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  • Hindawi Limited  (3)
  • Li, Hui  (3)
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  • Hindawi Limited  (3)
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  • 1
    Online Resource
    Online Resource
    Dexmedetomidine Alleviates Lipopolysaccharide-Induced Acute Kidney Injury by Inhibiting p75NTR-Mediated Oxidative Stress and Apoptosis
    Hindawi Limited ; 2020
    In:  Oxidative Medicine and Cellular Longevity Vol. 2020 ( 2020-10-31), p. 1-13
    Details
    In: Oxidative Medicine and Cellular Longevity, Hindawi Limited, Vol. 2020 ( 2020-10-31), p. 1-13
    Abstract: Oxidative stress and apoptosis play a key role in the pathogenesis of sepsis-associated acute kidney injury (AKI). Dexmedetomidine (DEX) may present renal protective effects in sepsis. Therefore, we studied antioxidant effects and the mechanism of DEX in an inflammatory proximal tubular epithelial cell model and lipopolysaccharide- (LPS-) induced AKI in mice. Methods. We assessed renal function (creatinine, urea nitrogen), histopathology, oxidative stress (malondialdehyde (MDA) and superoxide dismutase (SOD)), and apoptosis (TUNEL staining and Cleaved caspase-3) in mice. In vitro experiments including Cleaved caspase-3 and p75NTR/p38MAPK/JNK signaling pathways were evaluated using western blot. Reactive oxidative species (ROS) production and apoptosis were determined using flow cytometry. Results. DEX significantly improved renal function and kidney injury and also revert the substantially increased level of MDA concentrations as well as the reduction of the SOD enzyme activity found in LPS-induced AKI mice. In parallel, DEX treatment also reduced the apoptosis and Cleaved caspase-3 expression evoked by LPS. The expression of p75NTR was increased in kidney tissues of mice with AKI but decreased after treatment with DEX. In cultured human renal tubular epithelial cell line (HK-2 cells), DEX inhibited LPS-induced apoptosis and generation of ROS, but this was reversed by overexpression of p75NTR. Furthermore, pretreatment with DEX significantly downregulated phosphorylation of JNK and p38MAPK in LPS-stimulated HK-2 cells, and this effect was abolished by overexpression of p75NTR. Conclusion. DEX ameliorated AKI in mice with sepsis by partially reducing oxidative stress and apoptosis through regulation of p75NTR/p38MAPK/JNK signaling pathways.
    Type of Medium: Online Resource
    ISSN: 1942-0994 , 1942-0900
    URL: Article
    DOI: 10.1155/2020/5454210
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2020
    detail.hit.zdb_id: 2455981-7
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  • 2
    Online Resource
    Online Resource
    Upregulated Expression of Indoleamine 2, 3-Dioxygenase in Primary Breast Cancer Correlates with Increase of Infiltrated Regulatory T Cells In Situ and Lymph Node Metastasis
    Hindawi Limited ; 2011
    In:  Clinical and Developmental Immunology Vol. 2011 ( 2011), p. 1-10
    Details
    In: Clinical and Developmental Immunology, Hindawi Limited, Vol. 2011 ( 2011), p. 1-10
    Abstract: IDO has been reported to induce immunotolerance and promote metastasis in solid malignancy, but the mechanisms involved were not fully understood. In this study, the expression of IDO in primary breast cancer was examined and the correlation between the expression levels of IDO and the densities of Foxp3 + Tregs in situ was studied. The IDO stably-expressing CHO cells(IDO/CHO) were generated to evaluate the induction of Foxp3 + Tregs after coculturing with CD3 + T cells in vitro . The IDO expression in cancer was higher than that in benign diseases both at RNA and protein levels. The IDO expression was significantly upregulated in tumors of more advanced stages and with more extensive lymph node metastasis, and displayed positive linear correlation with the density of Foxp3 + Tregs. We further demonstrated that CD4 + CD25 + CD127 − Tregs could be amplified by coculturing CD3 + T cells with IDO/CHO cells in vitro which displayed increasing Foxp3 expression both at mRNA and protein levels. Our results implied that up-regulation of IDO in primary breast cancer may inhibit local immune surveillance and promote metastasis by favoring development and infiltration of Foxp3 + Tregs in the tumor microenvironment.
    Type of Medium: Online Resource
    ISSN: 1740-2522 , 1740-2530
    URL: Article
    DOI: 10.1155/2011/469135
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2011
    detail.hit.zdb_id: 2817541-4
    detail.hit.zdb_id: 2119272-8
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  • 3
    Online Resource
    Online Resource
    Thermally Responsive Composite Hydrogel via Self-Assembly for Smart Window Applications
    Hindawi Limited ; 2016
    In:  Journal of Nanomaterials Vol. 2016 ( 2016), p. 1-9
    Details
    In: Journal of Nanomaterials, Hindawi Limited, Vol. 2016 ( 2016), p. 1-9
    Abstract: A novel thermally responsive hydrogel (TRH) has been demonstrated by confining poly(ethylene oxide), poly(propylene oxide), and poly(ethylene oxide) triblock-copolymer (EPE) molecules into the pores of polymer framework. Aqueous EPE copolymer molecule had a tendency to aggregate to form clusters gradually and precipitated from water when the temperature is above a cloudy point. By adding EPE molecules into the acrylamide (AM) monomer solution, the mixture can be fabricated as uniform and transparent hydrogel via controlled radical polymerization. The polyacrylamide hydrogel is produced with a switchable optical property when subjecting to temperature variation. Such reversible thermally responsive material can be utilized as a functional material for smart window application. Additionally, the thermal responsive hydrogel is an inexpensive material, which is readily applicable as smart windows with significant reduction in material cost.
    Type of Medium: Online Resource
    ISSN: 1687-4110 , 1687-4129
    URL: Article
    DOI: 10.1155/2016/9307913
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2016
    detail.hit.zdb_id: 2229480-6
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