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  • National Library of Serbia  (7)
  • Lazarevic, Ivana  (7)
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  • National Library of Serbia  (7)
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  • 1
    Online Resource
    Online Resource
    The role of single nucleotide polymorphisms of cytokine genes in viral infections
    National Library of Serbia ; 2014
    In:  Arhiv za bioloske nauke Vol. 66, No. 2 ( 2014), p. 595-600
    Details
    In: Arhiv za bioloske nauke, National Library of Serbia, Vol. 66, No. 2 ( 2014), p. 595-600
    Abstract: Gene polymorphisms result from evolutionary processes representing mutations that survive in the population with a frequency higher than 1%. The most investigated type of gene polymorphisms are single nucleotide polymorphisms (SNPs). The SNPs of IL-12B (rs 3212227) A/C among a population of kidney graft CMV-seropositive recipients have an impact on a clinical events in cytomegalovirus (CMV) disease. Constitutive -308 G/A TNF-? polymorphism (rs1800629) is related to the susceptibility of HR-HPV-associated cervical dysplasia and cancer. SNP located 3 kb upstream of the IL- 28B gene (rs12979860) seems to be the strongest host genetic predictor of sustained virologic response (SVR) in hepatitis C genotype 1 patients. It is very important to identify viral and host genetic markers that may facilitate the risk of developing viral disease or some viral-associated cancers. In addition, these markers could be useful in the choice of effective treatments and preventive strategies against virally induced infection.
    Type of Medium: Online Resource
    ISSN: 0354-4664 , 1821-4339
    URL: Article
    DOI: 10.2298/ABS1402595C
    Language: English
    Publisher: National Library of Serbia
    Publication Date: 2014
    detail.hit.zdb_id: 2380842-1
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  • 2
    Online Resource
    Online Resource
    Prevalence of JC and BK polyomavirus excretion in the urine of HIV-infected patients from Serbia
    National Library of Serbia ; 2014
    In:  Arhiv za bioloske nauke Vol. 66, No. 2 ( 2014), p. 609-614
    Details
    In: Arhiv za bioloske nauke, National Library of Serbia, Vol. 66, No. 2 ( 2014), p. 609-614
    Abstract: BK virus (BKV) and JC virus (JCV) persist as latent infection in the kidneys. Reactivation of both viruses may be linked to immunodeficiency. The aims of this study were to determine the prevalence of BKV and JCV viruria and to evaluate the relationship between immunodeficiency and viruria in a cohort of HIV-infected patients. Urine samples from 93 HIV-infected patients were collected and tested for the presence of BKV and JCV DNA by PCR. The overall prevalence of polyomavirus DNA in urine was 74.2%. BKV DNA was detected in 30.1% urine samples and JCV DNA in 23.7% samples. Both BKV and JCV DNA were detected in 20.4% samples. There was no association between BKV/JCV urinary shedding and the degree of immunosuppression measured by CD4+ cell count. However, taking into account the severity of disease resulting from reactivation of BKV and JCV, patients with HIV/polyomavirus co-infection should be kept under frequent and regular supervision.
