In:
International Journal of Cancer, Wiley, Vol. 142, No. 10 ( 2018-05-15), p. 2040-2055
Abstract:
What's new? Depth of tumor invasion in the bladder wall is closely associated with metastasis in bladder cancer. The factors driving invasion and metastasis in the bladder, however, are not fully known. Here, both X‐linked inhibitor of apoptosis protein (XIAP) and RhoGDIβ, a modulator of small GTPase activity, were found to be overexpressed in high‐grade invasive human bladder cancer specimens. Moreover, in cells, XIAP positively regulated RhoGDIβ expression and invasion, while in mice with bladder cancer, RhoGDIβ expression served a critical role in lung metastasis. Further study of these novel players could help improve preventative and therapeutic strategies for bladder cancer.
Type of Medium:
Online Resource
ISSN:
0020-7136
,
1097-0215
Language:
English
Publisher:
Wiley
Publication Date:
2018
detail.hit.zdb_id:
218257-9
detail.hit.zdb_id:
1474822-8
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