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  • Li, Jing  (2)
  • 2010-2014  (2)
  • 1
    In: Journal of Cellular Biochemistry, Wiley, Vol. 113, No. 7 ( 2012-07), p. 2268-2278
    Abstract: Early diagnosis and treatment is known to improve prognosis for nasopharyngeal carcinoma (NPC). The study determined the specific peptide profiles by comparing the serum differences between NPC patients and healthy controls, and provided the basis for the diagnostic model and identification of specific biomarkers of NPC. Matrix‐assisted laser desorption/ionization time‐of‐flight mass spectrometry (MALDI‐TOF‐MS) can be used to detect the molecular mass of peptides. Mass spectra of peptides were generated after extracting and purification of 40 NPC samples in the training set, 21 in the single center validation set and 99 in the multicenter validation set using weak cationic‐exchanger magnetic beads. The spectra were analyzed statistically using FlexAnalysis™ and ClinProt™ bioinformatics software. The four most significant peaks were selected out to train a genetic algorithm model to diagnose NPC. The diagnostic sensitivity and specificity were 100% and 100% in the training set, 90.5% and 88.9% in the single center validation set, 91.9% and 83.3% in the multicenter validation set, and the false positive rate (FPR) and false negative rate (FNR) were obviously lower in the NPC group (FPR, 16.7%; FNR, 8.1%) than in the other cancer group (FPR, 39%; FNR, 61%), respectively. So, the diagnostic model including four peptides can be suitable for NPC but not for other cancers. FGA peptide fragments identified may serve as tumor‐associated biomarkers for NPC. J. Cell. Biochem. 113: 2268–2278, 2012. © 2012 Wiley Periodicals, Inc.
    Type of Medium: Online Resource
    ISSN: 0730-2312 , 1097-4644
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2012
    detail.hit.zdb_id: 1479976-5
    SSG: 12
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  • 2
    Online Resource
    Online Resource
    Trans Tech Publications, Ltd. ; 2014
    In:  Key Engineering Materials Vol. 620 ( 2014-8), p. 556-562
    In: Key Engineering Materials, Trans Tech Publications, Ltd., Vol. 620 ( 2014-8), p. 556-562
    Abstract: The virtual reality technology has been widely applied in virtual manufacturing; virtual environment which integrated with visual, auditory and tactile can be established. In this paper, a single - channel immersion machine assembly simulation system was built by EON Studio of virtual reality software and virtual peripherals. For building immersion virtual environment, three dimensional entity model of machine was established by the CATIA software, rendering and coloring it through the 3ds Max, inputting interface of EON convert file. Researching on interactive virtual assembly technology of machine was done, two interactive methods were developed through the keyboard ,mouse and other input devices or data glove ,(Flock and Bird) and other virtual peripherals respectively: one was to realize the interaction based on keyboard by the triggering sensor node, event driven and routing mechanism ; another was established the virtual hand, achieving the spatial position of manpower through driving virtual hand by data glove and (Flock and Bird) , and converted it into the position of virtual hand in virtual space, to complete the grasping, moving, releasing the object operation in immersion virtual environment, so that completing the virtual machine assembly, assembly trajectory visualization was realized, the basis was provided for the path of assembly analysis. The human-computer interface of assembly simulation system of machine develop, each module integration was realized by the transmission of information between EON Studio and machine, and reasonable guidelines for machine assembly training was provided.
    Type of Medium: Online Resource
    ISSN: 1662-9795
    URL: Issue
    Language: Unknown
    Publisher: Trans Tech Publications, Ltd.
    Publication Date: 2014
    detail.hit.zdb_id: 2073306-9
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