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  • Wiley  (6)
  • Li, Cheng  (6)
  • 1
    In: Orthopaedic Surgery, Wiley, Vol. 14, No. 2 ( 2022-02), p. 451-455
    Abstract: Traumatic posterior atlantoaxial dislocation (PAAD) without fracture of the odontoid process is a rare injury. Closed reduction by skull traction under C‐arm fluoroscopic guidance and open reduction have been reported previously for the treatment of PAAD. Objective To report a rare case of PAAD without fracture treated by closed manual reduction and posterior fixation. To provide a new method—atlantoaxial dynamic test—for confirming the integrity of the transverse ligament after reduction and evaluate the ideal treatment strategy for traumatic PAAD without fracture of the odontoid process or rupture of the transverse ligament. Method A 54‐year‐old woman was riding in the passenger seat when her vehicle was rear‐ended by a car. X‐ray and computed tomography (CT) scans were used to diagnose PAAD without a related fracture. Closed manual reduction under C‐arm fluoroscopy was performed after applying general anesthesia via sober intubation, and the integrity of the transverse ligament was confirmed by the atlantoaxial dynamic test with C‐arm fluoroscopy. Then, pedicle screw internal fixation via the posterior approach was applied to maintain atlantoaxial stability. Results The procedure was performed uneventfully, and the patient was able to move out of bed on the first day after surgery with Philadelphia cervical gear. During a 2‐year follow‐up period, imaging data demonstrated no instability of the atlantoaxial complex. Conclusion Closed manual reduction under C‐arm fluoroscopy is an easy and effective method for PAAD. The integrity of the transverse ligament can be confirmed by C‐arm fluoroscopy through the atlantoaxial dynamic test after reduction. Pedicle screw internal fixation via the posterior approach can provide sufficient stability.
    Type of Medium: Online Resource
    ISSN: 1757-7853 , 1757-7861
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2483883-4
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  • 2
    In: Orthopaedic Surgery, Wiley, Vol. 14, No. 9 ( 2022-09), p. 2369-2379
    Abstract: Thoracic myelopathy caused by severe anterior ossification is often progressive and fails to respond to conservative treatment. Removal of the compressing ossification is the most effective method but is hard to operate. In this study, we describe a novel one‐stage posterior circumferential decompressive procedure assisted by an angled ultrasonic bone curette (UBC) for thoracic myelopathy caused by severe anterior ossification and evaluate its safety and efficacy. Methods The current study enrolled 15 consecutive patients (five men and 10 women) with thoracic myelopathy caused by severely anterior ossification between January 2017 and December 2019. All patients underwent posterior circumferential decompression assisted by angled UBC and segmental instrumentation with interbody fusion. At the time of surgery, the average age was 58.6 ± 6.3 years (47–70 years). Before and after surgery, the patient data, clinical manifestation, operative levels, blood loss, operative time, perioperative complications, Japanese Orthopaedic Association (JOA) score were recorded and analyzed retrospectively. Results All patients had successful one‐stage posterior circumferential decompression to remove anterior ossifications directly. There were 12 cases of OPLL, two cases of a calcified giant herniated disc, and one case of osteophyte. The average operation time was 153.4 ± 53.4 min (77–242 min), with a mean blood loss of 463.5 ± 155.8 mL (240–780 mL). The average length of stay in the hospital was 14.3 ± 4.7 days (9–25 days) and the mean follow‐up duration was 20.8 ± 8.8 months (12–39 months). Almost all patients had subjective improvement in motor power and gait. The average preoperative JOA score was 4.5 ± 1.6, which improved to 9.0 ± 1.8 at the final follow‐up. Postoperative differences in the overall JOA scores showed significant improvement (F = 105.446, p   〈  0.01). The overall recovery rate at the final examination scored 70.9% ± 25.0%. According to Hirabayashi's classification, eight cases were rated as excellent, four as good, two as fair, and one as unchanged. No patient was graded as deteriorated. Two patients (13.3%) experienced intraoperative cerebrospinal fluid leakage, while two cases (13.3%) experienced unilateral intercostal neuralgia, and only one (6.7%) encountered acute neurological deterioration. All these patients were treated conservatively and their neurological function improved significantly. At the follow‐up, there was no evidence of neurological deterioration. Conclusion Circumferential decompression assisted by angled UBC can preserve more posterior elements of the involved levels, maintaining an intact pleura and reducing the operation time and blood loss for thoracic myelopathy caused by severe anterior ossification. It is a safe, effective, and technically feasible method to provide surgeons with a new option for thoracic spinal circumferential decompression.
