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  • Wiley  (10)
  • Li, Jun  (10)
  • 1
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    Association of Parenteral Anticoagulation Therapy With Outcomes in Non–ST‐Segment Elevation Acute Coronary Syndrome Patients Without Invasive Therapy: Findings from the Improving Care for Cardiovascular Disease in China (CCC) project
    Wiley ; 2021
    In:  Clinical Pharmacology & Therapeutics Vol. 110, No. 4 ( 2021-10), p. 1119-1126
    Details
    In: Clinical Pharmacology & Therapeutics, Wiley, Vol. 110, No. 4 ( 2021-10), p. 1119-1126
    Abstract: Our previous study showed that parenteral anticoagulation therapy (PACT) in the context of aggressive antiplatelet therapy failed to improve clinical outcomes in patients undergoing percutaneous coronary intervention for non–ST‐segment elevation acute coronary syndrome (NSTE‐ACS). However, the role of PACT in patients managed medically remains unknown. This observational cohort study enrolled patients with NSTE‐ACS receiving medical therapy from November 2014 to June 2017 in the Improving Care for Cardiovascular Disease in China‐Acute Coronary Syndrome project. Eligible patients were included in the PACT group and non‐PACT group. The primary outcomes were in‐hospital all‐cause mortality and major bleeding. The secondary outcome included minor bleeding. Among 23,726 patients, 8,845 eligible patients who received medical therapy were enrolled. After adjusting the potential confounders, PACT was not associated with a lower risk of in‐hospital all‐cause mortality (adjusted odds ratio (OR), 1.25; 95% confidence interval (CI), 0.92–1.71; P  = 0.151). Additionally, PACT did not increase the incidence of major bleeding or minor bleeding (major bleeding: adjusted OR, 1.04; 95% CI, 0.80–1.35; P  = 0.763; minor bleeding: adjusted OR, 1.27; 95% CI, 0.91–1.75; P  = 0.156). The propensity score analysis confirmed the primary analyses. In patients with NSTE‐ACS receiving antiplatelet therapy, PACT was not associated with a lower risk of in‐hospital all‐cause mortality or a higher bleeding risk in patients with NSTE‐ACS receiving non‐invasive therapies and concurrent antiplatelet strategies. Randomized clinical trials are warranted to reevaluate the safety and efficacy of PACT in all patients with NSTE‐ACS who receive noninvasive therapies and current antithrombotic strategies.
    Type of Medium: Online Resource
    ISSN: 0009-9236 , 1532-6535
    URL: Issue
    URL: Article
    DOI: 10.1002/cpt.v110.4
    DOI: 10.1002/cpt.2370
    RVK:
    XA 36900
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2040184-X
    SSG: 15,3
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  • 2
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    A combined radiomic model distinguishing GISTs from leiomyomas and schwannomas in the stomach based on endoscopic ultrasonography images
    Wiley ; 2023
    In:  Journal of Applied Clinical Medical Physics Vol. 24, No. 7 ( 2023-07)
    Details
    In: Journal of Applied Clinical Medical Physics, Wiley, Vol. 24, No. 7 ( 2023-07)
    Abstract: Endoscopic ultrasonography (EUS) is recommended as the best tool for evaluating gastric subepithelial lesions (SELs); nonetheless, it has difficulty distinguishing gastrointestinal stromal tumors (GISTs) from leiomyomas and schwannomas. GISTs have malignant potential, whereas leiomyomas and schwannomas are considered benign. Purpose This study aimed to establish a combined radiomic model based on EUS images for distinguishing GISTs from leiomyomas and schwannomas in the stomach. Methods EUS images of pathologically confirmed GISTs, leiomyomas, and schwannomas were collected from five centers. Gastric SELs were divided into training and testing datasets based on random split‐sample method (7:3). Radiomic features were extracted from the tumor and muscularis propria regions. Principal component analysis, least absolute shrinkage, and selection operator were used for feature selection. Support vector machine was used to construct radiomic models. Two radiomic models were built: the conventional radiomic model included tumor features alone, whereas the combined radiomic model incorporated features from the tumor and muscularis propria regions. Results A total of 3933 EUS images from 485 cases were included. For the differential diagnosis of GISTs from leiomyomas and schwannomas, the accuracy, sensitivity, specificity, and area under the receiver operating characteristic curve were 74.5%, 72.2%, 78.7%, and 0.754, respectively, for the EUS experts; 76.8%, 74.4%, 81.0%, and 0.830, respectively, for the conventional radiomic model; and 90.9%, 91.0%, 90.6%, and 0.953, respectively, for the combined radiomic model. For gastric SELs  〈 20 mm, the accuracy, sensitivity, specificity, and area under the receiver operating characteristic curve of the combined radiomic model were 91.4%, 91.6%, 91.1%, and 0.960, respectively. Conclusions We developed and validated a combined radiomic model to distinguish gastric GISTs from leiomyomas and schwannomas. The combined radiomic model showed better diagnostic performance than the conventional radiomic model and could assist EUS experts in non‐invasively diagnosing gastric SELs, particularly gastric SELs  〈 20 mm.
