In:
Frontiers in Endocrinology, Frontiers Media SA, Vol. 15 ( 2024-5-10)
Abstract:
The relationship between hormonal fluctuations in the reproductive system and the occurrence of low back pain (LBP) has been widely observed. However, the causal impact of specific variables that may be indicative of hormonal and reproductive factors, such as age at menopause (ANM), age at menarche (AAM), length of menstrual cycle (LMC), age at first birth (AFB), age at last live birth (ALB) and age first had sexual intercourse (AFS) on low back pain remains unclear. Methods This study employed Bidirectional Mendelian randomization (MR) using publicly available summary statistics from Genome Wide Association Studies (GWAS) and FinnGen Consortium to investigate the causal links between hormonal and reproductive factors on LBP. Various MR methodologies, including inverse-variance weighted (IVW), MR-Egger regression, and weighted median, were utilized. Sensitivity analysis was conducted to ensure the robustness and validity of the findings. Subsequently, Multivariate Mendelian randomization (MVMR) was employed to assess the direct causal impact of reproductive and hormone factors on the risk of LBP. Results After implementing the Bonferroni correction and conducting rigorous quality control, the results from MR indicated a noteworthy association between a decreased risk of LBP and AAM (OR=0.784, 95% CI: 0.689-0.891; p=3.53E-04), AFB (OR=0.558, 95% CI: 0.436-0.715; p=8.97E-06), ALB (OR=0.396, 95% CI: 0.226-0.692; p=0.002), and AFS (OR=0.602, 95% CI: 0.518-0.700; p=3.47E-10). Moreover, in the reverse MR analysis, we observed no significant causal effects of LBP on ANM, AAM, LMC and AFS. MVMR analysis demonstrated the continued significance of the causal effect of AFB on LBP after adjusting for BMI. Conclusion Our study explored the causal relationship between ANM, AAM, LMC, AFB, AFS, ALB and the prevalence of LBP. We found that early menarche, early age at first birth, early age at last live birth and early age first had sexual intercourse may decrease the risk of LBP. These insights enhance our understanding of LBP risk factors, offering valuable guidance for screening, prevention, and treatment strategies for at-risk women.
Type of Medium:
Online Resource
ISSN:
1664-2392
DOI:
10.3389/fendo.2024.1326761
DOI:
10.3389/fendo.2024.1326761.s001
DOI:
10.3389/fendo.2024.1326761.s002
DOI:
10.3389/fendo.2024.1326761.s003
DOI:
10.3389/fendo.2024.1326761.s004
DOI:
10.3389/fendo.2024.1326761.s005
DOI:
10.3389/fendo.2024.1326761.s006
DOI:
10.3389/fendo.2024.1326761.s007
DOI:
10.3389/fendo.2024.1326761.s008
DOI:
10.3389/fendo.2024.1326761.s009
DOI:
10.3389/fendo.2024.1326761.s010
DOI:
10.3389/fendo.2024.1326761.s011
DOI:
10.3389/fendo.2024.1326761.s012
DOI:
10.3389/fendo.2024.1326761.s013
DOI:
10.3389/fendo.2024.1326761.s014
DOI:
10.3389/fendo.2024.1326761.s015
DOI:
10.3389/fendo.2024.1326761.s016
DOI:
10.3389/fendo.2024.1326761.s017
DOI:
10.3389/fendo.2024.1326761.s018
DOI:
10.3389/fendo.2024.1326761.s019
Language:
Unknown
Publisher:
Frontiers Media SA
Publication Date:
2024
detail.hit.zdb_id:
2592084-4
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