GLORIA

GEOMAR Library Ocean Research Information Access

X

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • Wiley  (3)
  • Laurie, Steven S.  (3)
  • 1
    Online Resource
    Online Resource
    Impaired pulmonary gas exchange efficiency, but normal pulmonary artery pressure increases, with hypoxia in men and women with a patent foramen ovale
    Wiley ; 2020
    In:  Experimental Physiology Vol. 105, No. 9 ( 2020-09), p. 1648-1659
    Details
    In: Experimental Physiology, Wiley, Vol. 105, No. 9 ( 2020-09), p. 1648-1659
    Abstract: What is the central question of this study? Do individuals with a patent foramen ovale (PFO + ) have a larger alveolar‐to‐arterial difference in ( ) than those without (PFO − ) and/or an exaggerated increase in pulmonary artery systolic pressure (PASP) in response to hypoxia? What is the main finding and its importance? PFO + had a greater while breathing air, 16% and 14% O 2 , but not 12% or 10% O 2 . PASP increased equally in hypoxia between PFO + and PFO − . These data suggest that PFO + may not have an exaggerated acute increase in PASP in response to hypoxia. Abstract Patent foramen ovale (PFO) is present in 30–40% of the population and is a potential source of right‐to‐left shunt. Accordingly, those with a PFO (PFO + ) may have a larger alveolar‐to‐arterial difference in ( ) than those without (PFO − ) in normoxia and with mild hypoxia. Likewise, PFO is associated with high‐altitude pulmonary oedema, a condition known to have an exaggerated pulmonary pressure response to hypoxia. Thus, PFO + may also have exaggerated pulmonary pressure increases in response to hypoxia. Therefore, the purposes of the present study were to systematically determine whether or not: (1) the was greater in PFO + than in PFO − in normoxia and mild to severe hypoxia and (2) the increase in pulmonary artery systolic pressure (PASP) in response to hypoxia was greater in PFO + than in PFO − . We measured arterial blood gases and PASP via ultrasound in healthy PFO + ( n  = 15) and PFO − ( n  = 15) humans breathing air and 30 min after breathing four levels of hypoxia (16%, 14%, 12%, 10% O 2 , randomized and balanced order) at rest. The was significantly greater in PFO + compared to PFO − while breathing air (2.1 ± 0.7  vs . 0.4 ± 0.3 Torr), 16% O 2 (1.8 ± 1.2  vs . 0.7 ± 0.8 Torr) and 14% O 2 (2.3 ± 1.2  vs . 0.7 ± 0.6 Torr), but not 12% or 10% O 2 . We found no effect of PFO on PASP at any level of hypoxia. We conclude that PFO influences pulmonary gas exchange efficiency with mild hypoxia, but not the acute increase in PASP in response to hypoxia.
    Type of Medium: Online Resource
    ISSN: 0958-0670 , 1469-445X
    URL: Issue
    URL: Article
    DOI: 10.1113/eph.v105.9
    DOI: 10.1113/EP088750
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 1493802-9
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 2
    Online Resource
    Online Resource
    No effect of patent foramen ovale on acute mountain sickness and pulmonary pressure in normobaric hypoxia
    Wiley ; 2022
    In:  Experimental Physiology Vol. 107, No. 2 ( 2022-02), p. 122-132
    Details
    In: Experimental Physiology, Wiley, Vol. 107, No. 2 ( 2022-02), p. 122-132
    Abstract: What is the central question to this study? Is there a relationship between a patent foramen ovale and the development of acute mountain sickness and an exaggerated increase in pulmonary pressure in response to 7–10 h of normobaric hypoxia? What is the main finding and its importance? Patent foramen ovale presence did not increase susceptibility to acute mountain sickness or result in an exaggerated increase in pulmonary artery systolic pressure with normobaric hypoxia. This suggests hypobaric hypoxia is integral to the increased susceptibility to acute mountain sickness previously reported in those with patent foramen ovale, and patent foramen ovale presence alone does not contribute to the hypoxic pulmonary pressor response. Abstract Acute mountain sickness (AMS) develops following rapid ascent to altitude, but its exact causes remain unknown. A patent foramen ovale (PFO) is a right‐to‐left intracardiac shunt present in ∼30% of the population that has been shown to increase AMS susceptibility with high altitude hypoxia. Additionally, high altitude pulmonary oedema (HAPE) is a severe type of altitude illness characterized by an exaggerated pulmonary pressure response, and there is a greater prevalence of PFO in those with a history of HAPE. However, whether hypoxia per se is causing the increased incidence of AMS in those with a PFO and whether a PFO is associated with an exaggerated increase in pulmonary pressure in those without a history of HAPE is unknown. Participants ( n  = 36) matched for biological sex (18 female) and the presence or absence of a PFO (18 PFO+) were exposed to 7–10 h of normobaric hypoxia equivalent to 4755 m. Presence and severity of AMS was determined using the Lake Louise AMS scoring system. Pulmonary artery systolic pressure, cardiac output and total pulmonary resistance were measured using ultrasound. We found no significant association of PFO with incidence or severity of AMS and no association of PFO with arterial oxygen saturation. Additionally, there was no effect of a PFO on pulmonary pressure, cardiac output or total pulmonary resistance. These data suggest that hypobaric hypoxia is necessary for those with a PFO to have increased incidence of AMS and that presence of PFO is not associated with an exaggerated pulmonary pressor response.
    Type of Medium: Online Resource
    ISSN: 0958-0670 , 1469-445X
    URL: Issue
    URL: Article
    DOI: 10.1113/eph.v107.2
    DOI: 10.1113/EP089948
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 1493802-9
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 3
    Online Resource
    Online Resource
    Lower transfer factor of the lung for carbon monoxide in women with a patent foramen ovale
    Wiley ; 2022
    In:  Experimental Physiology Vol. 107, No. 3 ( 2022-03), p. 243-252
    Details
    In: Experimental Physiology, Wiley, Vol. 107, No. 3 ( 2022-03), p. 243-252
    Abstract: What is the central question of this study? Do individuals with a patent foramen ovale (PFO + ) have a lower lung transfer factor for carbon monoxide than those without (PFO − )? What is the main finding and its importance? We found a lower rate constant for carbon monoxide uptake in PFO + compared with PFO − women, which was physiologically relevant (≥0.5 z ‐score difference), but not for PFO + versus PFO − men. This suggests that factors independent of the PFO are responsible for our findings, possibly inherent structural differences in the lung. Abstract The transfer factor of the lung for carbon monoxide (TL CO ) measure assumes that all cardiac output flows through the pulmonary circuit. However, right‐to‐left blood flow through a shunt can result in a lower transfer factor than predicted. A patent foramen ovale (PFO) is a potential source of right‐to‐left shunt that is present in ∼35% of the population, but the effect of PFO on TL CO is unknown. We sought to determine the effect of PFO on the TL CO . We conducted a retrospective analysis of TL CO data from 239 (101 women) participants. Anthropometrics and lung function, including spirometry, plethysmography and TL CO , were compiled from our previously published work. Women, but not men, with a PFO had a significantly lower TL CO and rate constant for carbon monoxide uptake ( K CO ) (percentage of predicted and z ‐score) than women without a PFO. Women and men with a PFO had normal alveolar volumes that did not differ from those without a PFO. Correcting the data for haemoglobin in a subset of subjects did not change the results ( n  = 58; 25 women). The lower K CO in women with versus without a PFO was physiologically relevant (≥0.5 z ‐score difference). There was no effect of PFO in men. This suggests that factors independent of the PFO are responsible for our findings, possibly inherent structural differences in the lung.
    Type of Medium: Online Resource
    ISSN: 0958-0670 , 1469-445X
    URL: Issue
    URL: Article
    DOI: 10.1113/eph.v107.3
    DOI: 10.1113/EP090176
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 1493802-9
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...