In:
Experimental Dermatology, Wiley, Vol. 26, No. 12 ( 2017-12), p. 1267-1270
Abstract:
Autoantibodies against the 3 desmocollin (Dsc; Dsc1‐Dsc3) isoforms have been described in different pemphigus variants. Here, we developed state‐of‐the‐art detection systems for serum anti‐Dsc1, Dsc2 and Dsc1 IgG and IgA. These assays were applied in 5 different cohorts including pemphigus vulgaris ( PV ) patients with compatible direct immunofluorescence ( IF ) microscopy but no reactivity against desmogleins 1 and 3 (n = 24) and sera from patients with autoimmune blistering diseases with positive direct IF microscopy taken at the time of diagnosis (n = 749). We found that detection of anti‐Dsc serum reactivity is not helpful in the routine diagnosis of PV , pemphigus foliaceus and paraneoplastic pemphigus but may be valuable in pemphigus vegetans.
Type of Medium:
Online Resource
ISSN:
0906-6705
,
1600-0625
DOI:
10.1111/exd.2017.26.issue-12
Language:
English
Publisher:
Wiley
Publication Date:
2017
detail.hit.zdb_id:
2026228-0
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