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  • 1
    Online Resource
    Online Resource
    Experimental investigation of phase equilibria in the Nb–Si–Ta ternary system
    Walter de Gruyter GmbH ; 2016
    In:  International Journal of Materials Research Vol. 107, No. 12 ( 2016-12-08), p. 1112-1120
    Details
    In: International Journal of Materials Research, Walter de Gruyter GmbH, Vol. 107, No. 12 ( 2016-12-08), p. 1112-1120
    Abstract: The phase equilibria in the Nb–Si–Ta ternary system at 1 373 K, 1 473 K and 1 573 K were investigated by means of back-scattered electron imaging, electron probe microanalysis and X-ray diffraction. The isothermal sections at 1 373 K, 1 473 K and 1 573 K consist of two three-phase regions and seven two-phase regions, without any ternary compounds. The compounds of NbSi 2 and TaSi 2 , αNb 5 Si 3 and αTa 5 Si 3 form continuous solid solutions, respectively. The solubilities of Nb in Ta 3 Si and Ta 2 Si phases are extremely large, whereas the solubility of Si in the β(Nb, Ta) phase is relatively small.
    Type of Medium: Online Resource
    ISSN: 2195-8556 , 1862-5282
    URL: Article
    DOI: 10.3139/146.111442
    RVK:
    ZG 1100
    Language: English
    Publisher: Walter de Gruyter GmbH
    Publication Date: 2016
    detail.hit.zdb_id: 2232675-3
    detail.hit.zdb_id: 2128058-7
    detail.hit.zdb_id: 203021-4
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  • 2
    Online Resource
    Online Resource
    Therapeutic Effect and Mechanisms of the Novel Monosulfactam 0073
    American Society for Microbiology ; 2020
    In:  Antimicrobial Agents and Chemotherapy Vol. 64, No. 10 ( 2020-09-21)
    Details
    In: Antimicrobial Agents and Chemotherapy, American Society for Microbiology, Vol. 64, No. 10 ( 2020-09-21)
    Abstract: This study aimed to evaluate the antimicrobial activity of the novel monosulfactam 0073 against multidrug-resistant Gram-negative bacteria in vitro and in vivo and to characterize the mechanisms underlying 0073 activity. The in vitro activities of 0073, aztreonam, and the combination with avibactam were assessed by MIC and time-kill assays. The safety of 0073 was evaluated using 3-(4,5-dimethylthizol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and acute toxicity assays. Murine thigh infection and pneumonia models were employed to define in vivo efficacy. A penicillin-binding protein (PBP) competition assay and confocal microscopy were conducted. The inhibitory action of 0073 against β-lactamases was evaluated by the half-maximal inhibitory concentration (IC 50 ), and resistance development was evaluated via serial passage. The monosulfactam 0073 showed promising antimicrobial activity against Enterobacteriaceae , Pseudomonas aeruginosa , and Acinetobacter baumannii isolates producing metallo-β-lactamases (MBLs) and serine β-lactamases. In preliminary experiments, compound 0073 exhibited safety both in vitro and in vivo . In the murine thigh infection model and the pneumonia models in which infection was induced by P. aeruginosa and Klebsiella pneumoniae , 0073 significantly reduced the bacterial burden. Compound 0073 targeted several PBPs and exerted inhibitory effects against some serine β-lactamases. Finally, 0073 showed a reduced propensity for resistance selection compared with that of aztreonam. The novel monosulfactam 0073 exhibited increased activity against β-lactamase-producing Gram-negative organisms compared with the activity of aztreonam and showed good safety profiles both in vitro and in vivo . The underlying mechanisms may be attributed to the affinity of 0073 for several PBPs and its inhibitory activity against some serine β-lactamases. These data indicate that 0073 represents a potential treatment for infections caused by β-lactamase-producing multidrug-resistant bacteria.
    Type of Medium: Online Resource
    ISSN: 0066-4804 , 1098-6596
    URL: Article
    DOI: 10.1128/AAC.00529-20
    RVK:
    XA 24552
    Language: English
    Publisher: American Society for Microbiology
    Publication Date: 2020
    detail.hit.zdb_id: 1496156-8
    SSG: 12
    SSG: 15,3
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  • 3
    Online Resource
    Online Resource
    Experimental Determination of Phase Equilibria in the Sn-Zn-Sb System
    Springer Science and Business Media LLC ; 2015
    In:  Journal of Phase Equilibria and Diffusion Vol. 36, No. 4 ( 2015-8), p. 350-356
    Details
    In: Journal of Phase Equilibria and Diffusion, Springer Science and Business Media LLC, Vol. 36, No. 4 ( 2015-8), p. 350-356
    Type of Medium: Online Resource
    ISSN: 1547-7037 , 1863-7345
    URL: Article
    DOI: 10.1007/s11669-015-0387-1
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2015
    detail.hit.zdb_id: 2552809-9
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