    Type of Medium: Online Resource
    ISSN: 1526-9914 , 1526-9914
    URL: Issue
    URL: Article
    DOI: 10.1002/acm2.v24.7
    DOI: 10.1002/acm2.14023
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2010347-5
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  • 3
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    A time course study about gene expression of post‐thermal injury with DNA microarray
    Wiley ; 2015
    In:  International Journal of Dermatology Vol. 54, No. 7 ( 2015-07), p. 757-764
    Details
    In: International Journal of Dermatology, Wiley, Vol. 54, No. 7 ( 2015-07), p. 757-764
    Abstract: Burn injury is one of the most common and devastating forms of trauma in daily life. However, the exact sequence of events after burn injury remains unknown. Objective This study aims to investigate gene expression alterations after burn injury. Methods Microarray data set GSE 8056 was downloaded from the Gene Expression Omnibus ( GEO ) database, including 12 samples, equally distributed in four groups: normal skin tissue as control and damaged tissues 1–3 days after burn (early period); 4–7 days after burn (middle period); and more than 7 days after burn (late period). Packages in R language were utilized to pre‐process the data and filter out the differentially expressed genes ( DEG s). Functional annotation of all three groups of DEG s was conducted by using clusters of orthologous groups analysis. The DEG s shared by all three groups were picked out and analyzed with STRING to set up a protein–protein interaction network. CF inder was chosen to implement module analysis, and expression analysis systematic explorer was then adopted to reveal the dysfunctional pathways for each module. Results A total of 727, 782, and 445 DEG s were identified in the early, middle, and late period after burn, and 234 DEG s were identified as continually differentially expressed throughout all time periods, including genes encoding proinflammatory cytokines, such as interleukin ( IL )‐6, IL ‐8, and IL ‐1 β , and genes associated with cell proliferation. Three modules associated with cell proliferation and inflammatory responses were generated from the protein–protein interaction network. Conclusion Our findings are beneficial for understanding the progression of the wound healing response after burn.
