In:
Frontiers in Cell and Developmental Biology, Frontiers Media SA, Vol. 10 ( 2022-2-14)
Abstract:
Background: Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest malignant tumors worldwide and has poor prognosis. DEAD box proteins31 (DDX31) participate in cellular processes involving RNA secondary structure changes. However, the functions of DDX31 in PDAC remain to be elucidated. Methods: The key gene DDX31 was identified using a combination of a risk model and weighted gene co-expression network analysis (WGCNA) with R software. The biological functions of DDX31 in PDAC were investigated through bioinformatics analysis and in vitro experiments. Results: Combining with WGCNA and risk model, DDX31 was identified as a potential factor of the invasive metastasis properties of PDAC, and its expression was closely related to the malignant differentiation of PDAC. The results of gene set enrichment analysis (GSEA) showed that DDX31 was correlated with cell invasive metastasis and proliferation by activating MAPK signaling pathway. The inhibition of DDX31 inhibited the invasion and migration of PDAC cells. Survival analysis showed that DDX31 expression was negatively associated with the poor prognosis in patients with PDAC. Interpretation: DDX31 may be a potential factor for PDAC. The inhibition of DDX31 may be a potential way to treat PDAC.
Type of Medium:
Online Resource
ISSN:
2296-634X
DOI:
10.3389/fcell.2022.762372
DOI:
10.3389/fcell.2022.762372.s001
DOI:
10.3389/fcell.2022.762372.s002
DOI:
10.3389/fcell.2022.762372.s003
DOI:
10.3389/fcell.2022.762372.s004
DOI:
10.3389/fcell.2022.762372.s005
DOI:
10.3389/fcell.2022.762372.s006
DOI:
10.3389/fcell.2022.762372.s007
DOI:
10.3389/fcell.2022.762372.s008
DOI:
10.3389/fcell.2022.762372.s009
DOI:
10.3389/fcell.2022.762372.s010
DOI:
10.3389/fcell.2022.762372.s011
DOI:
10.3389/fcell.2022.762372.s012
DOI:
10.3389/fcell.2022.762372.s013
DOI:
10.3389/fcell.2022.762372.s014
DOI:
10.3389/fcell.2022.762372.s015
DOI:
10.3389/fcell.2022.762372.s016
DOI:
10.3389/fcell.2022.762372.s017
DOI:
10.3389/fcell.2022.762372.s018
DOI:
10.3389/fcell.2022.762372.s019
DOI:
10.3389/fcell.2022.762372.s020
Language:
Unknown
Publisher:
Frontiers Media SA
Publication Date:
2022
detail.hit.zdb_id:
2737824-X
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