In:
The Journal of the Acoustical Society of America, Acoustical Society of America (ASA), Vol. 131, No. 4_Supplement ( 2012-04-01), p. 3366-3366
Abstract:
The aim of this work was to develop paclitaxel-liposome loaded microbubbles (PTX-loaded MBs) and to investigate the efficacy of chemotherapy through ultrasound-triggered drug delivery in vitro and in vivo. PTX-loaded liposomes were prepared by a minor modification of thin film hydration method and further conjugated to the surface of microbubbles through biotin-avidin linkage. The resulting payload-loaded MBs were characterized and applied to ultrasound assisted chemotherapy in breast cancer. Our results showed the MBs were able to achieve satisfactory drug encapsulation efficiency. Under ultrasound exposure, about 9.54-fold higher drug release and a significant improvement of cell uptake than that of loaded liposomes were observed. In addition, PTX-loaded MBs showed significantly greater tumor growth inhibition both in vitro and in vivo xenograft growth of breast tumor cells, compared with PTX-loaded liposomes and unloaded MBs. Drug distributions assay in various organs (heart, liver, spleen, lung, kidney and tumor) indicated about 3-fold higher PTX enriched in tumor. Histological examinations further demonstrated the tumor growth inhibition might contribute to increased apoptosis and reduced angiogenesis in tumor xenografts. In conclusion, the study indicated the PTX-loaded MBs significantly increased the anti-tumor efficacy and can be used as a potential chemotherapy approach for ultrasound assisted breast cancer treatment.
Type of Medium:
Online Resource
ISSN:
0001-4966
,
1520-8524
Language:
English
Publisher:
Acoustical Society of America (ASA)
Publication Date:
2012
detail.hit.zdb_id:
1461063-2
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