In:
International Journal of Cancer, Wiley, Vol. 143, No. 10 ( 2018-11-15), p. 2488-2498
Abstract:
What's new? Laterally spreading tumors, sometimes called “carpet lesions,” can grow to very large sizes on the surface of the colon without penetrating to the interior of the intestinal wall. Despite their size, LSTs rarely progress into cancer. Here, the authors compared methylation between LSTs and adenomas, which are more likely to become cancerous, as well as colorectal cancer cells and normal cells. They found that each type had its own distinct pattern of methylation, but the methylation changes clustered in the same few pathways, including the PI3K‐Akt pathway, which appear to be significant for the progression to malignant disease.
Type of Medium:
Online Resource
ISSN:
0020-7136
,
1097-0215
Language:
English
Publisher:
Wiley
Publication Date:
2018
detail.hit.zdb_id:
218257-9
detail.hit.zdb_id:
1474822-8
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