific basis for water resource management, drought early warning, and forecasting under a changing environment.
    Type of Medium: Online Resource
    ISSN: 2073-4433
    URL: Article
    DOI: 10.3390/atmos13122079
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2605928-9
    SSG: 23
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    Online Resource
  • 3
    Online Resource
    Online Resource
    Improvement of Bacterial Blight Resistance in Two Conventionally Cultivated Rice Varieties by Editing the Noncoding Region
    MDPI AG ; 2022
    In:  Cells Vol. 11, No. 16 ( 2022-08-16), p. 2535-
    Details
    In: Cells, MDPI AG, Vol. 11, No. 16 ( 2022-08-16), p. 2535-
    Abstract: xa13 is a recessive pleiotropic gene that positively regulates rice disease resistance and negatively regulates rice fertility; thus, seriously restricting its rice breeding application. In this study, CRISPR/Cas9 gene-editing technology was used to delete the Xa13 gene promoter partial sequence, including the pathogenic bacteria-inducible expression element. Rice with the edited promoter region lost the ability for pathogen-induced gene expression without affecting background gene expression in leaves and anthers, resulting in disease resistance and normal yield. The study also screened a family of disease-resistant and normal fertile plants in which the target sequence was deleted and the exogenous transgene fragment isolated in the T1 generation (transgene-free line). Important agronomic traits of the T2 generation rice were examined. T2 generation rice with/without exogenous DNA showed no statistical differences compared to the wild type in heading stage, plant height, panicles per plant, panicle length, or seed setting rate in the field. Two important conventional rice varieties, namely Kongyu131 (KY131, Geng/japonica) and Huanghuazhan (HHZ, Xian/indica), were successfully transformed, and disease-resistant and fertile materials were obtained. Currently, these are the two important conventional rice varieties in China that can be used directly for production after improvement. Expression of the Xa13 gene in the leaves of transgenic rice (KY-PD and HHZ-PD) was not induced after pathogen infection, indicating that this method can be used universally and effectively to promote the practical application of xa13, a recessive disease-resistant pleiotropic gene, for rice bacterial blight resistance. Our study on the regulation of gene expression by editing noncoding regions of the genes provides a new idea for the development of molecular design breeding in the future.
    Type of Medium: Online Resource
    ISSN: 2073-4409
    URL: Article
    DOI: 10.3390/cells11162535
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2661518-6
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    Online Resource
  • 4
    Online Resource
    Online Resource
    Seasonal Variations of Ecosystem Water Use Efficiency and Their Responses to Climate Factors in Inner Mongolia of China
    MDPI AG ; 2022
    In:  Atmosphere Vol. 13, No. 12 ( 2022-12-11), p. 2085-
    Details
    In: Atmosphere, MDPI AG, Vol. 13, No. 12 ( 2022-12-11), p. 2085-
    Abstract: Ecosystem water use efficiency (eWUE) is a useful metric to examine the interactions between water and carbon cycles in ecosystems. To reveal the response and adaptation characteristics of different vegetation types within the context of global warming on a regional scale, the spatiotemporal characteristics and influencing factors of the seasonal eWUE of various vegetation types in Inner Mongolia from 2001 to 2020 were explored. Based on MODIS gross primary productivity (GPP), evapotranspiration (ET) data and meteorological data, in this study, we estimated eWUE in different seasons in Inner Mongolia and used trend analysis and correlation analysis methods to analyze the relationship between eWUE in spring, summer and autumn and the temperature–precipitation. From 2001 to 2020, in this region, the GPP and ET in spring, summer and autumn showed increasing trends. In addition, the growth rates of GPP and ET in spring and summer were higher than those in autumn. Under the combined effect of GPP and ET, eWUE in different seasons showed a significant decreasing trend (p 〈 0.05)—this is ascribed to the extent of ET increasing more than GPP, especially in summer, with the most obvious decreasing rate. In terms of spatial trend, in spring and summer, there is a decreasing trend from northeast to southwest. The effects of precipitation and temperature on the eWUE in Inner Mongolia were mainly negatively correlated in the northeastern part of Inner Mongolia with higher altitudes during the spring and autumn seasons. In total, 95.096% of the total area had positive correlations between eWUE and temperature in spring. In summer, the region in which the WUE of the vegetation had an inverse relationship with both the temperature and the amount of precipitation was the largest compared to these regions in spring and autumn.
