In:
Journal of the Renin-Angiotensin-Aldosterone System, Hindawi Limited, Vol. 18, No. 1 ( 2017-01), p. 147032031668933-
Abstract:
Angiotensin-(3−4) (Ang-(3−4) or Val-Tyr) is the shorter angiotensin (Ang) II-derived peptide, formed through successive hydrolysis that culminates with the release of Val-Tyr as a dipeptide. It is formed both in plasma and in kidney from Ang II and Ang III, and can be considered a component of the systemic and organ-based renin–angiotensin system. It is potently antihypertensive in humans and rats, and its concerted actions on proximal tubule cells culminate in the inhibition of fluid reabsorption, hyperosmotic urinary excretion of Na + . At the renal cell signaling level, Ang-(3−4) counteracts Ang II-type 1 receptor-mediated responses by acting as an allosteric enhancer in Ang II-type 2 receptor populations that target adenosine triphosphate-dependent Ca 2+ and Na + transporters through a cyclic adenosine monophosphate-activated protein kinase pathway.
Type of Medium:
Online Resource
ISSN:
1470-3203
,
1752-8976
DOI:
10.1177/1470320316689338
Language:
English
Publisher:
Hindawi Limited
Publication Date:
2017
detail.hit.zdb_id:
2261873-9
Permalink