In:
Natural Product Communications, SAGE Publications, Vol. 7, No. 10 ( 2012-10), p. 1934578X1200701-
Abstract:
Two novel sorbicillinoid analogues, (4' Z)-sorbicillin (1) and (2 S)-2,3-dihydro-7-hydroxy-6-methyl-2-[( E)-prop-1-enyl]-chroman-4-one (2), together with three known compounds, (2 S)-2,3-dihydro-7-hydroxy-6,8-dimethyl-2-[( E)-prop-1-enyl] -chroman-4-one (3), sorbicillin (4), and 2',3'-dihydrosorbicillin (5), were isolated from the culture broth of the fungus Trichoderma sp. associated with the seastar Acanthaster planci. Their structures were determined by analysis of the NMR and MS data. Compound 1 was the first example with a Z-configuration of the C-4'/C-5’ double bond in the sorbyl side chain. Compounds 2 and 3 were uncommon monomeric sorbicillinoids with a cyclic sorbyl chain. 2, 3 and 5 showed moderate cytotoxic activities against various cancer cell lines.
Type of Medium:
Online Resource
ISSN:
1934-578X
,
1555-9475
DOI:
10.1177/1934578X1200701022
Language:
English
Publisher:
SAGE Publications
Publication Date:
2012
detail.hit.zdb_id:
2430442-6
SSG:
15,3
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