    Type of Medium: Online Resource
    ISSN: 0354-4664 , 1821-4339
    URL: Article
    DOI: 10.2298/ABS1402609K
    Language: English
    Publisher: National Library of Serbia
    Publication Date: 2014
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  • 3
    Online Resource
    Online Resource
    Prevalence and mutational patterns of lamivudine-resistant HBV strains in chronically infected Serbian patients
    National Library of Serbia ; 2014
    In:  Arhiv za bioloske nauke Vol. 66, No. 2 ( 2014), p. 601-608
    Details
    In: Arhiv za bioloske nauke, National Library of Serbia, Vol. 66, No. 2 ( 2014), p. 601-608
    Abstract: This study aimed to determine the prevalence and mutational patterns of lamivudine-resistant hepatitis B virus (HBV) strains in chronically infected Serbian patients. The study included 154 patients on long-term lamivudine monotherapy. Resistance-associated mutations were identified by direct sequencing of the S/P gene. The genotypic resistance to lamivudine was confirmed in 54.5% of patients. Three primary resistance-associated mutations were found: rtM204V (55.9%), rtM204I (40.5%), rtA181T (3.6%) and two compensatory mutations rtV173L (17.8%) and rtL180M (67.8%). Seven mutational patterns were discovered with rtL180M+rtM204V being dominant (41.6%). The presence of resistance associated mutations was correlated to the older age of patients, the presence of clinically relevant HBsAg mutations and higher values of viral load. No correlation with HBV genotypes, subgenotypes or HBsAg subtypes was observed. High prevalence of resistance supports the use of genotypic testing in monitoring patients on lamivudine therapy and selecting those who would benefit from therapy with newly developed nucleos(t)ide analogs.
    Type of Medium: Online Resource
    ISSN: 0354-4664 , 1821-4339
    URL: Article
    DOI: 10.2298/ABS1402601L
    Language: English
    Publisher: National Library of Serbia
    Publication Date: 2014
    detail.hit.zdb_id: 2380842-1
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  • 4
    Online Resource
    Online Resource
    Complete genome sequences and phylogenetic analysis of Hepatitis B virus isolates from Serbia
    National Library of Serbia ; 2012
    In:  Arhiv za bioloske nauke Vol. 64, No. 4 ( 2012), p. 1319-1326
    Details
    In: Arhiv za bioloske nauke, National Library of Serbia, Vol. 64, No. 4 ( 2012), p. 1319-1326
    Abstract: Although the genotype and subgenotype distribution of HBV isolates from Serbia has previously been reported, data about whole genome sequences from this area are scarce. This study included plasma samples from 5 chronically infected patients. Full genome amplification of the HBV isolates was performed by nested-PCR using 7 primer pairs, and the whole genome nucleotide sequences were obtained by direct sequencing. Two complete genome sequences belonged to D2 subgenotype (ayw3 HBsAg subtype), one to D1 (ayw2) and two to A2 (adw2). All 5 Serbian isolates clustered with sequences from the expected geographic regions and had nucleotide and coded protein length in accordance to their assigned genotypes, except for one HBeAg-negative isolate displaying G1896A mutation leading to a premature stop codon in the Pre-C region. The first complete genome sequences of HBV D1, D2 and A2 subgenotypes from Serbian patients showed characteristics similar to the nucleotide sequences of HBV isolates from other European and Middle East countries.
    Type of Medium: Online Resource
    ISSN: 0354-4664 , 1821-4339
    URL: Article
    DOI: 10.2298/ABS1204319L
    Language: English
    Publisher: National Library of Serbia
    Publication Date: 2012
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  • 5
    Online Resource
    Online Resource
    The prevalence of human polyomaviruses in urine samples of immunocompetent individuals in the Serbian population
    National Library of Serbia ; 2012
    In:  Arhiv za bioloske nauke Vol. 64, No. 4 ( 2012), p. 1383-1388
    Details
    In: Arhiv za bioloske nauke, National Library of Serbia, Vol. 64, No. 4 ( 2012), p. 1383-1388
    Abstract: The BK (BKV) and JC viruses (JCV) are human polyomaviruses. After primary infection, they persist as latent infection in the kidneys. Immunosuppression leads to their reactivation, which is associated with life-threatening diseases such as polyomavirus-induced nephropathy and progressive multifocal leukoencephalopathy. However, the behavior of these viruses in immunocompetent individuals is still an open question with no right answer. The aim of this study was to determine the prevalence of BKV and JCV shedding in the urine of immunocompetent individuals from the Serbian population. Sixty-five urine samples were collected and tested for the presence of BKV and JCV DNA by PCR. JCV DNA was detected in 19/65 (29.2%) and BKV DNA in 3/65 (4.6%) of the urine samples. Forty-three (66.2%) urine samples of the immunocompetent donors were negative for both viruses. The present study provides the first results of urinary excretion of human polyomaviruses in the Serbian population.
