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  • Hindawi Limited  (2)
  • Li, Lanjuan  (2)
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  • Hindawi Limited  (2)
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  • 1
    Online Resource
    Online Resource
    Effects of Different Therapeutic Schedules on Patients with COVID-19: A Prospective Case–Control Study in China
    Hindawi Limited ; 2022
    In:  Advanced Gut & Microbiome Research Vol. 2022 ( 2022-6-21), p. 1-10
    Details
    In: Advanced Gut & Microbiome Research, Hindawi Limited, Vol. 2022 ( 2022-6-21), p. 1-10
    Abstract: Background and Aims. At present, a targeted drug has not been found for patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This study assessed the effects of different therapeutic schedules on patients with COVID-19. Methods. The clinical characteristics, the prognosis of patients with western medicine (WM) treatment, and the combination of traditional Chinese medicine and western medicine (TCM-WM) treatment were retrospectively explored from January 20, 2020 to February 20, 2021. Results. 19 patients (15.20%) and 7 patients (5.60%) in the WM treatment group developed into severe type and critically ill, which were higher than 5 patients (9.43%) and 0 patients (0.00%) in the TCM-WM treatment group ( p = 0.306 and p = 0.08 ). The time from admission to severe in the WM treatment group was significantly shorter than that of the TCM-WM treatment group (7.5 vs. 11.2, p 〈 0.001 ). Compared with patients in the TCM-WM treatment group, the average stay time and the negative nucleic acid time of patients in the WM treatment group were both significantly longer (both p 〈 0.05 ). Besides, there existed no statistical difference for the safety of the two treatment options and nucleic acid test positive 14 days after discharge between the two groups. In line with the performance for severe patients, the average stay, the nucleic acid negative time, and the days of hormone therapy in the WM treatment group were all significantly longer than that of the TCM-WM treatment group (32.5 vs. 18.8, p 〈 0.001 ; 24.5 vs. 14.5, p 〈 0.001 ; 6.5 vs. 3.0, p 〈 0.001 ). Conclusions. TCM-WM has better performance in both the disease progression and treatment of severe patients. We recommended that timely TCM-WM should be treated with patients with COVID-19.
    Type of Medium: Online Resource
    ISSN: 2755-1652
    URL: Article
    DOI: 10.1155/2022/7009876
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 3147471-8
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    Online Resource
  • 2
    Online Resource
    Online Resource
    Th1/Th2 Cells and Associated Cytokines in Acute Hepatitis E and Related Acute Liver Failure
    Hindawi Limited ; 2020
    In:  Journal of Immunology Research Vol. 2020 ( 2020-11-17), p. 1-8
    Details
    In: Journal of Immunology Research, Hindawi Limited, Vol. 2020 ( 2020-11-17), p. 1-8
    Abstract: Background and Aims. The involvement of cellular immunity in the development of hepatitis E virus (HEV) infection is rare. We aimed to study the roles of viral load and Th cell responses in acute hepatitis E (AHE) and HEV-related acute liver failure (HEV-ALF). Methods. We evaluated viral load and Th1/Th2 cytokine levels in 34 patients with HEV infection, including 17 each with AHE or HEV-ALF. Seventeen healthy controls (HCs) were also included who were negative for anti-HEV IgM and IgG. Results. There was no significant difference in viral load and HEV RNA in the AHE and HEV-ALF groups (both P 〉 0.05 ). The Th lymphocyte levels (CD3+, CD4+) in the AHE and HEV-ALF groups were significantly higher than those in the HC group (both P 〈 0.05 ), but there was no significant difference between the AHE and HEV-ALF groups ( P 〉 0.05 ). Both IFN-γ and IL-10 showed gradual upward trend from the HC group to the AHE (both P 〈 0.01 ), but IFN-γ showed a sharp downward trend from the AHE group to the HEV-ALF group ( P 〈 0.01 ) and IL-4 showed gradual upward trend from the AHE group to the HEV-ALF group ( P 〈 0.01 ).There was no significant difference in Th1 and Th2 cytokines between the HEV RNA(+) group and HEV RNA(-) group (all P 〉 0.05 ). Th2 bias was observed from the AHE ( ratio = 58.65 ) to HEV-ALF ( ratio = 1.20 ) groups. The level of IFN-γ was associated with the outcome of HEV-ALF patients. Conclusions. HEV viral load was not associated with aggravation of AHE, and the HEV-ALF patients showed significant Th2 bias, which may be involved in the aggravation of AHE.
    Type of Medium: Online Resource
    ISSN: 2314-7156 , 2314-8861
    URL: Article
    DOI: 10.1155/2020/6027361
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2020
    detail.hit.zdb_id: 2817541-4
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