In:
Movement Disorders, Wiley, Vol. 37, No. 3 ( 2022-03), p. 624-629
Abstract:
Isolated rapid eye movement sleep behavior disorder (iRBD) is prodromal for α‐synucleinopathies. Objective The aim of this study was to determine whether pathological cardiac [ 123 I]meta‐iodobenzylguanidine scintigraphy ([ 123 I]MIBG) is associated with progression of [ 18 F]fluorodeoxyglucose‐positron emission tomography–based Parkinson's disease (PD)‐related brain pattern (PDRP) expression in iRBD. Methods Seventeen subjects with iRBD underwent [ 18 F]fluorodeoxyglucose‐positron emission tomography brain imaging twice ~3.6 years apart. In addition, [ 123 I]MIBG and [ 123 I] N ‐ω‐fluoropropyl‐2β‐carbomethoxy‐3β‐(4‐iodophenyl)nortropane single‐photon emission computed tomography ([ 123 I]FP‐CIT‐SPECT) at baseline were performed. Olfactory, cognitive, and motor functions were tested annually. Results Twelve of 17 subjects had pathological [ 123 I]MIBG. At baseline, 6 of 12 of these expressed the PDRP (suprathreshold PDRP z score). At follow‐up, 12 of 17 subjects had suprathreshold PDRP z scores, associated with pathological [ 123 I]MIBG in 92% and with pathological [ 123 I]FP‐CIT‐SPECT in 75%. Subjects with pathological [ 123 I]MIBG had higher PDRP z score change per year ( P = 0.027). Three subjects phenoconverted to PD; all had pathological [ 123 I]MIBG and [ 123 I]FP‐CIT‐SPECT, suprathreshold baseline PDRP z scores, and hyposmia. Conclusions Pathological [ 123 I]MIBG was associated with progressive and suprathreshold PDRP z scores at follow‐up. Abnormal [ 123 I]MIBG likely identifies iRBD as prodromal PD earlier than pathological [ 123 I]FP‐CIT‐SPECT. © 2021 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society
Type of Medium:
Online Resource
ISSN:
0885-3185
,
1531-8257
Language:
English
Publisher:
Wiley
Publication Date:
2022
detail.hit.zdb_id:
2041249-6
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