    Type of Medium: Online Resource
    ISSN: 0011-9059 , 1365-4632
    URL: Issue
    URL: Article
    DOI: 10.1111/ijd.2015.54.issue-7
    DOI: 10.1111/ijd.12534
    Language: English
    Publisher: Wiley
    Publication Date: 2015
    detail.hit.zdb_id: 2020365-2
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  • 4
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    Micro RNA ‐98 regulates osteogenic differentiation of human bone mesenchymal stromal cells by targeting BMP 2
    Wiley ; 2017
    In:  Journal of Cellular and Molecular Medicine Vol. 21, No. 2 ( 2017-02), p. 254-264
    Details
    In: Journal of Cellular and Molecular Medicine, Wiley, Vol. 21, No. 2 ( 2017-02), p. 254-264
    Abstract: To study the effects of micro RNA ‐98 (miR‐98) on human bone mesenchymal stromal cells ( hBMSC s). The patients undergoing hip arthroplasty were selected by inclusion/exclusion criteria for this study. The extracted hBMSC s were detected of osteogenic differentiation by alizarin red S staining, and of cell phenotype by flow cytometry. Bioinformatics, dual luciferase report, western blotting, RT ‐ PCR and immunoblotting were used in our study. The hBMSC s were divided into miR‐98 mimics, miR‐98 negative control ( NC ), miR‐98 inhibitors, Mock and miR‐98 inhibitors + si BMP 2 groups. Human bone mesenchymal stromal cells were extracted and purified in vitro and had specific cytological morphology, surface markers and abilities of self‐renewal and differentiation. Compared with the NC group and Mock group, the miR‐98 mimics group showed increased miR‐98 level while the miR‐98 inhibitors group decreased miR‐98 level (both P 〈 0.01). Dual luciferase reporter showed BMP 2 was the target gene of miR‐98. The levels of mRNA and protein expression of BMP 2, protein expression of RUNX 2, alkaline phosphatase activity and osteocalcin content significantly decreased in the miR‐98 mimics group while increased in the miR‐98 inhibitors group and showed no changes in the NC group and Mock group (all P 〈 0.05). The miR‐98 mimics group showed obviously declined stained red particles and the miR‐98 inhibitors group showed opposite result. After lowering the expression of miR‐98, osteogenic differentiation ability of hBMSC s rose, which was weakened by the transfection with si BMP 2. miR‐98 may regulate osteogenic differentiation of hBMSC s by targeting BMP 2.
    Type of Medium: Online Resource
    ISSN: 1582-1838 , 1582-4934
    URL: Issue
    URL: Article
    DOI: 10.1111/jcmm.2017.21.issue-2
    DOI: 10.1111/jcmm.12961
    Language: English
    Publisher: Wiley
    Publication Date: 2017
    detail.hit.zdb_id: 2076114-4
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  • 5
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    Phase III trial of docetaxel cisplatin 5‐fluorouracil induction chemotherapy for resectable oral cancer suggests favorable pathological response as a surrogate endpoint for good therapeutic outcome
    Wiley ; 2021
    In:  Cancer Communications Vol. 41, No. 3 ( 2021-03), p. 279-283
    Details
    In: Cancer Communications, Wiley, Vol. 41, No. 3 ( 2021-03), p. 279-283
    Type of Medium: Online Resource
    ISSN: 2523-3548 , 2523-3548
    URL: Issue
    URL: Article
    DOI: 10.1002/cac2.v41.3
    DOI: 10.1002/cac2.12136
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2922913-3
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  • 6
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    Involvement of Notch signaling in early chick ovarian follicle development
    Wiley ; 2016
    In:  Cell Biology International Vol. 40, No. 1 ( 2016-01), p. 65-73
    Details
    In: Cell Biology International, Wiley, Vol. 40, No. 1 ( 2016-01), p. 65-73
    Abstract: The formation of primordial follicles is a crucial process in the establishment of follicle pools required for the female's reproductive life span. For laying hens, ample follicles are a prerequisite for high laying performance. Notch signaling plays critical roles in germ cell cysts breakdown and in the formation of primordial follicles. Here, we investigated the role of Notch signaling in the ovarian development of post‐hatch chicks. Results showed that around post‐hatch day 4 (H4), the germ cell cysts broke apart, oocytes became surrounded by squamous pregranulosa cells, and the primordial follicles were then formed. Subsequently, we detected the expression of Notch signaling‐related genes including Notch receptors ( Notch1 , 2 ), ligands ( Jag1 , 2 and Dll1 , 4 ), and target genes ( Hes1 , Hey1 ). These genes all showed expression at H4 and some of these genes were up‐regulated during primordial follicle formation. To evaluate the Notch signaling requirement for early follicular development, we adopted an in vitro ovary culture system. Suppression of Notch signaling by γ‐secretase inhibitor induced a decrease of primordial follicles and an increase of germ cells in cysts. Attenuating Notch signaling also inhibited the phosphatidylinositol 3‐kinase/protein kinase B pathways and suppressed cadherin expression. These results suggest that Notch signaling is endowed with an indispensable role in primordial follicle formation in post‐hatch chicks.