    Type of Medium: Online Resource
    ISSN: 1757-7853 , 1757-7861
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2483883-4
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  • 3
    In: Orthopaedic Surgery, Wiley, Vol. 14, No. 9 ( 2022-09), p. 2361-2368
    Abstract: To report the outcomes and feasibility of a new technique to change K‐line (−) to K‐line (+) via only a posterior approach to treat multilevel non‐continuous cervical ossification of the posterior longitudinal ligament (C‐OPLL) with kyphotic deformity. Methods In this study, 17 consecutive cases of patients who underwent vertical pressure procedure (VP) combined with posterior cervical single‐open‐door laminoplasty and instrumented fusion from January 1, 2017 to December 31, 2019 were enrolled. The following radiographic parameters: C2‐C7 Cobb angle, local Cobb angle, extent of OPLL, and the distance from OPLL to the K‐line(DK) were measured and analyzed. Clinically, the JOA score, VAS‐N and VAS‐A, NDI, and complications were collected from medical records to evaluate the clinical outcomes. Results All 17 cases shifted from K‐line (−) to K‐line (+).Comparing the preoperative images to the final follow‐up images, the mean C2‐7 Cobb angle changed from −6.94° ± 8.30° to 8.18° ± 4.43°, and the local Cobb angle altered from −9.12° ± 8.68° to 6.65° ± 6.11°. The mean DK increased from −2.64 ± 1.52 mm to 3.09 ± 2.19 mm. One patient showed C5 palsy and recovered within 3 months. The mean JOA score increased from 8.88 ± 2.11 to 14.71 ± 1.36. The average NDI decreased from 20.65 ± 7.80 to 8.94 ± 4.93. The mean VAS‐N and VAS‐A decreased from 3.44 ± 1.80 and 4.69 ± 1.97 to 1.25 ± 0.86 and 1.38 ± 1.16. All patients were followed up for at least 1 year. Conclusion A new technique added to posterior decompression and fusion (PDF), the vertical pressure procedure effectively corrects K‐line (−) to K‐line (+) and avoids the shortcomings of conventional anterior decompression and fusion (ADF) as well as PDF to provide a relatively safe and adequate decompression, cervical realignment. It pronounced satisfactory clinical outcome for extensive non‐continuous OPLL with kyphotic deformity even though OPLL remains ventral to the spinal cord.
    Type of Medium: Online Resource
    ISSN: 1757-7853 , 1757-7861
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2483883-4
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  • 4
    In: Advanced Functional Materials, Wiley, Vol. 28, No. 36 ( 2018-09)
    Abstract: High‐security nanoplatform with enhanced therapy compliance is extremely promising for tumor. Herein, using a simple and high‐efficient self‐assembly method, a novel active‐targeting nanocluster probe, namely, Ag 2 S/chlorin e6 (Ce6)/DOX@DSPE‐mPEG 2000 ‐folate (ACD‐FA) is synthesized. Experiments indicate that ACD‐FA is capable of specifically labeling tumor and guiding targeting ablation of the tumor via precise positioning from fluorescence and photoacoustic imaging. Importantly, the probe is endowed with a photodynamic “on‐off” effect, that is, Ag 2 S could effectively quench the fluorescence of chlorin e6 (89.5%) and inhibit release of 1 O 2 (92.7%), which is conducive to avoid unwanted phototoxicity during transhipment in the body, and only after nanocluster endocytosed by tumor cells could release Ce6 to produce 1 O 2 . Moreover, ACD‐FA also achieves excellent acid‐responsive drug release, and exhibits eminent chemo‐photothermal and photodynamic effects upon laser irradiation. Compared with single or two treatment combining modalities, ACD‐FA could provide the best cancer therapeutic effect with a relatively low dose, because it made the most of combined effect from chemo‐photothermal and controlled photodynamic therapy, and significantly improves the drug compliance. Besides, the active‐targeting nanocluster notably reduces nonspecific toxicity of both doxorubicin and chlorin e6. Together, this study demonstrates the potency of a newly designed nanocluster for nonradioactive concomitant therapy with precise tumor‐targeting capability.