    Type of Medium: Online Resource
    ISSN: 2073-4433
    URL: Article
    DOI: 10.3390/atmos13122085
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2605928-9
    SSG: 23
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  • 5
    Online Resource
    Online Resource
    Temporal and Spatial Distribution Characteristics of Drought and Its Influence on Vegetation Change in Xilin Gol, China
    MDPI AG ; 2022
    In:  Atmosphere Vol. 13, No. 11 ( 2022-10-22), p. 1743-
    Details
    In: Atmosphere, MDPI AG, Vol. 13, No. 11 ( 2022-10-22), p. 1743-
    Abstract: Drought hinders economic and social growth in many areas of China, especially in livestock-dominated Xilin Gol League in Inner Mongolia. Most studies exclusively utilize rainfall to measure drought. To clarify the spatial and temporal distribution characteristics and evolution rules of meteorological drought, monthly observation data from nine meteorological stations in Xilin Gol were used to calculate the (effective drought index, EDI). We studied the spatiotemporal pattern of drought and its influence on vegetation in Xilin Gol using the Mann–Kendall test, (empirical orthogonal function, EOF) decomposition, and quantitative representation. (1) The annual average EDI declined by 0.029/10a, and Xilin Gol experienced an average of 0.5 drought occurrences every year. (2) A normal incidence in Xilin Gol is 67.17–72.65%, and that of severe drought is 0.02–0.99%. (3) Xilin Gol’s drought intensity is mostly concentrated in the central, northeast, and southwest regions, especially southwest and central. (4) The first two principal feature vectors in Xilin Gol contributed 52.75% and 14.38% to the variance. (5) The average (normalized differential vegetation index, NDVI )of desert, typical, and meadow steppe increased, especially in typical steppe (0.034/10a). (6) In Xilin Gol, the NDVI–EDI correlation coefficient ranges from −0.642 to 0.888, with an average of 0.392. Only 1.7% of the areas are adversely linked.
    Type of Medium: Online Resource
    ISSN: 2073-4433
    URL: Article
    DOI: 10.3390/atmos13111743
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2605928-9
    SSG: 23
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  • 6
    Online Resource
    Online Resource
    Improvement on the Use of Se@C in Batteries by Synergistic Effect of Nano-Confinement and C-Se Bond
    MDPI AG ; 2023
    In:  Batteries Vol. 9, No. 3 ( 2023-02-21), p. 143-
    Details
    In: Batteries, MDPI AG, Vol. 9, No. 3 ( 2023-02-21), p. 143-
    Abstract: In order to alleviate the cyclic attenuation caused by the dissolution of poly-selenides in lithium/sodium storage devices, quantitative selenium was slowly evaporated on the surface of sodium citrate derived carbon (SCDC) at low temperature, and simultaneously the element Se was doped. Benefiting from the synergistic effects of the domain-limiting effect of embedded nanopores on Se nanoparticles and the stability of SCDC with Se doped during the embedding and stripping of Na ions, Se@C versus sodium metal exhibits high second specific capacity of 485 mAh·g−1 and unexpected stability at 0.1 A g−1 and 1 A g−1. Se@C versus lithium metal exhibits high second specific capacity of 1185 mAh·g−1 at 0.1 A g−1 and excellent stability. Together with the simple and application of synthesis method, Se@C composite is expected to become an anode material for large sodium/lithium storage devices.
    Type of Medium: Online Resource
    ISSN: 2313-0105
    URL: Article
    DOI: 10.3390/batteries9030143
    Language: English
    Publisher: MDPI AG
    Publication Date: 2023
    detail.hit.zdb_id: 2813972-0
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