    Type of Medium: Online Resource
    ISSN: 0354-4664 , 1821-4339
    URL: Article
    DOI: 10.2298/ABS1204383K
    Language: English
    Publisher: National Library of Serbia
    Publication Date: 2012
    detail.hit.zdb_id: 2380842-1
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  • 6
    Online Resource
    Online Resource
    The prevalence of the most important viral infections in renal transplant recipients in Serbia
    National Library of Serbia ; 2012
    In:  Arhiv za bioloske nauke Vol. 64, No. 4 ( 2012), p. 1285-1296
    Details
    In: Arhiv za bioloske nauke, National Library of Serbia, Vol. 64, No. 4 ( 2012), p. 1285-1296
    Abstract: Viruses are the main cause of opportunistic infections after kidney transplantation. The aim of this study was to determine the prevalence of cytomegalovirus (CMV), Epstein-Barr virus (EBV), B. K. virus (BKV) and John Cunningham virus (JCV) infections in renal transplant recipients (RTR). This retrospective study of 112 RTR investigated the presence of CMV, EBV and polyomaviruses DNA in plasma and/or urine by PCR. The visualization of PCR products was performed by electrophoresis on 2% agarose gel stained with ethidium bromide and photographed under a UV light. The chi-square test was used for statistical analysis. CMV DNA was detected in 14/112 (12.5%), EBV DNA in 4/49 (8.16%), BKV DNA in 10/31 (32.26%) and JCV DNA in 3/31 (9.68%) RTR. These results show that CMV infection is more often present in RTR compared to other investigated viral infections. In the light of these results, molecular testing could be useful in identifying recipients at high risk of symptomatic post-transplant viral infection.
    Type of Medium: Online Resource
    ISSN: 0354-4664 , 1821-4339
    URL: Article
    DOI: 10.2298/ABS1204285C
    Language: English
    Publisher: National Library of Serbia
    Publication Date: 2012
    detail.hit.zdb_id: 2380842-1
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  • 7
    Online Resource
    Online Resource
    Prevalence of Epstein Barr Virus in biopsy specimens of nasopharyngeal carcinoma from Serbian patients
    National Library of Serbia ; 2014
    In:  Arhiv za bioloske nauke Vol. 66, No. 2 ( 2014), p. 537-544
    Details
    In: Arhiv za bioloske nauke, National Library of Serbia, Vol. 66, No. 2 ( 2014), p. 537-544
    Abstract: The development of nasopharyngeal carcinoma (NPC) is the result of interaction between Epstein-Barr Virus (EBV) and many non-viral factors. The aims of this study were to determine the prevalence of EBV in NPC biopsies from Serbian patients and to investigate the correlation between EBV presence and demographic, anamnestic and clinical data. Ninety-three tissue blocks were included. For detection of EBV DNA, the C terminus of the LMP1 gene was amplified by nested-PCR. Twenty-eight biopsies were EBV-DNA-positive (30.1%), with a statistically significant difference in EBV DNA presence between geographical regions (p=0.02) and between the stages of tumor-node-metastasis (TNM) (p=0.02). A correlation was also found with the presence of EBV DNA and smoking (p=0.02). The correlation of EBV DNA presence, with or without smoking and the promising outcome of the disease was statistically significant (p=0.02; p=0.01). The EBV DNA findings from this study confirm the role of EBV in NPC carcinogenesis, and show the different distribution among TNM stages and correlation between the virus and outcome of disease.
    Type of Medium: Online Resource
    ISSN: 0354-4664 , 1821-4339
    URL: Article
    DOI: 10.2298/ABS1402537B
    Language: English
    Publisher: National Library of Serbia
    Publication Date: 2014
    detail.hit.zdb_id: 2380842-1
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