    Type of Medium: Online Resource
    ISSN: 1616-301X , 1616-3028
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 2029061-5
    detail.hit.zdb_id: 2039420-2
    SSG: 11
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  • 5
    In: Chemistry – A European Journal, Wiley, Vol. 25, No. 31 ( 2019-06-04), p. 7553-7560
    Abstract: Given their superior penetration depths, photosensitizers with longer absorption wavelengths present broader application prospects in photodynamic therapy (PDT). Herein, Ag 2 S quantum dots were discovered, for the first time, to be capable of killing tumor cells through the photodynamic route by near‐infrared light irradiation, which means relatively less excitation of the probe compared with traditional photosensitizers absorbing short wavelengths. On modification with polydopamine (PDA), PDA‐Ag 2 S was obtained, which showed outstanding capacity for inducing reactive oxygen species (increased by 1.69 times). With the addition of PDA, Ag 2 S had more opportunities to react with surrounding O 2 , which was demonstrated by typical triplet electron spin resonance (ESR) analysis. Furthermore, the PDT effects of Ag 2 S and PDA‐Ag 2 S achieved at longer wavelengths were almost identical to the effects produced at 660 nm, which was proved by studies in vitro. PDA‐Ag 2 S showed distinctly better therapeutic effects than Ag 2 S in experiments in vivo, which further validated the enhanced regulatory effect of PDA. Altogether, a new photosensitizer with longer absorption wavelength was developed by using the hitherto‐unexplored photodynamic function of Ag 2 S quantum dots, which extended and enhanced the regulatory effect originating from PDA.
    Type of Medium: Online Resource
    ISSN: 0947-6539 , 1521-3765
    URL: Issue
    RVK:
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 1478547-X
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  • 6
    Online Resource
    Online Resource
    Wiley ; 2015
    In:  Wireless Communications and Mobile Computing Vol. 15, No. 16 ( 2015-11), p. 2038-2048
    In: Wireless Communications and Mobile Computing, Wiley, Vol. 15, No. 16 ( 2015-11), p. 2038-2048
    Abstract: Wireless local area network fingerprint‐based indoor location system is a hot topic these years because it needs no extra hardware and is very easy to deploy. However, it demands a database containing the distribution of received signal strength (RSS) of the area of interest,called radio map. Conventionally, we need to grid the area densely and manually measure RSS values on intersections, which will consume a lot of time and human resources. What is worse, change of the environment may render this database totally useless. Our consideration is to measure RSS on a small amount of these intersections and use them to build a radio propagation model. Then, this model can be deployed to predict RSS values of other intersections and reconstruct the radio map. In other words, we only need to collect a very small part the radio map and utilize the radio propagation model to recover the whole one. So far, many models have been proposed, among which the one suggested by Seidel, named floor attenuation factor propagation model, achieves great balance between computational request and accuracy. But it is not compatible with environments in some scenarios. So as to compensate for this deficiency, we take into account the angles formed by signal and surfaces of obstacles, and the results show better compatibility. The proposed model has four parameters that are related to the environments, and our second contribution in this paper is to propose a method to determine them. In fact, after collecting a small part of the radio map, we can estimate these parameters with least square method. Then, these parameters can be used to predict the signal strength at any other points in the same environment, and the whole radio map is rebuilt. According to practical experiments, performance of the radio map built by the proposed model is not as good as the manually collected one, but 80% of collecting labor is saved. Copyright © 2015 John Wiley & Sons, Ltd.
    Type of Medium: Online Resource
    ISSN: 1530-8669 , 1530-8677
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2015
    detail.hit.zdb_id: 2045240-8
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