In:
BioMed Research International, Hindawi Limited, Vol. 2017 ( 2017), p. 1-14
Abstract:
The serotonin receptor gene (5-HT2A) has been reported to be a susceptible factor in behavioral and psychological symptoms of dementia (BPSD) in Alzheimer’s disease (AD). However, previous results were conflicting. We aim to investigate the association of 5-HT2A T102C with BPSD in AD using a meta-analysis. Studies were collected using PubMed, Web of Science, the Cochrane Library databases, Chinese National Knowledge Infrastructure (CNKI), and Embase. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess associations. Nine studies with 1899 AD patients with/without BPSD were included in this meta-analysis. The 102C and CC genotypes were associated with psychosis in AD (102C: p 〈 0.00001 , OR [95% CI] = 3.19 [2.12–4.79] ; CC: p 〈 0.00001 , OR [95% CI] = 7.24 [3.60–14.59] ). The TT genotype was significantly associated with hallucinations, aberrant motor behavior, and psychosis in AD (hallucinations: p = 0.001 , OR [95% CI] = 0.52 [0.36–0.77] ; aberrant motor behavior: p = 0.03 , OR [95% CI] = 0.58 [0.35–0.95] ; and psychosis: p = 0.002 , OR [95% CI] = 0.34 [0.17–0.67] ). No association was observed between T102C alleles or genotypes and delusions, agitation/aggression, depression, and apathy ( p 〉 0.05 ). Thus, the 5HT2A T102C might be a susceptible factor for hallucinations, aberrant motor behavior, and psychosis in AD. The potential mechanism of this polymorphism in BPSD in AD requires further exploration.
Type of Medium:
Online Resource
ISSN:
2314-6133
,
2314-6141
DOI:
10.1155/2017/5320135
Language:
English
Publisher:
Hindawi Limited
Publication Date:
2017
detail.hit.zdb_id:
2698540-8
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