In:
PLOS Computational Biology, Public Library of Science (PLoS), Vol. 19, No. 1 ( 2023-1-30), p. e1010847-
Abstract:
Mutations in LRRK2 are the most common genetic cause of Parkinson’s disease. Despite substantial research efforts, the physiological and pathological role of this multidomain protein remains poorly defined. In this study, we used a systematic approach to construct the general protein-protein interactome around LRRK2, which was then evaluated taking into consideration the differential expression patterns and the co-expression behaviours of the LRRK2 interactors in 15 different healthy tissue types. The LRRK2 interactors exhibited distinct expression features in the brain as compared to the peripheral tissues analysed. Moreover, a high degree of similarity was found for the LRRK2 interactors in putamen , caudate and nucleus accumbens , thus defining a potential LRRK2 functional cluster within the striatum . The general LRRK2 interactome paired with the expression profiles of its members constitutes a powerful tool to generate tissue-specific LRRK2 interactomes. We exemplified the generation of the tissue-specific LRRK2 interactomes and explored the functions highlighted by the “core LRRK2 interactors” in the striatum in comparison with the cerebellum . Finally, we illustrated how the LRRK2 general interactome reported in this manuscript paired with the expression profiles can be used to trace the relationship between LRRK2 and specific interactors of interest, here focusing on the LRRK2 interactors belonging to the Rab protein family.
Type of Medium:
Online Resource
ISSN:
1553-7358
DOI:
10.1371/journal.pcbi.1010847
DOI:
10.1371/journal.pcbi.1010847.g001
DOI:
10.1371/journal.pcbi.1010847.g002
DOI:
10.1371/journal.pcbi.1010847.g003
DOI:
10.1371/journal.pcbi.1010847.g004
DOI:
10.1371/journal.pcbi.1010847.g005
DOI:
10.1371/journal.pcbi.1010847.g006
DOI:
10.1371/journal.pcbi.1010847.g007
DOI:
10.1371/journal.pcbi.1010847.t001
DOI:
10.1371/journal.pcbi.1010847.t002
DOI:
10.1371/journal.pcbi.1010847.s001
DOI:
10.1371/journal.pcbi.1010847.s002
DOI:
10.1371/journal.pcbi.1010847.s003
DOI:
10.1371/journal.pcbi.1010847.r001
DOI:
10.1371/journal.pcbi.1010847.r002
DOI:
10.1371/journal.pcbi.1010847.r003
DOI:
10.1371/journal.pcbi.1010847.r004
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2023
detail.hit.zdb_id:
2193340-6
Permalink