In:
Journal of Labelled Compounds and Radiopharmaceuticals, Wiley, Vol. 59, No. 13 ( 2016-11), p. 557-564
Abstract:
Hyosine butyl bromide, the active ingredient in Buscopan, is an anticholinergic and antimuscarinic drug used to treat pain and discomfort caused by abdominal cramps. A straightforward synthesis of carbon‐14– and deuterium‐labeled Buscopan was developed using scopolamine, n ‐butyl‐1‐ 14 C bromide, and n ‐butyl‐ 2 H 9 bromide, respectively. In a second carbon‐14 synthesis, the radioactive carbon was incorporated in the tropic acid moiety to follow its metabolism. Herein, we describe the detailed preparations of carbon‐14– and deuterium‐labeled Buscopan.
Type of Medium:
Online Resource
ISSN:
0362-4803
,
1099-1344
Language:
English
Publisher:
Wiley
Publication Date:
2016
detail.hit.zdb_id:
1491841-9
SSG:
15,3
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