    Type of Medium: Online Resource
    ISSN: 1065-6995 , 1095-8355
    URL: Issue
    URL: Article
    DOI: 10.1002/cbin.v40.1
    DOI: 10.1002/cbin.10538
    Language: English
    Publisher: Wiley
    Publication Date: 2016
    detail.hit.zdb_id: 1462519-2
    SSG: 12
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  • 7
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    High‐Mobility Two‐Dimensional Electron Gas at InGaN/InN Heterointerface Grown by Molecular Beam Epitaxy
    Wiley ; 2018
    In:  Advanced Science Vol. 5, No. 9 ( 2018-09)
    Details
    In: Advanced Science, Wiley, Vol. 5, No. 9 ( 2018-09)
    Abstract: Due to the intrinsic spontaneous and piezoelectric polarization effect, III‐nitride semiconductor heterostructures are promising candidates for generating 2D electron gas (2DEG) system. Among III‐nitrides, InN is predicted to be the best conductive‐channel material because its electrons have the smallest effective mass and it exhibits large band offsets at the heterointerface of GaN/InN or AlN/InN. Until now, that prediction has remained theoretical, due to a giant gap between the optimal growth windows of InN and GaN, and the difficult epitaxial growth of InN in general. The experimental realization of 2DEG at an InGaN/InN heterointerface grown by molecular beam epitaxy is reported here. The directly probed electron mobility and the sheet electron density of the InGaN/InN heterostructure are determined by Hall‐effect measurements at room temperature to be 2.29 × 10 3 cm 2 V −1 s −1 and 2.14 × 10 13 cm −2 , respectively, including contribution from the InN bottom layer. The Shubnikov–de Haas results at 3 K confirm that the 2DEG has an electron density of 3.30 × 10 12 cm −2 and a quantum mobility of 1.48 × 10 3 cm 2 V −1 s −1 . The experimental observations of 2DEG at the InGaN/InN heterointerface have paved the way for fabricating higher‐speed transistors based on an InN channel.
    Type of Medium: Online Resource
    ISSN: 2198-3844 , 2198-3844
    URL: Issue
    URL: Article
    DOI: 10.1002/advs.v5.9
    DOI: 10.1002/advs.201800844
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 2808093-2
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  • 8
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    Poly(L-lysine)-Induced Aggregation of Single-Strand Oligo-DNA-Modified Gold Nanoparticles
    Wiley ; 2009
    In:  Chemistry - A European Journal Vol. 15, No. 47 ( 2009-12-07), p. 13135-13140
    Details
    In: Chemistry - A European Journal, Wiley, Vol. 15, No. 47 ( 2009-12-07), p. 13135-13140
    Type of Medium: Online Resource
    ISSN: 0947-6539 , 1521-3765
    URL: Issue
    URL: Article
    DOI: 10.1002/chem.v15:47
    DOI: 10.1002/chem.200900916
    RVK:
    VA 1120 ; VA 3507
    Language: English
    Publisher: Wiley
    Publication Date: 2009
    detail.hit.zdb_id: 1478547-X
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  • 9
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    Co‐expression gene modules involved in cisplatin‐induced peripheral neuropathy according to sensitivity, status, and severity
    Wiley ; 2020
    In:  Journal of the Peripheral Nervous System Vol. 25, No. 4 ( 2020-12), p. 366-376
    Details
    In: Journal of the Peripheral Nervous System, Wiley, Vol. 25, No. 4 ( 2020-12), p. 366-376
    Abstract: Chemotherapy‐induced peripheral neuropathy (CIPN) is among the most disabling and frustrating problems for cancer survivors. The neurotoxicity caused by cisplatin varies greatly among patients, and few predictors of appearance, duration of symptoms, susceptibility, or severity are available. A deeper understanding of the mechanisms underlying individual differences in status, severity, or sensitivity in response to cisplatin treatment is therefore required. By analyzing the GSE64174 gene expression profile and constructing a weighted gene co‐expression network analysis (WGCNA) network, we screened gene modules and hub genes related to CIPN status, severity and sensitivity. We first identified the transcriptome profile of mouse dorsal root ganglion (DRG) samples and transformed their genes to human DRG counterparts. We then constructed WGCNA gene modules via optimal soft‐threshold power‐identification and module‐preservation analysis. Comprehensive analysis and identification of module hub genes were performed via functional‐enrichment analysis and significant common hub genes were identified, including “Cytoscape_cytoHubba,” “Cytoscape_MCODE,” and “Metascape_MCODE.” Brown, green, and blue modules were selected to represent CIPN sensitivity, status, and severity, respectively, via trait‐module correlational analysis. Additionally, functional enrichment analysis results indicated that these three modules were associated with some crucial biological functions, such as neutrophil migration, chemokine‐mediated signaling pathway, and PI3K‐Akt signaling pathway. We then identified seven common hub genes via three methods, including CXCL10, CCL21, CCR2, CXCR4, TLR4, NPY1R, and GALR2, related to CIPN status, severity and sensitivity. Our results provide possible targets and mechanism insights into the development and progress of CIPN, which can guide further transformation and pre‐clinical research.
    Type of Medium: Online Resource
    ISSN: 1085-9489 , 1529-8027
    URL: Issue
    URL: Article
    DOI: 10.1111/jns.v25.4
    DOI: 10.1111/jns.12407
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2030613-1
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  • 10
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    Integrating Chinese and western medicine for COVID‐19: A living evidence‐based guideline (version 1)
    Wiley ; 2021
    In:  Journal of Evidence-Based Medicine Vol. 14, No. 4 ( 2021-12), p. 313-332
    Details
    In: Journal of Evidence-Based Medicine, Wiley, Vol. 14, No. 4 ( 2021-12), p. 313-332
    Abstract: The coronavirus disease 2019 (COVID‐19) has turned into a pandemic and resulted in huge death tolls and burdens. Integrating Chinese and western medicine has played an important role in the fight against the COVID‐19 pandemic. Purpose We aimed to develop a living evidence‐based guideline of integrating Chinese and western medicine for COVID‐19. Study design Living evidence‐based guideline. Methods This living guideline was developed using internationally recognized and accepted guideline standards, dynamically monitoring the release of new clinical evidence, and quickly updating the linked living systematic review, evidence summary tables, and recommendations. Modified Delphi method was used to reach consensus for all recommendations. The certainty of the evidence, resources, and other factors were fully considered, and the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) approach was used to rate the certainty of evidence and the strength of recommendations. Results The first version of this living guidance focuses on patients who are mild or moderate COVID‐19. A multidisciplinary guideline development panel was established. Ten clinical questions were identified based on the status of evidence and a face‐to‐face experts’ consensus. Finally, nine recommendations were reached consensus, and were formulated from systematic reviews of the benefits and harms, certainty of evidence, public accessibility, policy supports, feedback on proposed recommendations from multidisciplinary experts, and consensus meetings. Conclusion This guideline panel made nine recommendations, which covered five traditional Chinese medicine (TCM) prescription granules/decoction (MXXFJD, QFPD, XFBD, TJQW, and JWDY), three Chinese patent medicines (LHQW granules/capsule, JHQG granules, and LHQK granules), and one Chinese herbal injection (XBJ injection). Of them, two were strongly recommended (LHQW granules/capsule and QFPD decoction), and five were weakly recommended (MXXFJD decoction, XFBD decoction, JHQG granules, TJQW granules, and JWDY decoction) for the treatment of mild and moderate COVID‐19; two were weakly recommended against (XBJ injection and LHQK granules) the treatment of mild and moderate COVID‐19. The users of this living guideline are most likely to be clinicians, patients, governments, ministries, and health administrators.
    Type of Medium: Online Resource
    ISSN: 1756-5383 , 1756-5391
    URL: Issue
    URL: Article
    DOI: 10.1111/jebm.v14.4
    DOI: 10.1111/jebm.12444
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2474496-7
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